Cord Blood News 8.44 November 10, 2016 | |
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TOP STORYImpact of Graft-versus-Host Disease on Outcomes after Unrelated Cord Blood Transplantation Investigators analyzed the impact of acute and chronic graft-versus-host disease (GVHD) on outcomes in adult patients with acute leukemia or myelodysplastic syndrome who underwent their first unrelated cord blood transplantation. The effect of GVHD on outcomes was analyzed after adjusting for other significant variables. [Leukemia] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Exosomes Derived from MSCs Ameliorate Retinal Laser Injury Partially by Inhibition of MCP-1 Researchers intravitreally injected mesenchymal stem cells (MSCs) derived from either mouse adipose tissue or human umbilical cord, and their exosomes to observe and compare their functions in a mouse model of laser-induced retinal injury. [Sci Rep] Full Article Therapeutic Effects of Umbilical Cord Blood Plasma in a Rat Model of Acute Ischemic Stroke Scientists demonstrated that both behavioral and structural impairments resulting from ischemic brain injury were significantly prevented/reversed after intravenous administration of umbilical cord blood plasma relative to the vehicle control. [Oncotarget] Abstract Umbilical cord blood (UCB) transplantation is associated with long periods of aplastic anemia. This undesirable situation is due to the low cell dose available per unit of UCB and the immaturity of its progenitors. To overcome this, the authors present a cell culture strategy aimed at the expansion of the CD34+ population and the generation of granulocyte lineage-committed progenitors. [N Biotechnol] Abstract Human Umbilical Cord Blood-Derived Neural Stem Cell Line as a Screening Model for Toxicity The authors investigated whether a human neural stem cell line derived from human umbilical cord blood can be used for toxicity study. [Neurotox Res] Abstract Researchers aimed to explore the feasibility of cartilage repair by human umbilical cord blood-derived mesenchymal stem cells (MSCs) and to determine the optimal concentrations of the MSCs in a rabbit model. [PLoS One] Full Article The authors demonstrated that human umbilical cord blood stem cells and M. officinalis are useful for the prevention of neurological disease. [ASN Neuro] Full Article Scientists found out whether the effect of sodium selenite and selenomethionine on telomerase activity in human umbilical cord-derived mesenchymal stem cells was associated with different levels of c-Myc and p53 expression. [DNA Cell Biol] Abstract Researchers retrospectively studied the impact of high-resolution allele matching at HLA-A, HLA-B, HLA-C, and HLA-DRB1 on transplant-related outcomes in 60 single-unit umbilical cord blood transplants in pediatric patients with malignant and nonmalignant conditions [J Pediatr Hematol Oncol] Abstract | |
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REVIEWSHuman MSCs are multilineage somatic progenitor/stem cells that have been shown to possess immunomodulatory properties in recent years. Initially met with much skepticism, MSC immunomodulation has now been well reproduced across tissue sources and species to be clinically relevant. [J Biomed Sci] Full Article Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSOver Half a Billion in Research Council Grant to Karolinska Institute (KI) Researchers The Swedish Research Council announced the grants it will be awarding in the category of medicine and health. The total sum is almost 980 million Swedish krona (SEK), of which KI researchers will receive SEK 524,325,017. [Karolinska Institute] Press Release LifeNet Health is expanding its cell-based research and processing capacity with the opening of a facility in North Carolina’s Research Triangle Park, near Durham. It will be an extension of its flagship research center, the LifeNet Health Institute of Regenerative Medicine, located at the company’s headquarters in Virginia Beach, Va. [LifeNet Health] Press Release | |
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POLICY NEWSNIH to Double Funding for Chronic Fatigue Syndrome, but Patient Distrust Remains NIH spending for research on the poorly understood disease should rise to roughly $15 million in 2017, doubling the estimated $7.6 million handed out in 2016. The biomedical agency will solicit CFS proposals from outside scientists to establish several collaborative centers for basic and clinical research, and another center to manage their data on the illness. The calls for applications, which will come with dedicated funds from the planned budget increase, are the first of their kind for CFS from the United States’s major medical research funder since 2005. [Science Insider] Editorial Donald Trump’s US Election Win Stuns Scientists Republican businessman and reality-television star Donald Trump will be the United States’ next president. Although science played only a bit part in this year’s dramatic, hard-fought campaign, many researchers expressed fear and disbelief as Trump defeated former secretary of state Hillary Clinton. [Nature News] Press Release The Quiet Rise of the NIH’s Hot New Metric Biomedical funders worldwide are adopting the US agency’s free Relative Citation Ratio to analyze grant outcomes. [Nature News] Press Release
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EVENTSNEW Advances in Stem Cells and Regenerative Medicine Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Stem Cell Biology and Hematology (University of São Paulo) Postdoctoral Position – Immunobiology of Stromal Cells (Institut Pasteur) MRC WIMM Prize PhD Studentships (University of Oxford) Postdoctoral Fellow – Vascular Biology (Universitatsklinikum Hamburg-Eppendorf) Research Associate – Hematology (Editas Medicine) Assistant Member Faculty – PlatinumImmunotherapy (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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