Immune Thrombocytopenia: Antiplatelet Autoantibodies Inhibit Proplatelet Formation by Megakaryocytes and Impair Platelet Production In Vitro Investigators examined the effects of serum and IgG from 19 immune thrombocytopenia patients using day 8 or 9 megakaryocytes, derived from cord blood hematopoietic stem cells. [Haematologica] Abstract | Full Article Transplanted Umbilical Cord Mesenchymal Stem Cells Modify the In Vivo Microenvironment Enhancing Angiogenesis and Leading to Bone Regeneration Scientists prepared clinical-grade umbilical cord (UC) mesenchymal stem cells (MSC) from Wharton’s jelly and they investigated if UC-MSC could be used as substitutes for bone marrow MSC in muscoloskeletal regeneration as a more readily available and functional source of MSCs. [Stem Cells Dev] Abstract Expression of a Surface Antigen (MA6) by Peripheral Blood CD34+ Cells Is Correlated with Improved Platelet Engraftment and May Explain Delayed Platelet Engraftment following Cord Blood Transplantation Researchers identified a subpopulation of CD34+ cells that co-express a surface antigen — “MA6”, which is more positively correlated with platelet engraftment in a clinical setting than CD34+ alone. [Stem Cells Dev] Abstract Human Placenta-Derived Adherent Cells Improve Cardiac Performance in Mice with Chronic Heart Failure PDA-001, an intravenous formulation of placenta-derived adherent cells, is in clinical development for the treatment of autoimmune and inflammatory diseases. Scientists tested the therapeutic effects of PDA-001 in mice with chronic heart failure. [Stem Cells Transl Med] Abstract | Full Article Developing a Co-Culture System for Effective Megakaryo/Thrombopoiesis from Umbilical Cord Blood Hematopoietic Stem/Progenitor Cells Investigators exploited a two-stage culture protocol to study the effect of different parameters on the megakaryo/thrombopoiesis ex vivo. In the expansion stage, human umbilical cord blood-derived CD34+-enriched cells were expanded in co-culture with human bone marrow mesenchymal stromal cells. [Cytotherapy] Abstract Bone Formation by Human Umbilical Cord Perivascular Cells Scientists investigated the possibility of employing human umbilical perivascular cells within the context of finding an alternative source of mesenchymal stromal cells for bone tissue engineering. [J Biomed Mater Res A] Abstract Comparative Quantification of the Surfaceome of Human Multipotent Mesenchymal Progenitor Cells Investigators employed subcellular fractionation with quantitative discovery proteomics to define the cell-surface interface proteome of human bone marrow mesenchymal stromal/stem cells and human umbilical cord perivascular cells. [Stem Cell Reports] Full Article |