Cord Blood News Volume 7.44 | Nov 12 2015

Lysophosphatidic Acid Enhances Survival of Human CD34⁺ Cells in Ischemic Conditions
Scientists showed that lysophosphatidic acid-treated human umbilical cord blood-derived CD34⁺ cells cultured under hypoxic and serum-deprived conditions present 2.2-fold and 1.3-fold higher survival relatively to non-treated cells and prostaglandin E₂-treated cells, respectively. [Sci Rep] Full Article

Mechanical Fibrinogen-Depletion Supports Heparin-Free Mesenchymal Stem Cell Propagation in Human Platelet Lysate
Investigators searched for an efficient and reproducible medium preparation method that avoids clot formation while omitting animal-derived heparin. Bone-marrow and umbilical cord derived mesenchymal stem cells were tested for surface markers by flow cytometry and for trilineage differentiation capacity. [J Transl Med] Full Article

Transplantation of Mesenchymal Stem Cells in a Laryngeal Carcinoma Patient with Radiation Myelitis
Researchers describe the outcome of allogeneic umbilical cord-derived mesenchymal stem cell transplantation in a patient with laryngeal carcinoma who developed radiation-induced myelitis of his spinal cord with characteristic magnetic resonance imaging changes. [Stem Cell Res Ther] Full Article

Evaluation of a Cell-Banking Strategy for the Production of Clinical Grade Mesenchymal Stromal Cells from Wharton’s Jelly
Factors affecting the success of the derivation process (namely, time elapsed from birth to processing and weight of fragments), and methods for establishing a two-tiered system of Master Cell Bank and Working Cell Bank of umbilical cord derived-mesenchymal stromal cells were analyzed. [Cytotherapy] Abstract

A Comparison of Wharton’s Jelly and Cord Blood as a Source of Mesenchymal Stem Cells for Diabetes Cell Therapy
Scientists investigated the differences between mesenchymal stem cells isolated from umbilical cord blood and Wharton’s jelly as sources of diabetes mellitus cell therapy. [Regen Med] Abstract

Effects of Mesenchymal Stromal Cells on Human Myeloid Dendritic Cell Differentiation and Maturation in a Humanized Mouse Model
Investigators used a humanized mouse model to study the immunomodulatory effects of human mesenchymal stromal cells on human dendritic cell immunobiology. Humanized mice were established by injection of cord blood CD34⁺ cells into NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ mice. [J Immunol Methods] Abstract

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NIH Awards City of Hope $2.2 Million Grant for Study of Chronic Graft-versus-Host Disease
The National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH) has awarded a $2.2 million grant to help City of Hope researchers explore the underlying mechanisms of graft-versus-host disease, the leading cause of long-term sickness and death following transplantation of bone marrow cells from a donor. [City of Hope (Business Wire)] Press Release

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NEW Faculty Positions – Regenerative Medicine for Organ Regeneration or Transplantation (The University of Texas Medical School at Houston)

Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Leukemia Research (City of Hope)

PhD Studentships – Cancer Research (Cancer Research UK Manchester Institute)

Faculty Member – Hematopoietic Cell Transplant (Fred Hutchinson Cancer Research Center)

Hematopoietic Stem Cell Biologist (Mayo Clinic)

Assistant or Associate Professor – Cell and Regenerative Biology (University of Wisconsin, Madison)

Assistant Member – Cord Blood Transplantation (Fred Hutchinson Cancer Research Center)

Postdoctoral Positions – Cancer and Developmental Biology (North Carolina Central University)

Research Associate – Leukemia, Stem Cells and Development (Josep Carreras Leukemia Research Institute)

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