Cord Blood News 8.49 December 15, 2016 | |
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TOP STORYScientists analyzed the effects of mesenchymal stem cells secretomes and potential anti-fibrotic proteins on transforming growth factor beta 1 mediated activation of human hepatic stellate cell (HSC) lines (hTert-HSC and LX2) and human primary HSCs. [Gastroenterology] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)hucMSC-Exosome Derived Gpx1 Is Required for the Recovery of Hepatic Oxidant Injury The authors used human umbilical cord mesenchymal stem cells (hucMSC) derived exosome administrated by tail vein or oral gavage at different doses and, in engrafted liver mouse models, noted antioxidant and anti-apoptotic effects, and rescue from liver failure. [Mol Ther] Full Article Researchers determined the impact of cryopreservation on caprine fetal adnexa derived mesenchymal stem cells on the basic stem cell characteristics. Cells were expanded to determine growth kinetics, tri-lineage differentiation, localization and molecular expression of mesenchymal stem cells and pluripotency markers; thereafter, these cells were transplanted in the full-thickness rat skin wound to determine their wound healing potential. [J Cell Physiol] Abstract Investigators described the reprogramming of CD34+ cells isolated from umbilical cord blood obtained after full term delivery of a healthy female child of Indian origin. [Stem Cell Res] Abstract Maternal Pre-Pregnancy BMI Downregulates Neonatal Cord Blood LEP Methylation The authors determined whether methylation changes in the LEP gene in cord blood DNA are impacted by the maternal environment or affect neonatal adiposity measures. [Pediatr Obes] Abstract Evaluation of Stem Cell-Derived Red Blood Cells as a Transfusion Product Using a Novel Animal Model Researchers generated ex vivo stem cell-derived red blood cells (RBCs) from primary human cord blood CD34+ cells and compared them to donor-derived RBCs based on a number of in vitro parameters. [PLoS One] Full Article A Cost-Effective Method to Assemble Biomimetic 3D Cell Culture Platforms Scientists present a combinatorial platform that integrates the human amniotic membrane with biomolecular, topographic and mechanical cues in one versatile model. [PLoS One] Full Article | |
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REVIEWSBased mainly on animal studies there is growing evidence to suggest that Toll-like receptors are involved in the development of chemotherapy-induced mucositis and in the propagation of graft versus host reactions as well as graft versus tumor effects in allogeneic hematopoietic stem cell transplantation (HSCT). In this review the authors discuss these findings along with the emerging, although still preliminary, clinical evidence, that points to a role of pattern recognition receptors in determining the outcome of HSCT and new therapeutic perspectives that may be related to this development. [Bone Marrow Transplant] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSCalifornia Cryobank Announces Acquisition of Donor Egg Bank USA California Cryobank (CCB) announced the acquisition of Donor Egg Bank USA. The transaction is being primarily financed through CCB investors Longitude Venture Partners II, L.P., NovaQuest Pharma Opportunities Fund III, L.P., and bank funding. The merger brings together two of the reproductive tissue industry’s leading organizations and establishes the world’s largest frozen donor gamete bank. [California Cryobank ( PR Newswire Association LLC.)] Press Release EMBO Installation Grants to Support Ten Researchers in Establishing Laboratories Ten life scientists have been awarded EMBO Installation Grants to set up independent research laboratories in the Czech Republic, Estonia, Poland, Portugal and Turkey. Installation Grants are awarded annually. They are funded primarily by the participating member states Czech Republic, Estonia, Poland, Portugal and Turkey. Grantees are selected by a committee of EMBO Members on the basis scientific excellence as the primary selection criterion. [EMBO] Press Release | |
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POLICY NEWSUnited Kingdom Gives Green Light for Mitochondrial Replacement Technique Authorities in the United Kingdom have given the go-ahead for mitochondrial replacement therapy, a new type of assisted reproduction that could allow some families to avoid passing on genetic disease. The technique is controversial because it combines genetic material from three people: two eggs and one sperm. The decision has been widely anticipated. It comes after years of debate and a change in the country’s laws passed by Parliament in 2015 [Science Insider] Editorial NIH Discusses Curbing Lab Size to Fund More Midcareer Scientists A new analysis by the National Institutes of Health in Bethesda, Maryland, reinforces previous studies showing that productivity may lag as labs get bigger. The results suggest that NIH could fund thousands more researchers without any drop-off in scientific output if it capped the total number of grants an investigator could receive, an NIH official says. [Science Insider] Editorial Is Donald Trump Pushing More Scientists towards Political Activism? Around the world, individual researchers and representatives of scientific societies are signing letters of protest or advice, offering to counsel Trump’s transition team and ramping up efforts to communicate the value of science to the public. [Nature News] Editorial Canada’s Government Scientists Get Antimuzzling Clause in Contract Scientists working for the Canadian government have successfully negotiated a clause in their new contract that guarantees their right to speak to the public and the media about science and their research, without needing approval from their managers. [ScienceInsider] Editorial
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EVENTSNEW 18th International Congress of Developmental Biology Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Position – Mesenchymal Stem Cells (University of Southern California) Principle Scientist – Translational Development (Celgene Corporation) MRC WIMM Prize PhD Studentships (University of Oxford) Research Associate – Hematology (Editas Medicine) Assistant Member Faculty – PlatinumImmunotherapy (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Cord Blood News Volume 8.49 | Dec 15 2016