Cord Blood News 8.34 September 1, 2016 | |
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TOP STORYScientists demonstrated that H/ACA box small nucleolar RNA 7A is inversely correlated to the decreased proliferation rate during in vitro passaging of umbilical cord blood derived mesenchymal stem cells. [Stem Cells] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists generated a humanized immune system mouse model by transplanting human umbilical cord blood mononuclear cells into NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ mice after sublethal irradiation. [Oncotarget] Full Article Scientists evaluated the cumulative yield and the ex vivo amplification potential of mesenchymal stromal cells obtained from various sources and different subjects, using defined culture conditions with a standardized platelet lysate as growth stimulus. [Stem Cell Res Ther] Full Article Establishing a Tree Shrew Model of Systemic Lupus Erythematosus and Cell Transplantation Treatment Eighty tree shrews were randomly divided into four groups receiving either an intraperitoneal injection of pristane, lipopolysaccharide (LPS), or pristane and LPS, or no injection. Three weeks after injection, the systemic lupus erythematosus model tree shrews were divided into the model group and the treatment group. Tree shrews in the treatment group and the normal control group were infused with umbilical cord mesenchymal stem cells. [Stem Cell Res Ther] Full Article The authors investigated the efficacy of allogeneic hematopoietic stem cell transplantation in pediatric patients with mucopolysaccharidosis. [Biol Blood Marrow Transplant] Abstract The authors developed a new method of measuring total bisphenol A in whole blood samples by using isotopic dilution liquid chromatography-tandem mass spectrometry. For eliminating possible contaminations, they used glass cartridge instead of polypropylene cartridge and successfully reduced background levels. [Chemosphere] Abstract Lipids and Leukocytes in Newborn Umbilical Vein Blood, Birth Weight and Maternal Body Mass Index Researchers evaluated the relationship between maternal pre-pregnancy body mass index and weight gain during pregnancy, and newborn birth weight, with lipid profile, high-sensitivity C-reactive protein and leukocyte in newborns. [J Dev Orig Health Dis] Abstract Investigators evaluated the hypothesis that intramuscular transplantation of allogeneic mesenchymal stromal cells obtained from equine umbilical cord is safe, demonstrating that this is a suitable source of stem cells for therapeutic use. [Int J Stem Cells] Abstract | |
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REVIEWSMyelin Repair by Transplantation of Myelin-Forming Cells in Globoid Cell Leukodystrophy A practical strategy for myelin repair in globoid cell leukodystrophy would be to combine the rapid and widespread cross-correction of galactocerebrosidase (GALC) by hematopoietic stem cell transplantation with the robust, stable myelination provided by transplanted GALC-producing myelin-forming cells. This short review will discuss such possibilities. [J Neurosci Res] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSEurofins Scientific announced the acquisition of VRL Laboratories, one of the leading laboratories in pre-transplant testing for the eligibility determination for Donors of Human Cells, Tissues, and Cellular and Tissue-Based Products in the US. [Eurofins Scientific] Press Release MiMedx Provides Update on Key Clinical Trials MiMedx Group, Inc. provided an update on the status of key clinical trials. [MiMedx Group, Inc.] Press Release | |
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POLICY NEWSFDA Reaches Agreement with Generics Industry on New GDUFA Commitments The Food and Drug Administration and the generic drug manufacturing industry —including representatives of generic pharmaceutical manufacturers, active pharmaceutical ingredient manufacturers and contract manufacturing organizations — have reached agreement on a package of program enhancements and resource commitments to reauthorize the Generic Drug User Fee Amendments of 2012 (GDUFA), which are set to expire next year. [Drug Store News] Editorial NSF Proposes Changes in Use of Costly Rotators for Senior Positions The National Science Foundation (NSF) believes that having academics spend anywhere from two to four years at the agency before returning to campus helps it identify and fund cutting-edge research. Last year 176 scientists, about 28% of NSF’s scientific workforce, were on such temporary assignments. But NSF’s heavy use of these so-called rotators is unique among government research agencies. And some members of Congress are worried that the government is paying too steep a price for that management strategy. [ScienceInsider] Editorial
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EVENTSNEW 9th Stem Cell Clonality Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD Position – Tumor Microenvironment in Leukemia (Georg-Speyer-Haus) NEW Senior Research Scientist – Cancer Research (Anthony Nolan Trust) Technical Sales Representative (STEMCELL Technologies Inc.) Research Fellow – Cancer Biology (University of Michigan) Postdoctoral Position – Tumor Immunology (Roswell Park Cancer Institute) Postdoctoral Fellow – Hematopoietic Stem Cells (University of Pennsylvania) Postdoctoral Position – Organogenesis and Mesenchymal Stem Cells (University of Southern California) Postdoctoral Position – Cancer Genomics (Ohio State University) Assistant Member Faculty – PlatinumImmunotherapy (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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