Cord Blood News Volume 8.32 | Aug 18 2016

TOP STORY

Multiple Allogeneic Progenitors in Combination Function as a Unit to Support Early Transient Hematopoiesis in Transplantation

Investigators modeled an insufficient dose cord blood transplantation setting in lethally irradiated mice and then added hematopoietic stem/progenitor cells derived from four mouse allogeneic strains. [J Exp Med] Abstract

(Ranked by impact factor of the journal)

Exendin-4 Enhances the Differentiation of Wharton’s Jelly Mesenchymal Stem Cells into Insulin-Producing Cells through Activation of Various β-Cell Markers

Exendin-4 improved the differentiation outcome of Wharton’s jelly mesenchymal stem cells into insulin-producing cells, possibly through the ability to induce the expression of β-cell markers. [Stem Cell Res Ther] Abstract

Human Umbilical Cord-Derived Mesenchymal Stem Cells Protect against Experimental Colitis via CD5⁺ B Regulatory Cells

Human umbilical cord-derived mesenchymal stem cells protected against experimental colitis by boosting the numbers of CD5⁺ B cells and IL-10-producing CD5⁺ regulatory B cells, and correcting regulatory T cells/T helper (Th)17/Th1 imbalances. [Stem Cell Res Ther] Full Article

PD-1 Expression on CD4⁺ T Cells Predicts Mortality Following Allogenic Stem Cell Transplantation

To assess the role of the programmed death 1 (PD-1) pathway in allogeneic stem cell transplantation, researchers examined PD-1 expression and maturation phenotype on T cells from 42 patients early after cord blood, matched unrelated donor, and matched related donor transplantation. [Biol Blood Marrow Transplant] Abstract

Encapsulated Feeder Cells within Alginate Beads for Ex Vivo Expansion of Cord Blood-Derived CD34⁺ Cells

Mesenchymal stem cells isolated from different sources (human amniotic (hAMSCs) and umbilical cord (UCMSCs)), and human fibroblast cells (HFs) have been respectively chosen as feeder cells and the results showed that the hAMSCs were superior to UCMSCs and HFs in conventional two-dimensional co-cultures regarding the promotion of total nucleated cell expansion and the maintenance of the CD34⁺ phenotype. [Biomater Sci] Abstract

Immunotherapeutic Effects of Lymphocytes Co-Cultured with Human Cord Blood-Derived Multipotent Stem Cells Transplantation on APP/PS1 Mice

The authors found that APP/PS1 mice injected with lymphocytes co-cultured with cord blood-derived multipotent stem cells showed improved spatial learning, which significantly correlated with fewer amyloid-β plaques and less phosphorylated tau in brain. [Behav Brain Res] Abstract

Ginsenoside Rg1 Protects Human Umbilical Cord Blood-Derived Stromal Cells against Tert-Butyl Hydroperoxide-Induced Apoptosis through Akt-FoxO3a-Bim Signaling Pathway

Investigators aimed to investigate the effects of Ginsenoside Rg1 on protecting human umbilical cord blood-derived stromal cells from tert-butyl hydroperoxide-induced oxidative injury and apoptosis, as well as the possible signaling pathway involved. [Mol Cell Biochem] Abstract

Histone Deacetylase Inhibitors Induce Leukemia Gene Expression in Cord Blood Hematopoietic Stem Cells Expanded Ex Vivo

Researchers studied the ex vivo expansion of cord blood hematopoietic stem and progenitor cells by histone deacetylase inhibitors, trichostatin A and valproic acid. [Int J Hematol] Abstract

Allogeneic Stem Cell Transplantation for Sickle Cell Disease

The reviewers summarize results from trials of hematopoietic stem cell transplantation for children or adults with sickle cell disease using a variety of graft sources as well as conditioning and graft-versus-host disease prophylaxis regimens, and discuss the unique challenges that arise in these patients. [Curr Opin Hematol] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Bellicum Announces BPX-501 European Regulatory Updates

Bellicum Pharmaceuticals, Inc. announced that the European Commission has granted orphan drug designations for both its lead T-cell therapy product candidate BPX-501 for treatment in hematopoietic stem cell transplantation, and for activator agent rimiducid for the treatment of graft vs. host disease. [Bellicum Pharmaceuticals, Inc.] Press Release

Tissue Regeneration Therapeutics Engineered Mesenchymal Stromal Cells Advance Monoclonal Antibody Therapy

Tissue Regeneration Therapeutics Inc. (TRT) announced that a team of Canadian researchers has for the first time shown that TRT’s engineered mesenchymal stromal cell product can be used to deliver therapeutically useful monoclonal antibodies more effectively than administration of the mAbs themselves. [Tissue Regeneration Therapeutics Inc. (PR Newswire Association LLC)] Press Release

US Personalized-Medicine Industry Takes Hit from Supreme Court

Rejections for US patents related to personalized medicine have spiked after recent Supreme Court decisions tightened the rules for such claims, an analysis of more than 39,000 patent applications reveals. [Nature News] Editorial

EMA Adopts New Biologic, Biosimilar Pharmacovigilance Guidance

The European Medicines Agency (EMA) on Monday announced new recommendations for monitoring the safety of biologics and biosimilars. The guidance will take effect on 16 August 2016. [Regulatory Affairs Professionals Society] Editorial | Guideline

Spiking Genomic Databases with Misinformation Could Protect Patient Privacy

Large genomic databases are indispensable for scientists looking for genetic variations associated with diseases. But they come with privacy risks for people who contribute their DNA. A 2013 study showed that hackers could use publicly available information on the Internet to identify people from their anonymized genomic data. [Nature News] Editorial

NEW Advances in Cell Engineering, Imaging, and Screenings
November 17-18, 2016
Leuven, Belgium

Visit our events page to see a complete list of events in the community.

NEW Assistant Associate or Full Member Faculty – Myeloid Malignancies (Fred Hutchinson Cancer Research Center)

Technical Sales Representative (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Stem Cell Functions in the Hematopoietic System and Other Systems Derived from the Mesoderm (University of Illinois, Chicago)

Postdoctoral Position – Tumor Immunology (Roswell Park Cancer Institute)

Postdoctoral Fellow – Hematopoietic Stem Cells (University of Pennsylvania)

Postdoctoral Position – Organogenesis and Mesenchymal Stem Cells (University of Southern California)

Postdoctoral Position – Cancer Genomics (Ohio State University)

Assistant Member Faculty – PlatinumImmunotherapy (Fred Hutchinson Cancer Research Center)

Cell Biologist – Mesenchymal Stem Cells (Biostage)

PhD Studentship – Various Projects (Vienna Biocenter)

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