Adipogenic Placenta-Derived Mesenchymal Stem Cells Are Not Lineage Restricted by Withdrawing Extrinsic Factors: Developing a Novel Visual Angle in Stem Cell Biology Researchers showed that after withdrawing extrinsic factors, adipogenic placental-derived mesenchymal stem cells reverted to a primitive cell population and retained stem cell characteristics. The mitochondrial network during differentiation and dedifferentiation may serve as a marker of absent or acquired pluripotency in various stem cell models. [Cell Death Dis] Full Article Role of VEGF-A in Angiogenesis Promoted by Umbilical Cord-Derived Mesenchymal Stromal/Stem Cells: In Vitro Study The authors describe pro-angiogenic properties of mesenchymal stromal/stem cells derived from human umbilical cord as manifested in vitro. [Stem Cell Res Ther] Abstract Enhanced Expression of Hepatocyte-Specific microRNAs in Valproic Acid Mediated Hepatic Trans-Differentiation of Human Umbilical Cord Derived Mesenchymal Stem Cells Investigators analyzed the expression pattern of microRNAs during hepatic trans-differentiation. The protocol employed the use of histone deacetylase inhibitor, valproic acid to induce hepatic trans-differentiation of human umbilical cord Wharton’s jelly derived mesenchymal stem cells. [Exp Cell Res] Abstract Assessment of Glial Scar, Tissue Sparing, Behavioral Recovery and Axonal Regeneration following Acute Transplantation of Genetically Modified Human Umbilical Cord Blood Cells in a Rat Model of Spinal Cord Contusion Researchers investigated the potential for protective effects of human umbilical cord blood mononuclear cells (UCB-MCs) genetically modified with the VEGF and GNDF genes on contusion spinal cord injury (SCI) in rats. They showed that a gene delivery using UCB-MCs-expressing VEGF and GNDF genes improved both structural and functional parameters after SCI. [PLoS One] Full Article Amelioration of Ischemic Brain Injury in Rats with Human Umbilical Cord Blood Stem Cells: Mechanisms of Action Scientists have tested a human umbilical cord blood-derived stem cell line that has shown both a significant reduction in stroke infarct volume as well as improved functional recovery following stroke in the rat. In the present study, they addressed the mechanism of action and compared therapeutic efficacy of high vs. low passage non-hematopoietic umbilical cord blood stem cells. [Cell Transplant] Abstract Early Human Herpes Virus Type 6 Reactivation in Umbilical Cord Blood Allogeneic Stem Cell Transplantation The authors investigated human herpes virus type 6 reactivation within 60 days of transplantation in stem cell transplants utilizing single umbilical cord blood, double umbilical cord blood, or umbilical cord blood plus haploidentical stem cells. [Leuk Lymphoma] Abstract Human Umbilical Cord Blood Mononuclear Cells and Chorionic Plate-Derived Mesenchymal Stem Cells Promote Axon Survival in a Rat Model of Optic Nerve Crush Injury A rat model of optic nerve crush (ONC) injury was established in order to examine the effects of transplanting human chorionic plate-derived mesenchymal stem cells isolated from the placenta, as well as human umbilical cord blood mononuclear cells on compressed rat optic nerves. [Int J Mol Med] Abstract |