Cord Blood News 8.45 November 17, 2016 | |
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TOP STORYDistinct Signaling Programs Control Human Hematopoietic Stem Cell Survival and Proliferation Scientists describe experiments in which they used mass cytometry to simultaneously measure multiple surface markers, transcription factors, active signaling intermediates, viability and cell cycle indicators in single CD34+ cord blood cells before and up to two hours after their stimulation with SCF, FLT3L, IL3, IL6, and G-CSF either alone or combined. [Blood] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)First Steps to Define Murine Amniotic Fluid Stem Cell Microenvironment Investigators characterized the murine cKit+ cells present both in the amniotic fluid and in the amnion. To analyze the amniotic fluid stem cell microenvironment, they injected murine YFP+ embryonic stem cells into the amniotic fluid of E13.5 wild type embryos. [Sci Rep] Full Article Researchers harvested mesenchymal stem cells (MSCs) from adult bone marrow, adipose tissue, perinatal umbilical cord, and placental chorionic villi, and studied their “MSC identity” by flow cytometry and in vitro trilineage differentiation assay. They comparatively studied their endothelial differentiation capabilities and paracrine actions side by side in vitro. [Stem Cell Res Ther] Full Article Amnion Epithelial Cells Promote Lung Repair via Lipoxin A4 The authors aimed to assess the effects of human amnion epithelial cell (hAEC)-derived proresolution lipoxin-A4 on T-cell, macrophage, and neutrophil phenotype and function during the acute phase of bleomycin-induced lung injury. Using C57Bl6 mice, they administered 4 million hAECs intraperitoneally 24 hours after bleomycin challenge. [Stem Cells Transl Med] Abstract Wharton’s Jelly Mesenchymal Stem Cells Protect the Immature Brain in Rats and Modulate Cell Fate Given that mesenchymal stem/stromal cells (MSCs) emerged as a promising candidate for cell therapy, scientists transplanted MSCs derived from the Wharton`s jelly (WJ-MSCs) to reduce the burden of immature brain injury in a murine animal model. WJ-MSCs transplantation resulted in protective activity characterized by reduced myelin loss and astroglial activation. [Stem Cells Dev] Abstract Researchers describe how hetrombopag, an orally-active TPO receptor agonists, enhanced ex vivo expansion of human UCB stem cells, and protected cardiac myocytes from the damage caused by oxidative stress. [Cardiovasc Drugs Ther] Abstract The authors established stromal systems using HESS-5 murine bone marrow cells transfected with human Jagged-1 or human Dll-1. CD133+ cord blood cells were co-cultured with the stromal cells for seven days, and then their proliferation, differentiation, and endothelial progenitor cell colony formation was evaluated. [PLoS One] Full Article Tissue Engineering for Neurodegenerative Diseases Using Human Amniotic Membrane and Umbilical Cord The authors investigated the use of human amniotic mesenchymal stem cells, human amniotic epithelial stem cells, and human Wharton’s jelly mesenchymal stem cells derived from human umbilical cord as a source of stem cells, and the potential of the human amniotic membrane as a scaffold and/or source of growth factors to promote nerve regeneration. [Cell Tissue Bank] Abstract | |
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REVIEWSMesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor Microenvironment The authors discuss some of the evidence in hematological malignancies and solid tumors. In particular, they focus their attention on the means by which it is conceivable to inhibit mesenchymal stromal cell-mediated immune suppression and trigger anti-tumor innate immunity. [Vaccines] Full Article Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSAmericord Expands Cord Blood Banking Capacity Americord is reinforcing its commitment to providing state-of-the-art umbilical cord blood, cord tissue, and placenta tissue banking to its clients by securing additional capacity at a second cyropreservation laboratory. [Americord Registry (Business Wire, Inc.)] Press Release Golden Meditech Enters Into a Settlement Agreement with Sanpower Golden Meditech Holdings Limited announce that its wholly-owned subsidiary, GM Investment Company Limited, has entered into a conditional settlement agreement with Sanpower Group Limited regarding an outstanding amount of approximately US $250 million owed to Fortress Group Limited by Sanpower. [Golden Meditech Holdings Limited (PR Newswire Association LLC.)] Press Release | |
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POLICY NEWSArgentina President’s First Budget Angers Scientists Researchers in Argentina are incensed about budget cuts that look set to hit the nation’s science ministry especially hard next year—even though President Mauricio Macri pledged to boost science spending when he took office. [Nature News] Editorial Biomedical Research Leaders Urge Trump Administration to Quickly Appoint an NIH Director A science star–studded group that including two former directors of the National Institutes of Health (NIH) in Bethesda, Maryland, released a set of recommendations aimed at making NIH run better and offered advice on choosing an NIH director—ideally within Trump’s first 100 days in office. [Science Insider] Editorial In Bold New Step, Dutch Science Academy Holds Women-Only Elections In order to reduce its perpetual gender imbalance—87% of its 556 members are men—the Royal Netherlands Academy of Arts and Sciences seeks to recruit ten new members in 2017 and six more in 2018, all with two X chromosomes. [ScienceInsider] Editorial How Self-Appointed Guardians of “Sound Science” Tip the Scales toward Industry At a time when public mistrust of science runs high, and non-experts are hard-pressed to separate fact from industry-sponsored spin, Sense About Science, a charity based in London with an affiliate in New York, presents itself as a trustworthy arbiter. The organization purports to help the misinformed public sift through alarmist claims about public health and the environment by directing journalists, policymakers, and others to vetted sources who can explain the evidence behind debates about controversial products like e-cigarettes and flame retardants. [The Intercept] Editorial
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EVENTSNEW Regenerative Medicine Workshop at Hilton Head Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Leukemia Research (University Medicine Mannheim) Postdoctoral Position – Stem Cell Biology and Hematology (University of São Paulo) Postdoctoral Position – Immunobiology of Stromal Cells (Institut Pasteur) MRC WIMM Prize PhD Studentships (University of Oxford) Research Associate – Hematology (Editas Medicine) Assistant Member Faculty – PlatinumImmunotherapy (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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