Cord Blood News Volume 9.25 | Jun 29 2017

TOP STORY

HLA-DPB1 Mismatch Induces a Graft-versus-Leukemia (GvL) Effect without Severe Acute GvHD after Single-Unit Umbilical Cord Blood Transplantation

The authors studied the impact of HLA-DPB1 mismatch, along with the effect of other HLA-loci mismatches at the allele level. HLA six loci alleles were retrospectively typed in 1157 Japanese donors and patients with leukemia or myelodysplastic syndrome who underwent transplantation with a single unit of cord blood. [Leukemia] Abstract

(Ranked by impact factor of the journal)

Nuclear Factor Erythroid 2 Regulates Human HSC Self-Renewal and T Cell Differentiation by Preventing NOTCH1 Activation

Scientists investigated the role of nuclear factor erythroid-derived 2 (NF-E2) in normal human hematopoiesis. Knockdown of NF-E2 in the hematopoietic stem and progenitor cells not only reduced the formation of megakaryocytes but also drastically impaired hematopoietic stem cell activity, decreasing human engraftment in immunodeficient mice. [Stem Cell Reports] Full Article

Single- or Double-Unit UCBT Following RIC in Adults with AL: A Report from Eurocord, the ALWP and the CTIWP of the EBMT

Researchers compared cord blood transplantation (CBT) outcomes in patients given single or double CBT following reduced-intensity conditioning (RIC) in a retrospective multicenter registry-based study. In univariate analysis, in comparison to patients transplanted with a single CB, double CB recipients had a similar incidence of neutrophil engraftment but a suggestion for a higher incidence of grade II–IV acute GVHD. [J Hematol Oncol] Full Article

Surface Expression of Anti-CD3scfv Stimulates Locoregional Immunotherapy against Hepatocellular Carcinoma Depending on the E1A-Engineered Human Umbilical Cord Mesenchymal Stem Cells

The authors designed a strategy to modify hepatocellular carcinoma (HCC) cells by surface expressing anti-CD3scfv within the tumor site strictly, which depended on the E1A-engineered human umbilical cord mesenchymal stem cells delivery system. Subsequently, membrane-bound anti-CD3scfv actived the lymphocytes which lysed HCC cells bypassing the expression of antigens or MHC restriction. [Int J Cancer] Abstract

Human In Vitro-Induced Regulatory T Cells Display Dlgh1-Dependent and PKC-θ Restrained Suppressive Activity

Investigators report that human induced human regulatory T cells generated in vitro from naïve cord blood cells preferentially recruit Disc large homolog 1 (Dlgh1) and exclude protein kinase C-θ from immunological synapses formed on supported lipid bilayers with laterally mobile ICAM-1 and anti-CD3 mAb. [Sci Rep] Full Article

Mesenchymal Stem Cells Secretome-Induced Axonal Outgrowth Is Mediated by BDNF

Scientists demonstrated that application of MSCs secretome to both rat cortical and hippocampal neurons induces an increase in axonal length. In addition, they showed that this growth effect is axonal intrinsic with no contribution from the cell body. [Sci Rep] Full Article

Polycaprolactone Nanofiber Scaffold Enhances the Osteogenic Differentiation Potency of Various Human Tissue-Derived Mesenchymal Stem Cells

Researchers illustrated that human umbilical cord-, bone marrow-, and adipose tissue-derived MSCs exhibited fibroblast-like morphology and expressed characteristic markers. Polycaprolactone nanofiber scaffold could support those MSC adhesion and proliferation. [Stem Cell Res Ther] Full Article

Human Umbilical Cord Stem Cell Conditioned Medium versus Serum-Free Culture Medium in the Treatment of Cryopreserved Human Ovarian Tissues in In–Vitro Culture: A Randomized Controlled Trial

Investigators aimed to determine whether human umbilical cord stem cell-conditioned medium (HUMSC-CM) improves the development of frozen-thawed in–vitro cultured ovarian tissues compared with a serum-free culture medium (SF-CM). A significant difference in the rate of morphologically normal primordial follicles in the HUMSC-CM group was observed compared to that in the serum-free culture medium group from days two to four. [Stem Cell Res Ther] Full Article

Durable Chimerism and Long-Term Survival following Unrelated Umbilical Cord Blood Transplantation for Pediatric Hemophagocytic Lymphohistiocytosis: A Single Center Experience

Unrelated umbilical cord blood transplantation (UCBT) provides a readily available alternative donor source for patients lacking matched related donors. Scientists report the results of UCBT in 14 children treated between 1998 and 2016. [Biol Blood Marrow Transplant] Abstract

Phase II Study of Intrabone Single Unit Cord Blood Transplantation for Hematological Malignancies

In this Phase II study, 21 adult patients with hematological malignancy received intrabone transplantation of serological HLA-A, B, and DR ≥4/6 matched single cord blood with a median number of cryopreserved total nucleated cells of 2.7 × 10⁷/kg following non-irradiated fludarabine-based reduced-intensity conditioning. [Cancer Sci] Full Article

Clinical Impact of NK-Cell Reconstitution after Reduced Intensity Conditioned Unrelated Cord Blood Transplantation in Patients with Acute Myeloid Leukemia: Analysis of a Prospective Phase II Multicenter Trial on Behalf of the Société Française De Greffe De Moelle Osseuse Et Thérapie Cellulaire and Eurocord

Scientists studied the reconstitution of natural killer (NK) cells and KIR-L mismatch in 54 patients who underwent a reduced intensity conditioning (RIC)-unrelated cord blood transplantation (UCBT) for acute myeloid leukemia in CR in a prospective Phase II clinical trial. After RIC-UCBT, NK cells displayed phenotypic features of both activation and immaturity. [Bone Marrow Transplant] Abstract

Concise Review: Amniotic Fluid Stem Cells: The Known, the Unknown, and Potential Regenerative Medicine Applications

Although significant questions remain regarding the origin, heterogeneous phenotype, and expansion potential of amniotic fluid stem cells, evidence to date supports their potential role as a valuable stem cell source for the field of regenerative medicine. [Stem Cells] Full Article

Visit our reviews page to see a complete list of reviews in the cord blood research field.

BloodCenter of Wisconsin Launches Hematology Genetics Test Panels

BloodCenter of Wisconsin’s Diagnostic Laboratories announced the launch of seven hematology genetics test panels. The new test panels enhance and expand BloodCenter’s genetic testing capability to include a vast array of non-malignant hematology disorders, including platelet function disorders, inherited thrombocytopenia and congenital neutropenias, providing one of the most comprehensive test menus in hematology. [BloodCenter of Wisconsin] Press Release | Video

Cell Medica Acquires WT1 Cancer Immunotherapy from Cell and Gene Therapy Catapult

Cell Medica announced the acquisition of Catapult Therapy TCR Limited and the initiation of a collaboration to establish cell therapy manufacturing for Cell Medica at CGT Catapult’s GMP manufacturing facility in Stevenage, UK. [Cell Medica] Press Release

Canada’s Basic Science at Risk of Fading Away, Report Argues

Canada’s scientific enterprise is at risk of sinking to junk bond status as a result of a funding crunch and misguided government and granting council policies, argues a report. In particular, the authors decry a steady shift away from basic science that has left a smaller portion of the nation’s growing scientific community focused on fundamental research. [ScienceInsider] Editorial

Putin Tightens Control over Russian Academy of Sciences

The Russian government has taken further steps to tighten its grip on the Russian Academy of Sciences (RAS) in Moscow. The State Duma—one of the two chambers of the Russian parliament—passed the first draft of a new law that would give president Vladimir Putin the final say in the elections for RAS’s presidency. [ScienceInsider] Editorial

NEW 11^th World Congress for Microcirculation
September 9-13, 2018
Vancouver, British Columbia, Canada

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow Position – Lymphoid Progenitors from Hematopoietic Stem Cells (Stanford University/Weinberg Laboratory)

NEW Junior Group Leader Position – Leukemia (Philipps-Universität Marburg)

Postdoctoral Research Fellow – Leukemia (Fred Hutchinson Cancer Research Center)

Collector – Cord Blood (Anthony Nolan)

Lab Assistant – Cord Blood and/or Cord Tissue Stem Cell Banking (Cryo-Cell International, Inc.)

Postdoctoral Fellow – Prenatally Transplanted Stem Cells (Northwestern University Medical)

Postdoctoral Research Fellow – Sleeping Beauty (Moffitt Cancer Center)

Postdoctoral Research Position – Lymphoma (Memorial Sloan Kettering Cancer Center)

Postdoctoral Position – Acute Myeloid Leukemia (LMU Munich)

Assistant Associate or Full Member Faculty Position – Myeloid Malignancies (Fred Hutchinson Cancer Research Center)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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