Long-Term Outcome of a Phase II Trial with Nilotinib 400 Mg Twice Daily in First-Line Treatment of Chronic Myeloid Leukemia The authors report the long-term, six-year, results of the first investigator-sponsored, GIMEMA multicenter Phase II, single-arm, trial with nilotinib 400 mg twice daily as first-line treatment in 73 chronic-phase chronic myeloid leukemia patients. [Haematologica] Abstract Impact of the Source of Hematopoietic Stem Cell in Unrelated Transplants: Comparison between 10/10, 9/10-HLA Matched Donors and Cord Blood Investigators compared the outcome of patients transplanted from unrelated cord blood with those transplanted from 9/10-HLA mismatched unrelated donors or 10/10-HLA matched related or unrelated donor. [Am J Hematol] Abstract Isolation of Foreign Material-Free Endothelial Progenitor Cells Using CD31 Aptamer and Therapeutic Application for Ischemic Injury To utilize apatmers for isolation of endothelial progenitor cells (EPCs), investigators successfully generated aptamers that recognize human CD31, an endothelial cell marker. CD31 aptamers bound to human umbilical cord blood-derived EPCs and showed specific interaction with human CD31, but not with mouse CD31. [PLoS One] Full Article Comparable Outcome after Single-Antigen-Mismatched versus Matched Unrelated Donor Haematopoietic Cell Transplantation The impact of donor matching on outcome of unrelated hematopoietic stem cell transplantation was analyzed in patients transplanted at the University of Leipzig. [J Cancer Res Clin Oncol] Abstract Umbilical Cord-Derived Mesenchymal Stem Cells Promote Proliferation and Migration in MCF-7 and MDA-MB-231 Breast Cancer Cells through Activation of the ERK Pathway Mesenchymal stem cells (MSCs) were isolated and identified from umbilical cord tissues. MDA-MB‑231 and MCF-7 cells were treated with conditioned medium from 10 and 20% umbilical cord MSCs, and the resulting changes in proliferation and migration were investigated. [Oncol Rep] Abstract Isolation of Mesenchymal Stromal/Stem Cells from Small-Volume Umbilical Cord Blood Units that Do Not Qualify for the Banking System Scientists examined the availability of freshly donated umbilical cord blood units that do not qualify for the Japanese banking system for transplantation because of their small volume as a source of mesenchymal stem cells. [Int J Hematol] Abstract Coadministration of the Human Umbilical Cord Matrix-Derived Mesenchymal Cells and Aspirin Alters Postischemic Brain Injury in Rats Scientists evaluated the protective potential of implanted human umbilical cord mesenchymal stem cells with/without aspirin against focal cerebral ischemia. [J Stroke Cerebrovasc Dis] Abstract |