CD133 Allows Elaborated Discrimination and Quantification of Hematopoietic Progenitor Subsets in Human Hematopoietic Stem Cell Transplants To qualify the assessment of CD133 for routine quality control of adult hematopoietic stem cell (HSC) sources, researchers analyzed the developmental potentials of CD133+ and CD133low subpopulations in bone marrow and peripheral blood stem cells. Similar to umbilical cord blood, CD133 expression objectively discriminated functionally distinct subpopulations in adult HSC sources. [Br J Haematol] Abstract Computational Modeling of the Expansion of Human Cord Blood CD133+ Hematopoietic Stem/Progenitor Cells with Different Cytokine Combinations Scientists developed a computational model based on cellular signaling interactions that predict the influence of a cytokine on the survival, duplication and differentiation of the CD133+ hematopoietic stem and progenitor cell subset from human umbilical cord blood. [Bioinformatics] Abstract Paracrine Effects of Mesenchymal Stem Cells Induce Senescence and Differentiation of Glioblastoma Stem-Like Cells Scientists found that conditioned media from bone marrow and umbilical cord derived mesenchymal stem cells mediated cell cycle arrest of glioblastoma multiforme stem-like cells by downregulating cyclin D1. [Cell Transplant] Full Article Wnt3a Protein Reduces Growth Factor-Driven Expansion of Human Hematopoietic Stem and Progenitor Cells in Serum-Free Cultures Researchers demonstrated that exogenous Wnt3a protein suppresses rather than promotes the expansion of umbilical cord blood-derived CD34+ cells in serum free expansion cultures. [PLoS One] Full Article Hypothermia Augments Neuroprotective Activity of Mesenchymal Stem Cells for Neonatal Hypoxic-Ischemic Encephalopathy Scientists hypothesized that combined treatment with hypothermia and transplantation of human umbilical cord blood-derived mesenchymal stem cells would synergistically attenuate severe hypoxic-ischemic encephalopathy compared to stand-alone therapy. [PLoS One] Full Article Comparative Proteomic Analysis of Two Distinct Stem-Cell Populations from Human Amniotic Fluid Investigators characterized two distinct types of stem cells isolated from residual amniotic fluid material derived from prenatal diagnostic amniocentesis. [Mol Biosyst] Abstract Investigating the Effect of Hypoxic Culture on the Endothelial Differentiation of Human Amniotic Fluid-Derived Stem Cells Scientists investigated the ability of amniotic fluid-derived stem cells to differentiate down an endothelial lineage with the aim of producing an endothelial-like cell suitable for use in pre-vascularization. [J Anat] Abstract Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Germ-Like Cells in Mouse Seminiferous Tubules The authors’ previous study demonstrated that human umbilical cord mesenchymal stem cells (HUMSCs) were capable of differentiation into germ cells in vitro. To assess this potential in vivo, HUMSCs were microinjected into the lumen of seminiferous tubules of immunocompetent mice, which were treated with busulfan to destroy endogenous spermatogenesis. [Mol Med Rep] Abstract | Download Full Article |