Cord Blood News Volume 8.21 | Jun 2 2016

TOP STORY

Specific Combinations of Donor and Recipient KIR-HLA Genotypes Predict for Large Differences in Outcome after Cord Blood Transplantation

Scientists studied clinical data, killer-cell immunoglobulin-like receptors (KIR) and HLA genotypes and natural killer-cell reconstitution in cord blood transplantation patients. [Blood] Abstract

(Ranked by impact factor of the journal)

Human Amniotic Fluid Stem Cells Labeled with Up-Conversion Nanoparticles for Imaging-Monitored Repairing of Acute Lung Injury

Scientists examined the effect of human amniotic fluid stem cells labeled with dual-polymer-coated UCNP-PEG-PEI nanoparticles in a murine model of acute lung injury. [Biomaterials] Abstract

PGE₂ Maintains Self-Renewal of Human Adult Stem Cells via EP2-Mediated Autocrine Signaling and Its Production Is Regulated by Cell-to-Cell Contact

Scientists investigated the autocrine effect of Prostaglandin E₂ (PGE₂) on human adult stem cells from cord blood or adipose tissue, and the regulation of its production by cell-to-cell contact, followed by the determination of its immunomodulatory properties. [Sci Rep] Full Article

Mesenchymal Stromal Cells from Human Umbilical Cords Display Poor Chondrogenic Potential in Scaffold-Free Three Dimensional Cultures

Researchers investigated the chondrogenic potential of mesenchymal stromal cells isolated from whole sections of human umbilical cord or mixed cord, and compared them with cells isolated from synovial membrane, Hoffa’s fat pad and cartilage. [Eur Cell Mater] Abstract

Unveiling the Differences of Secretome of Human Bone Marrow Mesenchymal Stem Cells, Adipose Tissue Derived Stem Cells and Human Umbilical Cord Perivascular Cells: A Proteomic Analysis

The authors performed a comparative proteomic-based analysis through mass spectrometry on the secretome of human mesenchymal stem cells derived from bone marrow, adipose tissue and human umbilical cord perivascular cells. [Stem Cells Dev] Abstract

Mechanoresponsiveness of Human Umbilical Cord Mesenchymal Stem Cells in In Vitro Chondrogenesis – A Comparative Study with Growth Factor Induction

Investigators elucidated the effect of dynamic mechanical compression in modulating the chondrogenic differentiation of human umbilical cord matrix mesenchymal stem cells. [J Biomed Mater Res A] Abstract

Impact of Cord Blood Banking Technologies on Clinical Outcome: A Eurocord/Cord Blood Committee (CTIWP), European Society for Blood and Marrow Transplantation and NetCord Retrospective Analysis

An extensive set of data concerning cord blood units banking were collected and correlations with clinical outcome were assessed. Clinical endpoints were transplant-related mortality, engraftment, and graft-versus-host disease. [Transfusion] Abstract

Enhanced Differentiation of Human Amniotic Fluid-Derived Stem Cells into Insulin-Producing Cells In Vitro

The authors investigated the ability of human amniotic fluid stem cells to differentiate into insulin-producing cells. [J Diabetes Investig] Abstract

Role of Stem Cell Factor in the Placental Niche

Stem cell factor (SCF) is a cytokine found in hematopoietic stem cells and causes proliferation and differentiation of cells by binding to its receptor (c-kit). The authors discuss the role of SCF in the placental niche. [Cell Tissue Res] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Regen BioPharma, Inc. Announces ucVax: Universal Donor Cancer Cellular Immunotherapy

Regen BioPharma, Inc. announced initiation of a preclinical development program aimed at creating the first cord blood based cancer immunotherapeutic product leveraging its NR2F6 immunological checkpoint. [Regen BioPharma, Inc. (PR Newswire Association LLC.)] Press Release

Syros Pharmaceuticals Announces FDA Acceptance of IND to Advance SY-1425 into Phase II Clinical Trial

Syros Pharmaceuticals announced that the U.S. Food and Drug Administration (FDA) accepted the company’s investigational new drug application to advance its lead drug candidate, SY-1425, a potent and selective retinoic acid receptor alpha agonist, into a Phase II clinical trial in genomically defined subsets of patients with relapsed or refractory acute myeloid leukemia and relapsed high-risk myelodysplastic syndrome identified through its platform [Syros Pharmaceuticals] Press Release

NEW 34^th International Congress of the International Society of Blood Tranfusion (ISBT)
September 3-8, 2016
Dubai, United Arab Emirates

Visit our events page to see a complete list of events in the cord blood community.

NEW Postdoctoral Researcher – Targeting the Bone Marrow Microenvironment for Drug Resistant AML (NUI Galway)

Scientific Communications and Publishing Coordinator (STEMCELL Technologies Inc.)

Technical Sales Representative (STEMCELL Technologies Inc.)

Research Assistants and Associates – Leukemia and Stem Cell Biology (King’s College London)

Postdoctoral Research Associate – Myeloid Leukemia (Upstate Medical University)

Postdoctoral Positions – Stem Cell Biology and Regenerative Medicine (University of Southern California)

Postdoctoral Research Associate – TAM-Family Kinases in Leukemogenesis (Emory University)

Postdoctoral Fellow – Hematopoietic Stem Cells (University of Pennsylvania)

Associate Scientist – Hematopoietic Stem Cell Biology (Editas Medicine)

Postdoctoral Fellow – Hematology/Oncology (Boston Children’s Hospital)

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