Cord Blood News Volume 7.28 | Jul 23 2015

Different Procoagulant Activity of Therapeutic Mesenchymal Stromal Cells Derived from Bone Marrow and Placental Decidua
Researchers present a first safety follow-up on their clinical experience with placenta-derived decidual stromal cells, used as supportive immunomodulatory and regenerative therapy for patients with severe complications after allogeneic hematopoietic stem cell transplantation. [Stem Cells Dev] Abstract

Metabolic Syndrome in Adults Who Received Hematopoietic Stem Cell Transplantation for Acute Childhood Leukemia: An LEA Study
Researchers evaluated prospectively the incidence and risk factors of the metabolic syndrome and its components in 170 adult patients who received an hematopoietic stem cell transplantation for childhood. [Bone Marrow Transplant] Abstract

Wharton’s Jelly-Derived Mesenchymal Stem Cells Alleviate Memory Deficits and Reduce Amyloid-β Deposition in an APP/PS1 Transgenic Mouse Model
Investigators evaluated the therapeutic effect of Wharton’s Jelly-derived mesenchymal stem cells transplantation on the neuropathology and memory deficits in amyloid precursor protein and presenilin-1 double-transgenic mice. [Clin Exp Med] Abstract

Dehydrated Human Amnion/Chorion Membrane Regulates Stem Cell Activity In Vitro
PURION^® Processed dehydrated human amnion/chorion membrane allografts were evaluated for their ability to alter stem cell activity in vitro. [J Biomed Mater Res B Appl Biomater] Abstract | Press Release

Comparative Analysis of Human Mesenchymal Stem Cells from Fetal-Bone Marrow, Adipose Tissue, and Warton’s Jelly as Sources of Cell Immunomodulatory Therapy
Scientists compared human fetal bone marrow, adipose tissue, and Warton’s jelly-derived MSCs (WJ-MSCs) for surface antigen expression, differentiation ability, proliferation capacity, clonality, tolerance for aging, gene expression, and whether IFN-γ affected WJ-MSC gene expression, as determined by real time quantitative PCR. [Hum Vaccin Immunother] Abstract

Effect of Targeted Ovarian Cancer Therapy Using Amniotic Fluid Mesenchymal Stem Cells Transfected with Enhanced Green Fluorescent Protein-Human Interleukin-2 in Vivo
Investigators found that amniotic fluid mesenchymal stem cells (AF-MSCs) exhibited high motility during migration in vivo and the vector, pEGFP‑hIL‑2, can be stably transfected into AF‑MSCs. Following stable transfection, this type of stem cell was able to successfully transport the therapeutic gene, IL-2, migrate to the ovarian cancer tumor site to secrete the functional IL-2 and treat the tumor. [Mol Med Rep] Abstract

Cryopreservation of Mesenchymal Stromal Cells Derived from Various Tissues
The authors present an overview of the identification of mesenchymal stromal cells (MSCs), their tissue sources and the properties that render them suitable as a cellular therapeutic. They discuss the responses of cells during freezing and focus on the traditional and novel approaches used to cryopreserve MSCs. [Cryobiology] Abstract

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Amgen Announces Positive BLINCYTO^® (Blinatumomab) Phase II Study Results in Patients with Relapsed/Refractory Philadelphia Chromosome-Positive B-Cell Precursor Acute Lymphoblastic Leukemia
Amgen announced the top-line results of a Phase II open-label, single-arm, multicenter trial to evaluate the efficacy and safety of BLINCYTO^® in adults with relapsed or refractory Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia. [Amgen] Press Release

Medtown Ventures, LLC Announces Exclusive License Agreement with Georgia Tech Research Corporation
Medtown Ventures, LLC announced that it has entered into an exclusive license agreement with Georgia Tech Research Corporation for a new adhesive-signature based stem cell selection and isolation technology. [Medtown Ventures, LLC] Press Release

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Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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NEW Research Associate – Cell Biology (Editas Medicine)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Independent Junior Group Leader – Lymphopoiesis or Gene Regulation/Nuclear Architecture in the Hematopoietic System (Max-Planck-Institute)

Data Coordinator – Hematological Malignancies (Fred Hutchinson Cancer Research Center)

Clinical Research Coordinator – Chronic Lymphocytic Leukemia (Fred Hutchinson Cancer Research Center)

Regulatory Coordinator – Leukemia Research (Weill Cornell College of Medicine)

PhD Position – Drug Releasing, Nanostructured Biomaterials for Adult Stem Cells (Karlsruhe Institute of Technology)

Postdoctoral Fellow – Immune Reconstitution in Hematopoietic Stem Cell Transplantation (Stanford University)

Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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