Cord Blood News 8.41 October 20, 2016 | |
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TOP STORYScientists find that hematopoietic CD34+ cells in spin embryoid bodies derived from human embryonic stem cells lack HOXA expression compared with repopulation-competent human cord blood CD34+ cells, indicating incorrect mesoderm patterning. [Nat Biotechnol] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Hematopoietic Stem Cell Transplantation Corrects WIP Deficiency Investigators found that WIP deficiency causes autosomal recessive Wiskott – Aldrich syndrome with normal platelet mean volume and can be cured with hematopoietic stem cell transplantation from genoidentical related or unrelated umbilical cord. [J Allergy Clin Immunol] Abstract Impact of Graft-versus-Host Disease on Outcomes after Unrelated Cord Blood Transplantation Researchers analyzed the impact of acute and chronic graft-versus-host disease (GVHD) on outcomes in adult patients with acute leukemia or myelodysplastic syndrome who underwent their first unrelated cord blood transplantation. The effect of GVHD on outcomes was analyzed after adjusting for other significant variables. [Leukemia] Abstract Scientists used IHC on human tumor specimens or normal tissue to determine the expression and distribution of ubiquitin-like with PHD and ring finger domains 2 (UHRF2), Ki-67, and 5-hydroxymethylcytosine. They also examined UHRF2 expression in cord blood progenitors and compared its expression to methylation status in 6 leukemia cell lines and 15 primary human leukemias. [Oncotarget] Full Article Investigators showed that ct-CD45 is abundant in human peripheral blood plasma from healthy adults compared with plasma derived from umbilical cord blood and plasma from patients with rheumatoid arthritis or systemic lupus erythematosus. [Eur J Immunol] Abstract The Newborn Human NK Cell Repertoire Is Phenotypically Formed but Functionally Reduced The authors used mass cytometry to provide a comprehensive comparison of natural killer (NK) cells from umbilical cord blood and adult peripheral blood. [Cytometry B Clin Cytom] Abstract BDNF Expression Is Up-Regulated by Progesterone in Human Umbilical Cord Mesenchymal Stem Cells Scientists investigated whether promotion of neuronal differentiation of human umbilical cord mesenchymal stem cells by progesterone involves changes in brain-derived neurotrophic factor (BDNF) levels. [Neurol Res] Abstract | |
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REVIEWSRecent Discoveries Concerning the Tumor – Mesenchymal Stem Cell Interactions The goal of this review is to synthesize recent and emerging discoveries concerning the mechanisms by which mesenchymal stem cells (MSCs) can be attracted to tumor sites, how they can generate cancer associated fibroblasts CAFs and by which way MSCs are able to modulate the growth, response to treatments, angiogenesis, invasion and metastasis of tumors. [Biochim Biophys Acta] Full Article Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSCynata’s MSC Technology Demonstrates Significant Efficacy in Preclinical Asthma Study Cynata Therapeutics Limited announced that it has received compelling data from a proof of concept study of its Cymerusâ„¢ mesenchymal stem cells (MSCs) in an experimental model of asthma. [Cynata Therapeutics Limited] Press Release Iowa State Nets $9.6 Million to Increase STEM Diversity, Prepare Future Faculty Iowa State University has received nearly $10 million in funding from the National Science Foundation to improve diversity in both the professional STEM workforce and academia. [Iowa State University] Press Release | |
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POLICY NEWSEurope’s Drug Regulator Opens Vaults of Clinical-Trials Data In a move lauded as a landmark for transparency in medical science, the London-based European Medicines Agency (EMA) has begun to publish details of the full clinical-trial data that it receives from pharmaceutical companies. The disclosures make the EMA the first major drug regulatory agency to publish the warts-and-all results of clinical investigations that drug developers submit when they apply for the agency’s approval to market medicines in the EU. [Nature News] Editorial Reports of ‘Three-Parent Babies’ Multiply Claims of infants created using mitochondrial-replacement techniques stir scientific and ethical debate. [Nature News] Editorial How Republicans Reshaped the House Science Committee Lamar Smith has made his mark on science. As chairman of the US House Committee on Science, Space, and Technology, the Texas Republican has launched dozens of investigations into alleged wrongdoing by scientists, environmental groups and government officials. And he shows no signs of slowing down. [Nature News] Editorial
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EVENTSNEW Cord Blood to Help People with Spinal Cord Injury Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Vascular Biology (Universitatsklinikum Hamburg-Eppendorf) Postdoctoral Fellowship – Gene Regulation and Leukemia (Boston Children’s Hospital) Postdoctoral Fellow – Blood Coagulation and Progenitor Cells (BloodCenter of Wisconsin) Research Associate – Hematology (Editas Medicine) Postdoctoral Associate Position – Blood Cancer and Epigenetic Research (University of Miami) Chair – Medical Biology (Masaryk University) PhD Position – Tumor Microenvironment in Leukemia (Georg-Speyer-Haus) Research Fellow – Cancer Biology (University of Michigan) Assistant Member Faculty – PlatinumImmunotherapy (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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