Cord Blood News Volume 9.00 | Jan 5 2017

TOP STORY

Nanosized UCMSC-Derived Extracellular Vesicles but not Conditioned Medium Exclusively Inhibit the Inflammatory Response of Stimulated T Cells: Implications for Nanomedicine

Researchers used Size-Exclusion Chromatography to successfully isolate extracellular vesicles from umbilical cord mesenchymal stem cell (UCMSC)-conditioned medium. These vesicles were defined as positive for CD9, CD63, CD73 and CD90, and their size and morphology characterized by NTA and cryo-EM. [Theranostics] Full Article

(Ranked by impact factor of the journal)

Proteasome Activation Enhances Stemness and Lifespan of Human Mesenchymal Stem Cells

By employing both Wharton’s-Jelly- and Adipose-derived human adult mesenchymal stem cells, investigators revealed a significant age-related decline in proteasome content and peptidase activities, accompanied by alterations of proteasomal complexes. [Free Radic Biol Med] Abstract

Human Umbilical Cord Blood-Stem Cells Direct Macrophage Polarization and Block Inflammasome Activation to Alleviate Rheumatoid Arthritis

Researchers investigated the therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) as a new therapeutic strategy for patients with rheumatoid arthritis and to explore the mechanisms underlying hUCB-MSC-mediated immunomodulation. [Cell Death Dis] Full Article

Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice

Scientists found that intratracheal administration of human umbilical cord-mesenchymal stem cells significantly improved survival and attenuated the lung inflammation in lipopolysaccharide-induced acute lung injury mice. [Sci Rep] Full Article

Agouti Related Peptide Secreted via Human Mesenchymal Stem Cells Upregulates Proteasome Activity in an Alzheimer’s Disease Model

Scientists investigated the therapeutic potential of the Agouti-related peptide, which is secreted by human mesenchymal stem cells (MSCs), in terms of its effect on the regulation of proteasome activity in Alzheimer’s disease. When SH-SY5Y human neuroblastoma cells were co-cultured with MSCs isolated from human Wharton’s Jelly, their proteasome activity was significantly upregulated. [Sci Rep] Full Article

Aryl Hydrocarbon Receptor Activation by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Impairs Human B Lymphopoiesis

An in vitro B cell development model system was established by co-culturing human cord blood-derived hematopoietic stem cells with irradiated human primary bone marrow stromal cells. Using this in vitro model, investigators found that 2,3,7,8-tetrachlorodibenzo-p-dioxin significantly suppressed the total number of hematopoietic stem and progenitor cells in a concentration-dependent manner. [Toxicology] Abstract

Umbilical Cord Tissue–Derived Mesenchymal Stromal Cells Maintain Immunomodulatory and Angiogenic Potencies after Cryopreservation and Subsequent Thawing

Phenotype and immunomodulatory and angiogenic potencies of a specific umbilical cord tissue–derived mesenchymal stromal cell population were not impaired by cryopreservation and subsequent thawing, both in vitro and in vivo. [Cytotherapy] Abstract

Comparison of Two Methodologies for the Enrichment of Mononuclear Cells from Thawed Cord Blood Products: The Automated Sepax System versus the Manual Ficoll Method

Using Sepax, the authors observed higher recovery of total nucleated cells (TNC), CD34⁺ cells, natural killer cells and monocytes when compared to manual enrichment, despite similar TNC and CD34⁺ viability with the two methods. [Cytotherapy] Abstract

Characterization of Sox9-Overexpressing Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells-Based Engineered Cartilage Both In Vitro and In Vivo

Scientists evaluated the chondrogenesis of Sox9-overexpressing human umbilical cord mesenchymal stem cells seeded onto bone matrix gelatin/fibrin hybrid scaffolds both in vitro and in vivo. [J Biomed Mater Res A] Abstract

Amniotic Fluid Stem Cells: The Known, the Unknown and Potential Regenerative Medicine Applications

Although significant questions remain regarding the origin, heterogeneous phenotype and expansion potential of amniotic fluid stem cells, evidence to date supports their potential role as a valuable stem cell source for the field of regenerative medicine. [Stem Cells] Abstract

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China Cord Blood Corporation Receives Notice of Entry into Conditional Sale Agreement

China Cord Blood Corporation announced the company has been informed that Golden Meditech Holdings Limited, Golden Meditech Stem Cells Company Limited and Nanjing Ying Peng Hui Kang Medical Industry Investment Partnership entered into a conditional share purchase agreement on December 30, 2016, pursuant to which GM Stem Cells has agreed to sell to Nanjing Ying Peng approximately 65.4% of the company’s issued share capital on a fully diluted basis for RMB5,764 million in cash. [China Cord Blood Corporation] Press Release

Vivex Biomedical, Inc. Receives Level II HCPCS Q-Code for Cygnus™, a Human Amniotic Tissue Allograft

Vivex Biomedical, Inc. has received level II HCPCS Q-Code for Cygnus. Cygnus, an amniotic tissue matrix with innate regenerative capability to support healing, is a product that is available in multiple sizes for multiple uses. Cygnus’ amnion patch is an immune-privileged tissue with proven clinical success in regenerative healing. [Vivex Biomedical, Inc.] Press Release

US Scientists Fear New Restrictions on Fetal-Tissue Research

House Republicans conclude that tissue from aborted fetuses is of limited value for research and seek to reduce funding. [Nature News] Editorial

Argentina’s Researchers Occupy Science Ministry

Hundreds of young researchers occupied Argentina’s science ministry in Buenos Aires last month, angry at budget cuts that they say have denied them permanent jobs at the country’s National Scientific and Technical Research Council. The occupation was the most extreme action yet by Argentinian scientists after months of protests at last year’s budget, the first under President Mauricio Macri. And the occupation seems to have paid off, in part: many of those involved have been offered extensions to their fellowships. [Nature News] Editorial

Scientists in Germany, Peru and Taiwan to Lose Access to Elsevier Journals

Thousands of scientists in Germany, Peru and Taiwan are preparing for a new year without online access to journals from the Dutch publishing giant Elsevier. Contract negotiations in both Germany and Taiwan broke down in December, while Peru’s government has cut off funding for a licence. [Nature News] Editorial

NEW Standardization of the Hematopoietic Progenitor Assay Training Course
March 8-9, 2017
Dresden, Germany

NEW Applications of the Hematopoietic Progenitor Assay Training Course
March 28-30, 2017
Vancouver, Canada

NEW Standardization of the Hematopoietic Progenitor Assay Training Course
March 28-29, 2017
Vancouver, Canada

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Regulation of Hematopoietic Stem Cells by Niche Cells (Universitätsklinikum Carl Gustav Carus Dresden)

NEW Full Member Faculty – Hematopoietic Cell Transplant Program (Fred Hutchinson Cancer Research Center)

NEW Instructor – Molecular and Cellular Pathology (The University of Alabama)

Research Fellow – Neurobiology (Biomedical Institute for Global Healthcare Research & Technology)

Postdoctoral Research Fellow – Gastrointestinal Research (Boston Children’s Hospital; Harvard Medical School)

Postdoctoral Position – Mesenchymal Stem Cells (University of Southern California)

Principle Scientist – Translational Development (Celgene Corporation)

Postdoctoral Researcher – Epigenetics/Systems Biology (National Heart, Lung and Blood Institute, National Institutes of Health)

Assistant Associate or Full Member Faculty Position – Myeloid Malignancies (Fred Hutchinson Cancer Research Center)

Assistant Member Faculty – Platinum/Immunotherapy (Fred Hutchinson Cancer Research Center)

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