Cord Blood News Volume 9.04 | Feb 2 2017

TOP STORY

The Effect of Inter-Unit HLA Matching in Double Umbilical Cord Blood Transplantation for Acute Leukemia

Scientists studied the effects of inter-unit HLA-mismatching on the outcomes 449 patients with acute leukemia after double cord blood transplantation. [Haematologica] Full Article

(Ranked by impact factor of the journal)

Cord Blood Cell-Derived iPSCs as a New Candidate for Chondrogenic Differentiation and Cartilage Regeneration

Investigators generated human induced pluripotent stem cells (hiPSCs) from cord blood mononuclear cells (CBMCs) using the Sendai virus. Reprogramming was successfully done using CBMCs. CBMC-hiPSCs showed high pluripotency and normal karyotype. [Stem Cell Res Ther] Full Article

Human Umbilical Cord-Derived Mesenchymal Stromal Cells Protect against Premature Renal Senescence Resulting from Oxidative Stress in Rats with Acute Kidney Injury

Researchers aimed to determine whether acute kidney injury leads to premature, stress-induced senescence, as well as whether human umbilical cord-derived mesenchymal stromal cells can prevent ischemia/reperfusion injury-induced renal senescence in rats. [Stem Cell Res Ther] Full Article

Construction of Bioengineered Hepatic Tissue Derived from Human Umbilical Cord Mesenchymal Stem Cells via Aggregation Culture in Porcine Decellularized Liver Scaffolds

The authors established a method that combines the use of decellularized liver scaffolds and aggregation culture of mesenchymal stem cells and explored the effects of the two on hepatic differentiation of human umbilical cord mesenchymal stem cells in bioengineered hepatic tissue. [Xenotransplantation] Abstract

Lymphocyte Expansion after Unrelated Cord Blood Allogeneic Stem Cell Transplantation in Adults

Large granular lymphocytes (LGL) expansions have been reported after bone marrow or peripheral blood, but not after unrelated cord blood (UCB) allogeneic hematopoietic stem cell transplantation (allo-HSCT), associated with indolent clinical courses and favorable outcomes. Scientists considered 85 recipients of UCB allo-HSCT to more broadly define the impact of lymphocytosis, not limited to LGL. Sustained lymphocytosis was observed in 21 patients at a median onset of 12.6 months and with a median duration of 12 months. [Bone Marrow Transplant] Abstract

Comparison of Gingival and Umbilical Cord Stem Cells Based on its Modulus and Neuronal Differentiation

Researchers compared human gingival mesenchymal stem cells (MSCs) with human umbilical cord-derived mesenchymal stem cells and demonstrated that MSCs derived from gingiva have higher proliferation rate and higher population doubling time than umbilical cord. [J Cell Biochem] Abstract

Evidence for the In Vivo Safety of Insulated Foamy Viral Vectors

Investigators evaluated two newly identified human insulators, A1 and A2, for use in foamy viral (FV) vectors. These insulators had moderate insulating capacity and higher titers than previously developed insulated FV vectors. The A1-insulated FV vector was chosen for comparison with the previously described 650cHS4-insulated FV vector in human cord blood CD34⁺ repopulating cells in an immunodeficient mouse model. [Gene Ther] Abstract

Human Cord Blood and Bone Marrow CD34⁺ Cells Generate Macrophages that Support Erythroid Islands

Researchers compared the physical, cellular and molecular interaction between the macrophages and erythroid cells in cell growth switch expanded CD34⁺ cells harvested from cord blood, marrow or G-CSF-mobilized peripheral blood. Results indicated that macrophage based erythroid islands could be generated from cord blood and marrow CD34⁺ cells but not from G-CSF-mobilized CD34⁺ cells. [PLoS One] Full Article

Molecular Effect of Human Umbilical Cord Blood CD34-Positive and CD34-Negative Stem Cells and Their Conjugate in Azoospermic Mice

Scientists aimed to investigate the effect of umbilical cord blood-derived stem cells and mono-cell layer implanted into the induced azoospermic mice testis. [Mol Cell Biochem] Abstract

Explant Culture: An Advantageous Method for Isolation of Mesenchymal Stem Cells from Human Tissues

The author discusses advantages of omitting proteolysis step in isolation process and presence of tissue pieces in primary culture of mesenchymal stem cells (MSCs). They provide an overall report of technical highlights and molecular events of explant culture method for isolation of MSCs from human tissues including adipose tissue, bone marrow, dental pulp, hair follicle, cornea, umbilical cord and placenta. [Cell Prolif] Abstract

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Americord Launches Cord Blood Topic Center

Americord announces the launch of its Cord Blood Topic Center. Americord has created a library of articles on a range of relevant topics, from pregnancy tips and birth planning to stem cell science and clinical trials. [Americord (Business Wire, Inc.)] Press Release

BrainStorm Announces Validation of NurOwn^® Cryopreservation Process

BrainStorm Cell Therapeutics Inc. announced that it has validated its cryopreservation process for NurOwn^® in preparation for the upcoming Phase III clinical study in Amyotrophic Lateral Sclerosis. The validation involved a comparison of NurOwn^® derived from fresh mesenchymal stem cells (MSC) to those derived from cryopreserved MSC. [BrainStorm Cell Therapeutics Inc.] Press Release

Trump Immigration Ban Upends International Work on Disease

Efforts to combat diseases rely on networks of scientists to detect outbreaks early, understand how the diseases operate and then intervene. Researchers say that President Donald Trump’s travel ban challenges that process, putting the United States at risk. [Nature News] Editorial

On 22 April, Empiricists Around the Country Will March for Science

The grassroots team coordinating the March for Science on Washington, D.C., have now set a date: 22 April. And they are inviting organizers in cities around the world to lead parallel demonstrations. [ScienceInsider] Editorial

NEW Applications of the Hematopoietic Progenitor Assay Training Course
March 28-30, 2017
Vancouver, Canada

NEW Metabolism in Time and Space: Emerging Links to Cellular and Developmental Programs
May 11-13, 2017
Heidelberg, Germany

NEW Cord Blood World Europe 2017
May 17-18, 2017
London, United Kingdom

Visit our events page to see a complete list of events in the community.

NEW Assistant/Associate Professor – Allogeneic Stem Cell Transplantation and/or Gene Therapy (Dana Farber/Boston Children’s Cancer and Blood Disorders Center)

Research Associate – Acute Myeloid Leukemia Research (University of Virginia)

Research Group Leader – Leukemia Research (University Hospital Basel)

Scientist Position – Immunology (New York Blood Center)

Full Member Faculty – Hematopoietic Cell Transplant Program (Fred Hutchinson Cancer Research Center)

Instructor – Molecular and Cellular Pathology (The University of Alabama)

Postdoctoral Research Fellow – Gastrointestinal Research (Boston Children’s Hospital; Harvard Medical School)

Principle Scientist – Translational Development (Celgene Corporation)

Assistant Associate or Full Member Faculty Position – Myeloid Malignancies (Fred Hutchinson Cancer Research Center)

Assistant Member Faculty – Platinum/Immunotherapy (Fred Hutchinson Cancer Research Center)

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