Cord Blood News Volume 7.16 | Apr 30 2015

Comparative Study between Amniotic-Fluid Mesenchymal Stem Cells and Retinal Pigmented Epithelium (RPE) Stem Cells Ability to Differentiate towards RPE Cells
Amniotic fluid-derived mesenchymal stem cells and RPE stem cells were isolated, characterized to assay their stemness and induced to neuronal/retinal differentiation; specific RPE markers were then analyzed. [Cell Tissue Res] Abstract

Stem Cell Factor Is Essential for Preserving NOD/SCID Reconstitution Capacity of Ex Vivo Expanded Cord Blood CD34⁺ Cells
CD34⁺ cells were cultured with or without stem cell factor supplementation in serum-free medium for ten days. Expanded cells were transplanted into sublethally irradiated non-obese diabetic/severe combined immune-deficient (NOD/SCID) mice. Engraftment and multilineage reconstitution of transplanted cells were determined. [Cell Prolif] Abstract

UV-Activated 7-Dehydrocholesterol-Coated Titanium Implants Promote Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Osteoblasts
Investigators examined the impact of titanium implants surfaces coated with UV-irradiated 7-dehydrocholesterol on the osteogenic differentiation of human umbilical cord mesenchymal stem cells. [J Biomater Appl] Abstract

Induction of Insulin-Producing Cells from Umbilical Cord Blood-Derived Stromal Cells by Activation of the c-Met/HGF Axis
Researchers attempted to differentiate adult stem cells produced from umbilical cord blood-derived stromal cells into insulin-producing cells (IPCs). By activating the c-Met/HGF axis through temporal hypoxia treatment and hepatocyte growth factor supplementation, their protocol resulted in the differentiation of cells into functional pancreatic endocrine cells with increased viability. [Dev Growth Differ] Abstract

Human Mesenchymal Stem Cells Improve the Neurodegeneration of Femoral Nerve in a Diabetic Foot Ulceration Rats
Scientists explored the potential role of human mesenchymal stem cells-umbilical cord blood (hMSCs-UC) in femoral nerve neuropathy. In hMSCs-UC-treated model rats, serum NGF was increased with higher positive rate of NF-200. [Neurosci Lett] Abstract

The Role of Children’s Bone Marrow Mesenchymal Stromal Cells in the Ex Vivo Expansion of Autologous and Allogeneic Hematopoietic Stem Cells
Researchers evaluated the effects of children’s bone marrow mesenchymal stromal cells on the ex vivo expansion capacity of both allogeneic cord blood and autologous bone marrow CD34⁺ hematopoietic stem cells when used as a cell feeder layer with or without recombinant cytokines. [Cell Biol Int] Abstract

Similar Outcomes of Allogeneic Hematopoietic Cell Transplantation from Unrelated Donor and Umbilical Cord Blood vs. Sibling Donor for Pediatric Acute Myeloid Leukemia: Multicenter Experience in China
Investigators conducted a retrospective study on 73 pediatric acute myeloid leukemia patients who were primary refractory or in greater than CR1 and investigated MSD, URD, and UCB hematopoietic cell transplantation. [Pediatr Transplant] Abstract

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Genmab Announces Phase III Study of Arzerra^® Met Primary Endpoint of Improved Progression-Free Survival in Patients with Relapsed CLL
Genmab A/S announced that the top-line results from the Phase III COMPLEMENT 2 study showed that treatment with Arzerra^® (ofatumumab) plus fludarabine and cyclophosphamide met the primary endpoint of improved progression-free survival in patients with relapsed chronic lymphocytic leukemia (CLL) compared to those given fludarabine and cyclophosphamide alone. [Genmab A/S] Press Release

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Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Associate – Epigenetic Regulation of Normal and Leukemic Stem Cells (Sanford-Burnham Medical Research Institute)

Postdoctoral Fellow – Hematopoietic Stem Cell Biology (University of Leuven)

Postdoctoral Fellow – Hematopoietic Stem Cell Research (Lund University)

Postdoctoral Research Fellow – Stem Cell/Hematopoiesis Research (BloodCenter of Wisconsin)

Research Associate – Hematopoietic and Leukemic Stem Cells (Shanghai Jiao-Tong University School of Medicine)

Postdoctoral Fellows – Leukemia Research and Stem Cell Biology (Josep Carreras Leukemia Research Institute)

Cord Tissue Processing Technician (Cord Blood Registry)

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