Cord Blood News 8.23 June 16, 2016 | |
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TOP STORYScientists showed a novel microRNA-mediated strategy of retina differentiation from somatic stem cells, which are potential allogeneic cell sources. Human amniotic epithelial stem cells and umbilical cord blood-derived mesenchymal stem cells treated with a retina differentiation cocktail induced gene expressions of retina development-relevant genes. [Oncotarget] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists showed that the inducible hepatocyte growth factor (HGF)-expressing hUCB-MSCs are competent to continuously express and secrete HGF in a controlled manner. [Mol Ther] Abstract The authors hypothesized that treatment with Wharton’s jelly-derived mesenchymal stem cells would protect renal, hepatic, and endothelial function in a cecal ligation and puncture model of sepsis in rats. [Stem Cells Transl Med] Abstract Investigators demonstrated that calcitonin gene-related peptide, a neural peptide synthesized in spinal cord, can dramatically aid the homing of human umbilical cord mesenchymal stem cells in spinal cord-transected spinal cord injury rats. [Sci Rep] Full Article Scientists assessed the long-term safety of allogeneic umbilical cord mesenchymal stem cells transplantation for patients with refractory systemic lupus erythematosus. [Clin Exp Med] Abstract The authors investigated whether harvesting and donor characteristics affected yield and neuronal differentiation, and compared human umbilical cord blood and Wharton’s jelly-derived mesenchymal stem cells regarding neuronal differentiation and cytokine secretion. [Regen Med] Abstract Researchers previously reported that CD133+ cells, endothelial progenitor cells derived from human umbilical cord blood, induce nerve extension in an ex vivo hypoxic-ischemic encephalopathy model. Here, they used an in vivo model to examine the effect of CD133+ cells in neonatal hypoxic-ischemic encephalopathy. [Life Sci] Abstract The authors describe the first reported case of a highly aggressive and metastatic inflammatory myofibroblastic tumors (secondary malignancy) in an eight-year-old girl following umbilical cord blood transplant. [J Pediatr Hematol Oncol] Abstract | |
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REVIEWSChallenges remain in improving the safety and efficacy of hematopoietic stem cell transplant from alternate donors. Early results from gene therapy may provide another curative option in patients with sickle cell disease. These approaches show early promise, but larger, longitudinal studies are needed to better determine the optimal clinical circumstances for transplant in sickle cell disease. [Br J Haematol] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field.
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INDUSTRY NEWSBloodCenter of Wisconsin and San Diego Blood Bank Announce Collaborative Offering Called Celluvative BloodCenter of Wisconsin and the San Diego Blood Bank have created a strategic partnership to accelerate advancements in research and patient care. [Celluvative] Press Release GlycoMimetics, Inc. announced that it received Fast Track designation from the U.S. Food and Drug Administration (FDA) for its novel E-selectin antagonist GMI-1271 for treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) and elderly patients aged 60 years or older with AML. [GlycoMimetics, Inc.] Press Release | |
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EVENTSNEW 21st Annual Congress of Asia Pacific Blood and Marrow Transplantation Group 2016 (APBMT 2016) Visit our events page to see a complete list of events in the cord blood community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Tumor Microenvironment and Cancer Stem Cells (Duke University) Technical Sales Representative (STEMCELL Technologies Inc.) Postdoctoral Research Position – Pediatric Hematology and Oncology (Hannover Medical School) Research Assistants and Associates – Leukemia and Stem Cell Biology (King’s College London) Postdoctoral Research Associate – Myeloid Leukemia (Upstate Medical University) Postdoctoral Research Associate – TAM-Family Kinases in Leukemogenesis (Emory University) Associate Scientist – Hematopoietic Stem Cell Biology (Editas Medicine) Postdoctoral Fellow – Hematology/Oncology (Boston Children’s Hospital) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Cord Blood News Volume 8.23 | Jun 16 2016