Cord Blood News Volume 8.39 | Oct 6 2016

TOP STORY

Contributions of Mouse and Human Hematopoietic Cells to Remodeling of the Adult Auditory Nerve after Neuron Loss

Experiments were performed using both a mouse-mouse bone marrow transplantation model and a severely immune-incompetent mouse model transplanted with human CD34⁺ cord blood cells. Quantitative immunohistochemical analysis of recipient mice demonstrated that ouabain injury promoted an increase in the number of both hematopoietic stem cell (HSC)-derived macrophages and HSC-derived nonmacrophages in the auditory nerve. [Mol Ther] Full Article

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Efficient Long-Term Cryopreservation of Pluripotent Stem Cells at −80 °C

A medium comprised of Ficoll 70 and dimethyl sulfoxide in presence or absence of fetal bovine serum can provide reliable cryopreservation of various kinds of human and porcine pluripotent stem cells at −80 °C for periods that extend up to at least one year, with the post-thaw viability. [Sci Rep] Full Article

Umbilical Cord-Derived Mesenchymal Stem Cells Reversed the Suppressive Deficiency of T Regulatory Cells from Peripheral Blood of Patients with Multiple Sclerosis in a Co-Culture – A Preliminary Study

Researchers investigated whether umbilical cord-derived mesenchymal stem cells (UC-MSCs) could improve the impaired function of T regulatory cells from multiple sclerosis (MS) patients. Co-cultures of UC-MSCs with PBMCs of MS patients were performed for three days. [Oncotarget] Full Article

Human Umbilical Cord Derivatives Regenerate Intervertebral Disc

Researchers investigated the feasibility and efficacy of human umbilical cord mesenchymal stem cells and chondroprogenitor cells derived from those cells to regenerate damaged intervertebral disc in a rabbit model. [J Tissue Eng Regen Med] Abstract

Therapeutic Angiogenesis Induced by Human Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells in a Murine Model of Hindlimb Ischemia

Scientists demonstrated that UCX^® enhances angiogenesis in vitro via a paracrine effect. Importantly, after induced hindlimb ischemia induction, UCX^® improve blood perfusion by stimulating angiogenesis and arteriogenesis. [Stem Cell Res Ther] Full Article

Epigenetic Signatures at the RUNX2-P1 and Sp7 Gene Promoters Control Osteogenic Lineage Commitment of Umbilical Cord-Derived Mesenchymal Stem Cells

Via quantitative PCR profiling and chromatin immunoprecipitation studies the authors analyzed the ability of Wharton’s Jelly mesenchymal stem cells to engage osteoblast lineage. [J Cell Physiol] Abstract

Umbilical Cord-Derived Mesenchymal Stem Cell Transplantation in Hepatitis B Virus Related Acute-on-Chronic Liver Failure Treated with Plasma Exchange and Entecavir: A 24-Month Prospective Study

The authors investigated the efficacy of umbilical cord-derived mesenchymal stem cell transplantation in patients with hepatitis B virus related acute-on-chronic liver failure. [Stem Cell Rev] Abstract

Isolation, Characterization and Immunomodulatory-Associated Gene Transcription of Wharton’s Jelly-Derived Multipotent Mesenchymal Stromal Cells at Different Trimesters of Cow Pregnancy

Investigators demonstrated that Wharton’s jelly multipotent stromal cells harvested from the bovine umbilical cord at different gestational stages showed proliferative capacity, immune privilege and stemness potential. [Cell Tissue Res] Abstract

The Effect of Transplanted Human Wharton’s Jelly Mesenchymal Stem Cells Treated with IFN-γ on Experimental Autoimmune Encephalomyelitis Mice

Scientists evaluated the therapeutic effects of interferon (IFN)-γ primed Wharton’s jelly mesenchymal stem cells (WJ-MSCs) in experimental autoimmune encephalomyelitis (EAE) mice. IFN-γ primed WJ-MSCs were injected on days 3 and 11 after EAE induction. [Cell Immunol] Abstract

Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Liver Injury: Hepatoprotective Efficacy, Subchronic Toxicity, Tumorigenicity, and Biodistribution

Investigators evaluated the efficacy of human umbilical cord-derived mesenchymal stem cells on carbon tetrachloride-induced acute liver injury. In addition, its toxicity, tumorigenicity, and biodistribution were determined. [Regul Toxicol Pharmacol] Abstract

Bioactive Molecules Derived from Umbilical Cord Mesenchymal Stem Cells

The authors discuss umbilical cord mesenchymal stem cell biological characteristics, their secretome-based therapeutic mechanism, and potential applications. [Acta Histochem] Abstract

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Advances in Regenerative Medicine with MiMedx EpiFix^® and AmnioFix^® to Be Presented

MiMedx Group, Inc. announced that seven poster abstracts showing the clinical and cost effective healing results of the company’s EpiFix and AmnioFix dehydrated Human Amnion/Chorion Membrane allografts will be presented. [Press release from MiMedx Group, Inc. discussing research to be presented at the 2016 Symposium on Advanced Wound Care Fall (SAWC Fall), Las Vegas] Press Release

BioBridge Global-Led Biotech Team Awarded $7.8 Million Army Contract

A four-organization biotech group led by San Antonio-based nonprofit BioBridge Global has been awarded a $7.8 million contract from the Medical Technology Enterprise Consortium. The funds will enable the development of large-scale manufacturing capabilities for clinical-grade stem cells for research and therapeutic use. [BioBridge Global] Press Release

San Diego Blood Bank and the National Blood Collaborative Receive Sub-Award to Support the U.S. Precision Medicine Initiative Cohort Program

As part of the most ambitious medical research program in the history of American medicine, the San Diego Blood Bank and the National Blood Collaborative have received a sub-award for their role in enrolling participant-volunteers into the national Precision Medicine Initiative Cohort Program. [National Blood Collaborative] Press Release

Dr. Allen Eaves of STEMCELL Technologies Inc. Named EY Entrepreneur Of The Year™ Pacific 2016

Dr. Allen Eaves, Chairman, President and Chief Executive Officer of STEMCELL Technologies, a global biotechnology company that supplies tools and services to enable life science research, is this year’s Entrepreneur Of The Year Pacific winner. [Ernst & Young (CNW Group Ltd.)] Press Release

Medicine Nobel for Research on How Cells ‘Eat Themselves’

Molecular biologist Yoshinori Ohsumi has won the 2016 Nobel Prize in Physiology or Medicine for his work in the field of autophagy: the processes by which the cell digests and recycles its own components. [Nature News] Editorial | Press Release

Brexit Government’s Anti-Immigration Stance Spooks UK Scientists

UK scientists say they’re dismayed by their new government’s toughened stance on curbing immigration, including ideas to restrict the flow of foreign students and workers. [Nature News] Editorial

Dramatic Twists Could Upend Patent Battle over CRISPR Genome-Editing Method

The 9-month-old patent battle over CRISPR, a novel genome-editing tool that could have immense commercial value, has taken two surprising twists. Last week, attorneys for the Broad Institute in Cambridge, Massachusetts, one of the research organizations vying for CRISPR rights, submitted motions that could let it win even if it loses. [Science Insider] Editorial

NEW The Biology of Regenerative Medicine
April 25-27, 2017
Hinxton, United Kingdom

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NEW Senior Research Scientist / Natural Killer Cell Therapy Group Leader – Immunotherapy (The Anthony Nolan Trust)

Postdoctoral Fellow – Blood Coagulation and Progenitor Cells (BloodCenter of Wisconsin)

Research Associate – Hematology (Editas Medicine)

Assistant Associate or Full Member Faculty Position – Myeloid Malignancies (Fred Hutchinson Cancer Research Center)

Postdoctoral Associate Position – Blood Cancer and Epigenetic Research (University of Miami)

Postdoctoral or Group Leader – Mechanisms Operating during Hematopoiesis and Leukemogenesis (Universität Tübingen)

Assistant, Associate or Full Professors – Hematologic Malignancies (Cincinnati Children’s Hospital Medical Center)

Postdoctoral Position – Experimental Hematology and Cancer Biology (Cincinnati Children’s Hospital Medical Center)

Chair – Medical Biology (Masaryk University)

PhD Position – Tumor Microenvironment in Leukemia (Georg-Speyer-Haus)

Research Fellow – Cancer Biology (University of Michigan)

Assistant Associate or Full Member Faculty – Myeloid Malignancies (Fred Hutchinson Cancer Research Center)

Assistant Member Faculty – PlatinumImmunotherapy (Fred Hutchinson Cancer Research Center)

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