Cord Blood News 9.13 April 6, 2017 | |
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TOP STORYRegulation of Cell Surface CB2 Receptor during Human B Cell Activation and Differentiation To better understand the pattern of cannabinoid receptor type 2 (CB2) expression by human B cells, scientists examined CD20+ B cells from three tissue sources. Both surface and intracellular expression were present and uniform in cord blood B cells, where all cells exhibited a naïve mature phenotype. In vitro activation of human cord blood resulted in a down-regulation of surface CB2 on those B cells acquiring the activated phenotype but not on those retaining IgD expression. [J Neuroimmune Pharmacol] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators describe the generation of transgene-free human induced pluripotent stem cells (hiPSC) from cord blood derived CD34+ cells, reprogrammed using CytoTuneâ„¢ Sendai reprogramming vectors. CD34+ cell isolation, cultivation, reprogramming and establishment of resulting hiPSC lines were performed under the exclusive usage of animal-derived component-free materials and components. [Stem Cell Res] Full Article Peri-engraftment bone marrow (BM) specimens of 32 adult patients with normal engraftment, delayed engraftment or graft failure were retrospectively evaluated to identify the potential associations of CD163+ macrophage and CD8+ lymphocyte infiltration into BM. [Bone Marrow Transplant] Abstract The authors retrospectively analyzed incidence and risk factors for the development of therapy-related acute myeloid leukemia and myelodysplastic syndrome in lymphoma patients treated with autologous or allogeneic hematopoietic cell transplantation. [Bone Marrow Transplant] Abstract Scientists analyzed the epigenetic environment in terms of histone modifications in cultures of mesenchymal stem cells derived from amniotic fluid of normal pregnancies and those with fetal abnormalities. Cell populations from normal pregnancies and proliferation potential I samples had similar growth characteristics and exhibited a quite similar cell surface and stemness markers profile that was distinct in slower growing and faster senescent proliferation potential II cultures. [J Cell Biochem] Abstract Investigators evaluated the impact of widely used FDA approved poly(α-esters) including polylactide and polycaprolactone on selected biological properties of mesenchymal stem cells harvested from human umbilical cord Wharton’s jelly (hUC-MSCs) in vitro. They found that both polymers can be used as non-toxic substrates for ex vivo propagation of hUC-MSCs as shown by no major impact on cell proliferation or viability. [Mater Sci Eng C Mater Biol Appl] Abstract Researchers found that the appearance of cluster forming cells in cultures from myelomeningocele (MMC)-amniotic fluid (AF) correlated with activation of astrogliosis associated with the spinal cord injury in MMC fetuses. They identified a neuroepithelial cell population in the AF of MMC fetuses that formed adherent clusters in culture and they characterized cellular markers of these cells. [PLoS One] Full Article Evaluating the Efficacy of Different Types of Stem Cells in Preserving Gut Barrier Function in NEC Scientists investigated the efficacy of four different types of stem cells (SC) in preservation of gut barrier function during necrotizing enterocolitis (NEC). They compared: amniotic fluid-derived mesenchymal SC; bone marrow-derived MSC; amniotic fluid-derived neural SC; and enteric NSC. Rat pups exposed to NEC but treated with SC had significantly reduced intestinal permeability. [J Surg Res] Abstract | |
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REVIEWSAdvances in Umbilical Cord Blood Cell Therapy: The Present and the Future The authors cover the advances in umbilical cord blood (UCB) transplantation to overcome the limitation regarding cellular dose, immunological naivety and additional cell doses such as DLI. They also provide an overview regarding the progress in adoptive cellular therapy using UCB. [Expert Opin Biol Ther] Abstract Investigators summarize current knowledge on the differentiation of human amnion: epithelial cells into liver cells and their potential therapeutic application. [Placenta] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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SCIENCE NEWSThe Use of MiMedx Allografts from the Company’s Multiple Product Families to Be Presented MiMedx Group, Inc. will present the clinical and cost effective healing results of the company’s dehydrated human amnion/chorion membrane allografts. [Press release from MiMedx Group, Inc. discussing research to be presented at the 2017 Symposium on Advances in Wound Care Spring and Wound Healing Society (SAWC Spring/WHS), San Diego] Press Release | |
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INDUSTRY NEWSAbbVie announced a supplemental New Drug Application was accepted for review by the U.S. Food and Drug Administration (FDA) for ibrutinib in cGvHD after failure of one or more lines of systemic therapy. [AbbVie Inc.] Press Release The Leukemia & Lymphoma Society continues to advance the promising field of immunotherapy research, harnessing the body’s own immune system to fight cancer, with a $4 million funding commitment in an investigational therapy being developed by Forty Seven Inc. for lymphoma patients. The novel drug will be tested in combination with the FDA-approved rituximab, already part of standard treatment for several types of non-Hodgkin lymphoma. [The Leukemia & Lymphoma Society (PR Newswire Association LLC.)] Press Release | |
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POLICY NEWSJapanese Scientists Call for Boycott of Military Research The Science Council of Japan, an advisory body to the cabinet, representing some 850,000 Japanese scientists, released a statement calling on scientists to boycott military research and for universities and research organizations to evaluate the threats posed by such work. [Nature News] Editorial Initiative Aims to Break Science’s Citation Paywall The Initiative for Open Citations (I4OC) aims to allow anyone to access science papers’ reference lists and to build analytical services on top of that raw data. Started by the Wikimedia Foundation in San Francisco, California and five other partner organizations, I4OC announced at its official launch that 29 organizations, including some of the world’s largest scientific publishers, have now agreed to openly release citation data. [Nature News] Editorial
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EVENTSNEW International Conference on Malignant Lymphoma (ICML) Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Full Professor – Stem Cell Transplantation (Dana-Farber/Boston Children’s Hospital) Postdoctoral Fellow – Cancer Research (German Cancer Research Center) Postdoctoral Fellow – Stem Cell Research (Helmholtz Association) Postdoctoral Fellow – Leukemia Research (Children’s Hospital Los Angeles) Assistant and Associate Professors – Regenerative & Cancer Cell Biology (Albany Medical College) Staff Scientist/Assistant Professor – Nonmalignant Hematology (New York Blood Center) Research Group Leader – Leukemia Research (University Hospital Basel) Principle Scientist – Translational Development (Celgene Corporation) Full Member Faculty – Hematopoietic Cell Transplant Program (Fred Hutchinson Cancer Research Center) Assistant Member Faculty – Platinum/Immunotherapy (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Cord Blood News Volume 9.13 | Apr 6 2017