Cord Blood News 9.15 April 20, 2017 | |
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TOP STORYStudy Shows Protein in Human Umbilical Cord Blood Rejuvenates Old Mice’s Impaired Learning, Memory Human umbilical cord blood can rejuvenate learning and memory in older mice, according to researchers. They identified a protein, abundant in human cord blood but decreasingly so with advancing age, that had the same effect when injected into the animals. The findings could lead to new treatments for age-associated declines in mental ability. [Press release from the Stanford University School of Medicine discussing online prepublication in Nature] Press Release | Abstract | Editorial | |
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PUBLICATIONS(Ranked by impact factor of the journal)EPCR Expression Marks UM171-Expanded CD34+ Cord Blood Stem Cells Scientists showed that endothelial protein C receptor (EPCR)-positive UM171-treated cells, as opposed to EPCR-negative cells, exhibit robust multi-lineage repopulation and serial reconstitution ability in immunocompromised mice. In contrast to other stem cell markers such as CD38, EPCR expression was maintained when cells are introduced in culture, irrespective of UM171 treatment. [Blood] Abstract Scientists investigated whether endothelial colony forming cells (ECFC) and mesenchymal progenitor cells (MPC) form vascular networks and restore blood flow in ischemic skeletal muscle, and whether host myeloid cells play a role. Hind limbs injected with ECFC + MPC showed greater blood flow recovery compared with ECFC, MPC, or vehicle. [Sci Rep] Full Article Researchers investigated the effect of a scaffold/umbilical cord-derived mesenchymal stem cells (UC-MSCs) construct on collagen degradation and functional regeneration in rat uterine scars following full-thickness excision of uterine walls. PBS, degradable collagen fibres, UC-MSCs or UC-MSCs mixed with gelatinous degradable collagen fibres were injected into four pre-marked points surrounding each uterine scar, respectively. The scaffold/UC-MSCs-treated uterine scars showed nearly complete restoration of receptive fertility. [Stem Cell Res Ther] Full Article The authors studied the feasibility of radiation dose escalation in high risk patients using total marrow irradiation (TMI) in a Phase I dose-escalation trial. They showed that dose escalation of TMI to 15 Gy is feasible with acceptable toxicity in pediatric and adult high risk leukemia patients undergoing umbilical cord blood and sibling donor transplantation. [Biol Blood Marrow Transplant] Abstract Scientists demonstrated long-term persistence of human mesenchymal stromal cells (hMSCs) after intracoronary injection in a large animal model of pulmonary hypertension. hMSCs injected via intracoronary infusion survived up to 24 days and demonstrated proliferative capacity. [Cytotherapy] Abstract | |
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REVIEWSFetal and Perinatal Stem Cells in Cardiac Regeneration: Moving Forward to the Paracrine Era The authors discuss the paracrine potential of the fetal and perinatal stem cell secretome to provide cardiac repair and resurge the dormant mechanisms of cardiac regeneration for future therapy. [Placenta] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSClinician-Researcher to Lead New Bone Marrow Transplantation Initiative Hematologist-oncologist Ahmad Samer Al-Homsi, MD, MBA, will lead a new bone marrow transplantation program at NYU Langone’s Perlmutter Cancer Center for treating blood-borne cancers, including leukemia, lymphoma, and multiple myeloma, and potentially utilize transplantation as an adjunct to immunotherapy for solid tumors. [NYU Hospitals Center] Press Release Mediware® and Therigy® Announce New Partnership to Enable the Delivery of Value-Based Outcomes Mediware Information Systems, Inc. and Therigy unveiled a new partnership and integration between Mediware’s CareTend software and TherigySTM™ to automate, standardize, and scale patient management, and enable the delivery of value-based outcomes. [Mediware Information Systems, Inc.] Press Release Plasticell and Kings College London to Collaborate in Trials of Blood Platelet Substitute Plasticell announced it has partnered with Kings College London to progress preclinical trials of its artificial blood platelet product, manufactured from pluripotent stem cells. [Plasticell] Press Release | |
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POLICY NEWSWhat a Surprise General Election Could Mean for HE Theresa May’s plan to hold a general election on the 8th of June raises implications for universities in terms of whether the Higher Education and Research Bill can continue, the vote’s status as the “Brexit election”, and the expected emergence of Labor’s plan to scrap tuition fees. [Times Higher Education] Editorial Republican Scientists Negotiate the Trump Era Conservative academics face a growing tension between their politics and the liberal atmosphere on many US campuses. [Nature News] Editorial French-Election Fears Unite Scientists in Defense of Liberal Democracy For scientists in France, the presidential contest is often a chance to debate research and science-related issues. When Nicolas Sarkozy was elected a decade ago, for example, university reforms and environmental policy featured prominently in the campaigns. But this time, science has barely been mentioned — elbowed out by political scandals and the rise of Marine Le Pen’s far-right Front National party. [Nature News] Editorial
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EVENTSNEW Hematologic Malignancies Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Leukemia Research (VIB-KU Leuven Center) Postdoctoral Position – Regulation of HSCs by Niche Cells (Technical University Dresden) Full Professor – Stem Cell Transplantation (Dana-Farber/Boston Children’s Hospital) Postdoctoral Fellow – Cancer Research (German Cancer Research Center) Postdoctoral Fellow – Stem Cell Research (Helmholtz Association) Postdoctoral Fellow – Leukemia Research (Children’s Hospital Los Angeles) Research Group Leader – Leukemia Research (University Hospital Basel) Full Member Faculty – Hematopoietic Cell Transplant Program (Fred Hutchinson Cancer Research Center) Assistant Member Faculty – Platinum/Immunotherapy (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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