Cord Blood News Volume 7.34 | Sep 3 2015

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    Cord Blood News 7.34 September 3, 2015

    Cord Blood News

         In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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    TOP STORY
    MLL Leukemia Induction by Genome Editing of Human CD34+ Hematopoietic Cells
    Scientists applied TALEN-mediated genome editing to generate endogenous mixed-lineage leukemia (MLL)-AF9 and MLL-ENL oncogenes through insertional mutagenesis in primary human hematopoietic stem and progenitor cells derived from human umbilical cord blood. [Blood] Abstract
    It all starts with the right cells! Access a range of fresh and frozen human primary cells.

     
    PUBLICATIONS (Ranked by impact factor of the journal)
    Is There a Stronger Graft-versus-Leukemia Effect Using HLA-Haploidentical Donors than with HLA-Identical Siblings?
    Scientists analyzed 10,679 acute leukemia patients who underwent HSCT from an HLA-matched sibling donor or a haploidentical donor between 2007 and 2012 [Leukemia] Abstract

    Telomere Homeostasis in Trophoblasts and in Cord Blood Cells from Pregnancies Complicated with Preeclampsia
    Researchers studied mechanisms of telomere shortening in trophoblasts from pregnancies complicated with preeclampsia (PE) and assessed telomere length and homeostasis in fetal cord blood cells from PE pregnancies. [Am J Obstet Gynecol] Abstract

    Stem Cells Isolated from Human Dental Pulp and Amniotic Fluid Improve Skeletal Muscle Histopathology in Mdx/SCID Mice
    Scientists investigated the potential of human dental pulp stem cells and human amniotic fluid stem cells to differentiate toward a skeletal myogenic lineage in order to determine the optimal conditions for achieving myogenic commitment. [Stem Cell Res Ther] Full Article

    Human Amniotic Mesenchymal Stromal Cells (hAMSCs) as Potential Vehicles for Drug Delivery in Cancer Therapy: An In Vitro Study
    Researchers investigated mesenchymal stromal cells isolated from the amniotic membrane of human term placenta as candidates for drug delivery in vitro. [Stem Cell Res Ther] Full Article

    Repeated Autologous Umbilical Cord Blood Infusions Are Feasible and Had No Acute Safety Issues in Young Babies with Congenital Hydrocephalus
    Investigators established the safety and feasibility of repeated intravenous infusions of autologous umbilical cord blood in young babies with congenital hydrocephalus. [Pediatr Res] Abstract

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    REVIEWS
    The Hematopoietic System in the Context of Regenerative Medicine
    The authors review the remarkable potential hematopoietic stem cells possess, and highlight their tremendous value as therapeutics in regenerative medicine. [Methods] Abstract

    Visit our reviews page to see a complete list of reviews in the cord blood research field.

     
    INDUSTRY NEWS
    Dallas-Fort Worth Stem Cell Researchers Use Amniotic Tissue to Successfully Treat Non-Healing Surgical Wound
    Riordan-McKenna Institute founders, stem cell expert Neil Riordan, PhD and orthopedic surgeon, Wade McKenna, DO, announced that the use of sterile, dehydrated amniotic tissue AlphaPATCHâ„¢ developed by Amniotic Therapies resulted in complete healing of an otherwise non-healing surgical knee wound. [Riordan-McKenna Institute LLC.] Press Release

    MD Anderson Cancer Center and Cellectis Announce a Broad Preclinical and Clinical Strategic Alliance in Cancer Immunotherapy
    Cellectis and The University of Texas MD Anderson Cancer Center have entered into a research and development alliance aimed at bringing novel cellular immunotherapies to patients suffering from different types of liquid tumors. [MD Anderson Cancer Center] Press Release

    NIH Awards Nearly $34 Million to UAB Center for Clinical and Translational Science
    The National Institutes of Health (NIH) has awarded the University of Alabama at Birmingham (UAB) Center for Clinical and Translational Science $33.59 million over four years to continue the center’s programs advancing translational research. [University of Alabama at Birmingham] Press Release

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    POLICY NEWS
    National Institutes of Health (United States)

    Food and Drug Administration (United States)

    Center for Biologics Evaluation and Research (United States)

    European Medicines Agency (European Union)

    Medicines and Healthcare Products Regulatory Agency (United Kingdom)

    Therapeutic Goods Administration (Australia)

     
    EVENTS
    NEW ISSCR 2016
    June 22-25, 2016
    San Francisco, United States

    Visit our events page to see a complete list of events in the cord blood community.

     
    JOB OPPORTUNITIES
    NEW Director of Research – Oncology and Hematology (CancerCare Manitoba)

    Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

    Postdoctoral Fellow – HMGA Chromatin Remodeling Proteins in Cancer and Stem Cell Biology (Johns Hopkins University School of Medicine)

    Assistant Member – Cord Blood (Fred Hutchinson Cancer Research Center)

    Laboratory Technologist – Cord Blood and Cord Tissue Bank (Texas Stem Cell)

    Postdoctoral Position – Hematopoietic Stem and Progenitor Cell Assays (Weill Cornell Medical School)

    Postdoctoral Fellow – Hematopoietic Regeneration and Myeloid Malignancies (Weill-Cornell Medical College)

    Research Associate – Cell Biology (Editas Medicine)

    Independent Junior Group Leader – Lymphopoiesis or Gene Regulation/Nuclear Architecture in the Hematopoietic System (Max-Planck-Institute)

    Postdoctoral Fellow – Immune Reconstitution in Hematopoietic Stem Cell Transplantation (Stanford University)

    Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)


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    Recruit Top Talent: Reach more than 60,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

     

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