Cord Blood News 8.28 July 21, 2016 | |
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TOP STORYStem Cell Scientists Discover Genetic Switch to Increase Supply of Stem Cells from Cord Blood Researchers have discovered the switch to harness the power of cord blood and potentially increase the supply of stem cells for cancer patients needing transplantation therapy to fight their disease. [Press release from the University of Health Network discussing online prepublication in Cell Stem Cell] Press Release | Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists showed that the inducible hepatocyte growth factor (HGF)-expressing human umbilical cord blood-derived-mesenchymal stem cells (MSCs) are competent to continuously express and secrete HGF in a controlled manner. [Mol Ther] Abstract The role of Wharton’s jelly-derived human mesenchymal stem cells in inhibiting muscle cell death was elucidated. [Mol Ther] Abstract Scientists evaluated the therapeutic effect of mesenchymal stromal cells-based cell transplantation as an alternative treatment for liver fibrosis. [Stem Cells Transl Med] Abstract A preparation of mesenchymal stromal cells derived from full-term human placenta (PDMSCs) is a new approach in the treatment of patients with multiple sclerosis. Human PDMSCs demonstrated striking therapeutic effects when delivered at the onset or at the peak of the disease. [Cytotherapy] Abstract Investigators tested three novel hypotheses: 1) Nicotinamide (NAM) increases the adipogenic response of human umbilical cord tissue-derived mesenchymal stem cells through a SIRT1 and PPARγ pathway; 2) lipid potentiates the NAM-enhanced adipogenic response; and 3) the adipogenic response to NAM is associated with increased percent fat mass among neonates. [PLoS One] Full Article Scientists examined human amniotic fluid stem cells, one of the potential sources of multipotent stem cells isolated from both cell pellet (using single-stage method), and supernatant of human amniotic fluid. [PLoS One] Full Article The authors demonstrated that Pam3Csk induced the secretion of pro‑inflammatory molecules, and increased the expression levels of cytokine and chemokines in umbilical cord mesenchymal stem cells. [Mol Med Rep] Abstract | |
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REVIEWSThe authors discuss aspects of platelet lysate (PL) as mesenchymal stem/stromal cell culture supplement as a preliminary step towards an agreed definition of the required characteristics of PL for the requirements of manufacturers and users. [Stem Cell Res Ther] Full Article Visit our reviews page to see a complete list of reviews in the cord blood research field.
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INDUSTRY NEWSPluristem Advances Its U.S. FDA Trial in Hematologic Indication Pluristem Therapeutics Inc. announced it has advanced its Phase I trial of PLX-R18 cells to treat insufficient hematopoietic recovery following hematopoietic cell transplantation by contracting with a leading global clinical research organization. [Pluristem Therapeutics Inc.] Press Release Damon Runyon Cancer Research Foundation Awards over $4 Million to 10 Top Clinical Investigators The Damon Runyon Cancer Research Foundation named seven new Damon Runyon Clinical Investigators at its spring 2016 Clinical Investigator Award Committee review. The recipients of this prestigious three-year award are outstanding early career physician-scientists conducting patient-oriented cancer research at major research centers under the mentorship of the nation’s leading scientists and clinicians. [Damon Runyon Cancer Research Foundation] Press Release | |
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POLICY NEWSChinese Scientists to Pioneer First Human CRISPR Trial Chinese scientists are on the verge of being first in the world to inject people with cells modified using the CRISPR–Cas9 gene-editing technique. A team led by Lu You, an oncologist at Sichuan University’s West China Hospital in Chengdu, plans to start testing such cells in people with lung cancer next month. [Nature News] Editorial First Greek Science Agency Is Rare Source of Joy for Beleaguered Researchers A massive loan from the European Union’s investment bank gives Greek researchers their first ray of hope since the debt crisis hit six years ago: a government-backed plan to create a Greek research agency. [Nature News] Editorial Dutch Agency Launches First Grants Program Dedicated to Replication The Netherlands has launched what researchers say is the world’s first national fund dedicated to replication studies: a pot of €3 million over the next 3 years for Dutch scientists to test whether they can reproduce important research results in social and medical sciences. [Nature News] Editorial
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EVENTSNEW 3rd Stem Cells Conference (IV IPLASS Meeting) Visit our events page to see a complete list of events in the cord blood community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Cancer Genomics (Ohio State University) NEW Postdoctoral Position – Genomics of Therapy-Related Myeloid Neoplasms (University of Chicago) Assistant Member Faculty – PlatinumImmunotherapy (Fred Hutchinson Cancer Research Center) Cell Biologist – Mesenchymal Stem Cells (Biostage) Technical Sales Representative (STEMCELL Technologies Inc.) PhD Studentship – Various Projects (Vienna Biocenter) Postdoctoral Fellow – Characterizing and Targeting Cancer Stem Cells (City of Hope) Postdoctoral Fellow – Tumor Microenvironment and Cancer Stem Cells (Duke University) Research Assistants and Associates – Leukemia and Stem Cell Biology (King’s College London) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Cord Blood News Volume 8.28 | Jul 21 2016