Comparison of Outcomes of 8/8 and 7/8 Allele-Matched Unrelated BMT and Single Unit CBT in Adults with Acute Leukemia To investigate an up-to-date alternative donor selection strategy, researchers compared the transplant outcomes of 8/8 and 7/8 allele-matched unrelated bone marrow transplantation (BMT) with those of umbilical cord blood transplantation (UCBT) and redefined the role of UCBT with extended analysis. [Biol Blood Marrow Transplant] Abstract Ectopic Bone Formation by Mesenchymal Stem Cells Derived from Human Term Placenta and the Decidua Investigators provide evidence to support chorionic-derived mesenchymal stem cells (MSCs) and decidua-derived MSCs as cellular candidates with potent bone forming capacity. [PLoS One] Full Article Natural Killer Cells Improve Hematopoietic Stem Cell Engraftment by Increasing Stem Cell Clonogenicity In Vitro and in a Humanized Mouse Model The effects of accessory cells, particularly natural killer cells, on human cord blood hematopoietic stem cell functions were assessed in vitro and in vivo. [PLoS One] Full Article A Novel Bioreactor and Culture Method Drives High Yields of Platelets from Stem Cells CD34 cells isolated from umbilical cord blood were expanded with a variety of reagents and on a nanofiber membrane using serum-free medium. A novel bioreactor was developed that recapitulated aspects of the marrow vascular niche. [Transfusion] Abstract Double Umbilical Cord Blood Transplantation Is Effective Therapy for Relapsed or Refractory Hodgkin Lymphoma Researchers analyzed 27 consecutive, heavily pre-treated patients receiving double umbilical cord blood transplantation for relapsed/refractory Hodgkin lymphoma. [Leuk Lymphoma] Abstract Translating G-CSF as an Adjunct Therapy to Stem Cell Transplantation for Stroke Scientists previously demonstrated enhanced functional effects of co-treatment with granulocyte-colony stimulating factor and human umbilical cord blood cell transplantation in animal models of traumatic brain injury. Here, they suggest that the aforementioned combination therapy may also produce synergistic effects in stroke. [Transl Stroke Res] Abstract Alemtuzumab, Fludarabine, Low-Dose TBI, and Double Umbilical Cord Transplant for Primary Graft Failure in a Patient with Recurrent HLH The authors report a novel reduced intensity conditioning regimen of alemtuzumab, 4 Gy total body irradiation and fludarabine for salvage of primary graft failure followed by double umbilical cord blood transplant. [Pediatr Blood Cancer] Abstract |