Cord Blood News Volume 7.23 | Jun 18 2015

Treatment with Agonistic DR3 Antibody Results in Expansion of Donor Tregs and Reduced Graft-Versus-Host Disease
The authors investigated whether treating donor mice with a single dose of agonistic antibody to DR3 could alleviate acute graft versus host disease in a MHC-mismatched bone marrow transplantation model. [Blood] Abstract

Treprostinil Indirectly Regulates Endothelial Colony Forming Cell Angiogenic Properties by Increasing VEGF-A Produced by Mesenchymal Stem Cells
Researchers examined the effect of treprostinil on endothelial colony forming cells (ECFC) obtained from cord blood in terms of colony numbers, proliferative and clonogenic properties in vitro, as well as in vivo vasculogenic properties. Treprostinil inhibited viability of cultured ECFC but did not modify their clonogenic properties or the endothelial differentiation potential from cord blood stem cells. [Thromb Haemost]
Abstract | Full Article

The Impact of Repeated Autologous Infusion of Hematopoietic Stem Cells in Patients with Liver Insufficiency
Investigators assessed the clinical and biochemical effects of repeated stem cell infusion. Ninety patients with liver cirrhosis were randomized to receive either one session treatment or two sessions four months apart of autologous hematopoietic stem cells transplantation and a control group who received regular liver treatment. [Stem Cell Res Ther] Abstract | Full Article

Retinal Angiogenesis Effects of TGF-β1, and Paracrine Factors Secreted from Human Placental Stem Cells in Response to a Pathological Environment
Investigators evaluated the role of systemically injected human placental amniotic membrane-derived mesenchymal stem cells (AMSCs) on pathological neovascularization of proliferative retinopathy. They determined that AMSCs secreted higher levels of transforming growth factor beta (TGF-β1) than other mesenchymal stem cells and the secreted TGF-β1 directly suppressed the proliferation of endothelial cells under pathological conditions in vitro. [Cell Transplant] Abstract

Comparative Characterization of Cells from the Various Compartments of the Human Umbilical Cord Shows that the Wharton’s Jelly Compartment Provides the Best Source of Clinically Utilizable Mesenchymal Stem Cells
The authors compared the histology, fresh and cultured cell numbers, morphology, proliferation, viability, stemness characteristics and differentiation potential of cells from the amnion, subamnion, perivascular, Wharton’s jelly, and mixed cord of five umbilical cords. [PLoS One] Full Article

In Vivo Tracking of Human Placenta Derived Mesenchymal Stem Cells in Nude Mice via (14)C-TdR Labeling
Researchers investigated the bio-distribution of human placental deciduas basalis derived mesenchymal stem cells in nude mice after intravenous injection by carbon radioisotope labeling thymidine ((14)C-TdR). [BMC Biotechnol] Abstract

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Connecticut Innovations’ Regenerative Medicine Research Fund Awards $11 Million for Scientific Research
BioInnovation Connecticut announced that the Regenerative Medicine Research Fund has awarded $11 million to scientists who are conducting biomedical, embryonic or human adult stem cell research. [Mayo Clinic] Press Release

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Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Hematopoietic Stem Cell Biology (Harvard Medical School)

Assistant/Associate Professor – Hematologic Malignancies (MD Anderson Cancer Center)

Postdoctoral Fellow – Immune Reconstitution in Hematopoietic Stem Cell Transplantation (Stanford University)

Postdoctoral Scientist – Hematopoietic Stem Cell Transplantation (Indiana University)

Postdoctoral Position – Epigenetic Regulation of Hematopoiesis and Leukemia (Karolinska Institutet)

Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

Postdoctoral Researcher – Hematopoietic Stem Cell Physiology and Pathophysiology (International Research Center for Medical Sciences)

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