Cord Blood News 9.35 September 7, 2017 | |
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TOP STORYResearchers examined whether administering extracts of mesenchymal stem cells (MSCs) instead of MSCs could augment the beneficial effects of MSC therapy by overcoming the low homing efficiency of MSCs systemically administered in inflammatory bowel diseases. [Sci Rep] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)The Stem Cell Regulator PEDF Is Dispensable for Maintenance and Function of Hematopoietic Stem Cells When human cord blood stem and progenitor cells were cultured in media supplemented with recombinant pigment epithelium derived factor (PEDF) they did not show changes in growth potential. [Sci Rep] Full Article Scientists investigated the neuroprotective effects of human placenta derived mesenchymal stem cells using an established optic nerve compression model, and model of R28 cells that were exposed to hypoxia. [J Tissue Eng Regen Med] Abstract Researchers collected amniotic fluid at term using a novel collection system and evaluated amniotic fluid mesenchymal stromal cell content and their characteristics, including their feasibility to undergo cellular reprogramming. [Stem Cell Res Ther] Full Article Investigators compared the utility of human mesenchymal stem/stromal cells (MSCs) isolated from fetal term placenta and fetal first trimester bone marrow in a polycaprolactone scaffold/BMP7-based model in nude mice. [Biotechnol J] Abstract The authors investigated the efficacy and safety of umbilical cord mesenchymal stem cells (UC-MSCs) for the treatment of Crohn’s disease. Forty-one patients were randomly selected to receive a total of four peripheral intravenous infusions. [Gut Liver] Abstract Direct Conversion of Human Umbilical Cord Blood into Induced Neural Stem Cells with SOX2 and HMGA2 Scientists describe a detailed method for the generation of induced neural stem cells derived from human umbilical cord blood using the lineage-specific transcription factors SOX2 and HMGA2. [Int J Stem Cells] Abstract Investigators employed a simple and economically efficient protocol to isolate mesenchymal stem cells from human umbilical cord tissues without using digestive enzymes and replacing fetal bovine serum with umbilical cord blood serum. [Int J Stem Cells] Abstract | |
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REVIEWSCritical View on Mesenchymal Stromal Cells in Regenerative Medicine Researchers critically discuss clinical mesenchymal stem cell applications. They conclude that adherence to rigorous methodological rules is necessary to prevent the procedures which can be dangerous for patients and scientific research on the medical use of stem cells. [Antioxid Redox Signal] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWS$8.7 Million Awarded to Support Phase III Femoral Neck Fracture Trial by EU Horizon 2020 Program Pluristem Therapeutics Inc. announced that its Phase III study of PLX-PAD cells to support recovery following surgery for femoral neck fracture has been awarded an $8.7 million non-dilutive grant from the Horizon 2020 program, the European Union’s largest research and innovation program. [Pluristem Therapeutics Inc.] Press Release CSL Behring to Acquire Biotech Company Calimmune and Its Proprietary Stem Cell Gene Therapy Platform CSL Behring announced that it has agreed to acquire Calimmune, Inc., a biotechnology company focused on the development of ex vivo hematopoietic stem cell gene therapy with R&D facilities in Pasadena, California and Sydney, Australia for an upfront payment of $91 million. [CSL Behring (PR Newswire Association LLC.)] Press Release | |
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POLICY NEWSUnited Kingdom Wants Cozy Science Ties with Europe after Brexit The U.K. government released a long-awaited position paper on the future of scientific collaborations with the European Union after Brexit. Its overarching goal is “a more ambitious and close partnership with the EU than any yet agreed between the EU and a non-EU country.” [ScienceInsider] Editorial Senate Spending Panel Approves $2 Billion Raise for NIH in 2018 A Senate subcommittee approved a $2 billion raise, to $36.1 billion, for the National Institutes of Health (NIH) in the 2018 fiscal year. To the relief of research universities, the Senate draft spending bill would also block a Trump proposal to slash NIH payments to cover the overhead costs of research. [ScienceInsider] Editorial Researchers Thought Peace in Colombia Would Mean More Science Funding. They Were Wrong Wearing lab coats and hoisting placards with slogans such as “A country without science is a country without a future,” hundreds of scientists poured into plazas in cities across Colombia. Their beef: a proposed 42% cut to the 2018 budget of Colciencias, the nation’s science ministry in Bogotá, which doles out research grants and supports graduate students. [ScienceInsider] Editorial
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EVENTSNEW 2018 Blood and Marrow Transplantation (BMT) Tandem Meetings Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESTechnical Director – Personalized Stem Cell Banking (Brilliant Research) Director – Allogenic Hematopoietic Stem Cell Transplantation (Princess Margaret Cancer Centre) Postdoctoral Scholar – Malignant Hematopoiesis (Penn State College of Medicine) Assistant Professor – Stem Cell and Regenerative Biology (Harvard University) Postdoctoral Position – Cell Biology (The Scripps Research Institute) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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