Cord Blood News Volume 8.29 | Jul 28 2016

TOP STORY

IL-10⁺ Regulatory B Cells Are Enriched in Cord Blood and May Play a Role in Protection against GvHD after Cord Blood Transplantation

Investigators demonstrated that cord blood contains an abundance of B cells with immunoregulatory function. IL-10-producing regulatory B cells were identified in both the naive and transitional B cell compartments and suppressed T-cell proliferation and effector function through IL-10 production as well as cell-to-cell contact involving CTLA-4. [Blood] Abstract

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Mesenchymal Stem Cells Deliver and Release Conditionally Replicative Adenovirus Depending on Hepatic Differentiation to Eliminate Hepatocellular Carcinoma Cells Specifically

Investigators developed a conditionally replicative adenovirus (CRAd) loaded on human umbilical cord-derived mesenchymal stem cells, in which the CRAd contained an adenovirus E1A gene dual regulated by α-fetoprotein promoter and microRNA-122 target sequence. [Cancer Lett] Abstract

Knocking down of Heat-Shock Protein 27 Directs Differentiation of Functional Glutamatergic Neurons from Placenta-Derived Multipotent Cells

Scientists presented human placenta-derived multipotent cells as a source from which functional glutamatergic neurons can be derived. [Sci Rep] Full Article

The Human Amniotic Fluid Stem Cell Secretome Effectively Counteracts Doxorubicin-Induced Cardiotoxicity

Investigators showed that, following hypoxic preconditioning, human amniotic fluid-derived stem cells conditioned medium antagonizes senescence and apoptosis of cardiomyocytes and cardiac progenitor cells, two major features of doxorubicin cardiotoxicity. [Sci Rep] Full Article

In Vitro Characterization of Neurite Extension Using Induced Pluripotent Stem Cells Derived from Lissencephaly Patients with TUBA1A Missense Mutations

Researchers generated induced pluripotent stem cells from the umbilical cord and peripheral blood of two lissencephaly patients with different clinical severities carrying alpha tubulin (TUBA1A) missense mutations [Mol Brain] Full Article

Effects of Pharmacological Agents on Human Amniotic Fluid Derived Stem Cells in Culture

Amniotic fluid cells are made up of a heterogeneous population of fetal cells that can be retrieved during pregnancy without ethical concerns as it is a standard clinical procedure. Studies of proliferation, multipotent marker expression, differentiation, and gene expression were performed after culturing with dexamethasone, valproic acid and magnesium sulfate. [Stem Cells Dev] Abstract

Feasibility of Human Amniotic Fluid Derived Stem Cells in Alleviation of Neuropathic Pain in Chronic Constrictive Injury Nerve Model

Scientists assessed the potentiality of human amniotic fluid derived mesenchymal stem cells for alleviating the neuropathic pain in a chronic constriction nerve injury model. [PLoS One] Full Article

Ultrastructural Demonstration of Cx43 Gap Junctions in Induced Pluripotent Stem Cells from Human Cord Blood

The authors investigated expression of Cx43 in undifferentiated human cord-blood-derived induced pluripotent stem cells. For this purpose, they carried out quantitative real-time PCR and immunohistochemistry. [Histochem Cell Biol] Abstract

Advances in Understanding the Mechanisms of Erythropoiesis in Homeostasis and Disease

The authors summarize studies describing novel regulators of erythropoiesis that modulate erythroid cell production in the context of human erythroid disorders involving hypoxia, iron regulation, immune-related molecules, and the transcription factor FOXO3. [Br J Haematol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Four Young Pediatric Cancer Research Fellows Earn $1 Million in New Awards

The Damon Runyon Cancer Research Foundation has named four outstanding young scientists as recipients of the prestigious Damon Runyon-Sohn Pediatric Cancer Research Fellowship Award, committing nearly $1 million to help address a critical shortage of funding for pediatric cancer research. [The Damon Runyon Cancer Research Foundation] Press Release

Gamida Cell Announces First Patient with Sickle Cell Disease Transplanted in Phase I/II Study of CordIn™ as the Sole Graft Source

Gamida Cell announced that the first patient with sickle cell disease has been transplanted with CordIn™. [Gamida Cell] Press Release

Apogenix Granted European Patent for the Use of APG101 in the Treatment of Myelodysplastic Syndromes

Apogenix announced that the European Patent Office has granted the company a patent for the use of CD95 ligand inhibitors including APG101 in the treatment of myelodysplastic syndromes. [Apogenix] Press Release

Science Advice for Europe

Exactly one month after Britain’s momentous decision to leave the European Union, around 4500 scientists and friends of science will assemble in Manchester, UK, for the opening of the EuroScience Open Forum, Europe’s largest interdisciplinary research conference. [Science] Editorial

Trump vs Clinton: Worlds Apart on Science

Science is slowly coming into focus in the US presidential campaign. Although neither Republican Donald Trump nor Democrat Hillary Clinton has emphasized core research issues, the candidates — and their parties — are beginning to flesh out their positions on climate change, education, biomedical research and other topics that involve the scientific community. [Nature News] Editorial

NEW World Stem Cell Summit 2016
December 6-9, 2016
West Palm Beach, United States

Visit our events page to see a complete list of events in the cord blood community.

NEW Postdoctoral Fellow – Hematopoietic Stem Cells (University of Pennsylvania)

NEW Postdoctoral Position – Organogenesis and Mesenchymal Stem Cells (University of Southern California)

Technical Sales Representative (STEMCELL Technologies Inc.)

Postdoctoral Position – Cancer Genomics (Ohio State University)

Postdoctoral Position – Genomics of Therapy-Related Myeloid Neoplasms (University of Chicago)

Assistant Member Faculty – PlatinumImmunotherapy (Fred Hutchinson Cancer Research Center)

Cell Biologist – Mesenchymal Stem Cells (Biostage)

Postdoctoral Research Fellow – Molecular and Cellular Basis of Hematopoiesis (Cincinnati Children’s Hospital Medical Center)

PhD Studentship – Various Projects (Vienna Biocenter)

Postdoctoral Fellow – Tumor Microenvironment and Cancer Stem Cells (Duke University)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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