Cord Blood News Volume 7.04 | Feb 5 2015

G-CSF as an Adjunctive Therapy with Umbilical Cord Blood Cell Transplantation for Traumatic Brain Injury
Scientists demonstrate remarkable combined efficacy of human umbilical cord blood cell therapy and granulocyte-colony stimulating factor (G-CSF) treatment in traumatic brain injury (TBI) models, providing essential evidence for the translation of this approach to treat TBI. [Cell Transplant] Full Article

Exploring the Heterogeneity of the Hematopoietic Stem and Progenitor Cell Pool in Cord Blood: Simultaneous Staining for Side Population, Aldehyde Dehydrogenase Activity, and CD34 Expression
Investigators developed a protocol for simultaneous determination of CD34⁺, side population, and aldehyde dehydrogenase⁺ populations in relation to immature white blood cells in cord blood. [Transfusion] Abstract

Cell Fusion between Gastric Epithelial Cells and Mesenchymal Stem Cells Results in Epithelial-to-Mesenchymal Transition and Malignant Transformation
Researchers investigated the effect of cell fusion between mesenchymal stem cells and the gastric epithelial cells in tumorigenesis. Cell fusion between cord blood mesenchymal stem cells and human gastric epithelial cells was performed in vitro. [BMC Cancer] Full Article

Application of Affinity Aqueous Two-Phase Systems for the Fractionation of CD133⁺ Stem Cells from Human Umbilical Cord Blood
The authors implemented traditional and novel immunoaffinity aqueous two-phase systems to prove the viability of cluster of differentiation 133 (CD133⁺) stem cells from human umbilical cord blood. [J Mol Recognit] Abstract

Wharton’s Jelly Transplantation Improves Neurologic Function in a Rat Model of Traumatic Brain Injury
Scientists tested the efficacy of Wharton’s jelly (WJ) tissue transplantation in a weight-drop model of traumatic brain injury (TBI) in rats. WJ tissue was cultured and transplanted into the injury site 24 hours after TBI. [Cell Mol Neurobiol] Abstract

Double Labeling of Human Umbilical Cord Mesenchymal Stem Cells with Gd-DTPA and PKH26 and the Influence on Biological Characteristics of hUCMSCs
Researchers aimed to determine whether double labeling of human umbilical cord mesenchymal stem cells (hUCMSCs) with gadolinium-diethylene triamine penta-acetic acid (Gd-DTPA) and PKH26 influences their biological characteristics. [Int J Exp Pathol] Abstract

Transplantation of Human Umbilical Cord-Derived Mesenchymal Stems Cells for the Treatment of Becker Muscular Dystrophy in Affected Pedigree Members
The utility of multipotent human umbilical cord-derived mesenchymal stem cells in the treatment of Becker muscular dystrophy (BMD), a genetic disease where muscle tissue fails to regenerate, was examined in members from a pedigree affected by BMD. [Int J Mol Med] Abstract

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Cord Blood Registry and China Cord Blood Corporation Enter into Strategic Collaboration
Cord Blood Registry^® and China Cord Blood Corporation China’s first and largest umbilical cord blood bank, entered into a memorandum of understanding regarding their strategic collaboration in China and the United States. [Cord Blood Registry^®] Press Release

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NEW Director – Vector Production (Sangamo BioSciences, Inc.)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Hematology and Oncology (Guangzhou Women and Children’s Medical Center)

Research Associate – Generating Mature Blood Cells from Induced Pluripotent Stem Cells (University of Cambridge)

Postdoctoral Fellow – Targeted Gene Editing in Hematopoietic Stem Cells (University Medical Center Freiburg)

Principal Investigator – Stem Cell Biology, Hematopoiesis and Hematology (Guangzhou Women and Children’s Medical Center)

PhD Studentships – Expansion of Umbilical Cord Blood Stem Cells (University College London)

Postdoctoral Position – Hematopoietic Gene Regulation and Leukemia (Boston Children’s Hospital)

Cord Tissue Processing Technician (Cord Blood Registry)

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