Cord Blood News Volume 7.08 | Mar 5 2015

N-Butylidenephthalide Attenuates Alzheimer’s Disease-Like Cytopathy in Down Syndrome Induced Pluripotent Stem Cell-Derived Neurons
To recapitulate an Alzheimer’s disease cell model, Down syndrome induced pluripotent stem cells, reprogrammed from mesenchymal stem cells in amniotic fluid, were directed toward a neuronal lineage.
[Sci Rep] Full Article

Plerixafor on Demand in Ten Healthy Family Donors as a Rescue Strategy to Achieve an Adequate Graft for Stem Cell Transplantation
Researchers report ten healthy hematopoietic stem cell donors treated with plerixafor because of insufficient response to granulocyte-colony-stimulating (G-CSF) alone or contraindication to G-CSF. [Transfusion] Abstract

MicroRNA-21 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells by the PI3K/β-Catenin Pathway
MicroRNA-21 (miR-21) mimics and the antisense miR-21 were transfected to human umbilical cord mesenchymal stem cells (hUMSCs), and the capacity of miR-21 for the osteogenic differentiation of hUMSCs was evaluated by expression of osteogenic markers encoding alkaline phosphatase, runt-related gene-2 and osteocalcin, as well as by Alizarin red S staining. [J Orthop Res] Abstract

Co-Infusion of Mesenchymal Stromal Cells Has No Effect on Relapse and Infection in Leukemia Patients Undergoing Haploidentical Hematopietic Stem Cell Transplantation
Investigators observed the outcomes of mesenchymal stromal cells co-infusion during haploidentical hematopietic stem cell transplantation (haplo-HSCT) and compared the relapse and infection rates with patients receiving traditional haplo-HSCT. [Leuk Lymphoma] Abstract

Conditioned Medium from Umbilical Cord Mesenchymal Stem Cells Induces Migration and Angiogenesis
Scientists hypothesized that the paracrine effects of umbilical cord mesenchymal stem cells may enhance stem cell-based tissue repair and regeneration by promoting the specific homing of stem/progenitor cells and the overall ability to drive them to the damaged area. [Mol Med Rep] Abstract | Download Full Article

One Million Hemopoietic Stem-Cell Transplants: A Retrospective Observational Study
The authors aimed to document the activity worldwide from the beginning of transplantation and search for region adapted indications and associations between transplant rates and macroeconomics. [Lancet Haematol]
Abstract | Press Release

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UW to Test ‘Breakthrough’ Pediatric Leukemia Treatment
A promising method of immunotherapy to treat children with relapsed acute lymphocytic leukemia (ALL) is opening at the University of Wisconsin Carbone Cancer Center and American Family Children’s Hospital. The trial is open to relapsed/refractory pediatric ALL patients who have limited treatment options. [University of Wisconsin] Press Release

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Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Fellows – Leukemia Research and Stem Cell Biology (Josep Carreras Leukemia Research Institute)

PhD Studentship – Stem Cells and Tissue Engineering (Queensland University of Technology)

Postdoctoral Scientist – Hematopoietic Stem Cell Transplantation (Indiana University)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

Director – Vector Production (Sangamo BioSciences, Inc.)

PhD Studentships – Expansion of Umbilical Cord Blood Stem Cells (University College London)

Cord Tissue Processing Technician (Cord Blood Registry)

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