Cord Blood News 9.37 September 21, 2017 | |
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TOP STORYResearchers showed that shRNA-mediated depletion of the m6A-forming enzyme METTL3 in human hematopoietic stem/progenitor cells promotes cell differentiation, coupled with reduced cell proliferation. Conversely, overexpression of wild-type METTL3, but not of a catalytically inactive form of METTL3, inhibited cell differentiation and increases cell growth. [Nat Med] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)The authors investigated the global immune-related gene expression profiles of human embryonic stem cells, human induced pluripotent stem cells and somatic cells and identified candidate immune-related genes that may alter their immunogenicity. They found that the inhibition of mammalian target of rapamycin complex signal pathways significantly downregulated the immunogenicity of differentiated stem cells. [Exp Mol Med] Full Article Scientists examined the adoptive transfer of ex vivo expanded human cord blood-derived natural killer (NK) cells into humanized mice reconstituted with autologous human cord blood immune cells. They report that ex vivo expanded NK cells were able to survive and possibly proliferate in vivo in humanized mice without exogenous cytokine administration, but not in control mice that lack human immune cells. [Sci Rep] Full Article Since human umbilical cord Wharton’s jelly stem cells (hWJSCs) possess immunomodulatory properties, researchers investigated whether one of the tumoricidal mechanisms was via immunogenic cell death. They concentrated hWJSC-conditioned medium into a 3 kDa concentrate and then exposed various concentrations of this concentrate to human lymphoma cells to find out which concentration had the greatest tumoricidal effect. [Stem Cell Rev] Abstract The authors determined the protective effects of Nrf2-transfected human amniotic MSCs (hAMSCs) against lipopolysaccharide (LPS)-induced lung injury in mice. They found that, compared with control hAMSCs, treatment with Nrf2-overexpressing hAMSCs led to further reduced lung injury, lung fibrosis, and inflammation in LPS-challenged mice. [J Cell Biochem] Abstract Engineering Human Cell Spheroids to Model Embryonic Tissue Fusion In Vitro Investigators developed a three-dimensional culture system that mimics the embryonic palate and could be used to study fusion behavior in vitro using human cells. They engineered size-controlled human Wharton’s Jelly stromal cell spheroids and established that seven days of culture in osteogenesis differentiation medium was sufficient to promote an osteogenic phenotype consistent with embryonic palatal mesenchyme. [PLoS One] Full Article Scientists investigated the roles of exosomes that are derived from USC-CM in cutaneous collagen synthesis and permeation. They found that USC-CM has various growth factors associated with skin rejuvenation. [Biochem Biophys Res Commun] Abstract | |
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REVIEWSHuman Umbilical Cord Blood Cell Transplantation in Neuroregenerative Strategies The authors consider the key characteristics of human umbilical cord blood (hUCB), the results of various studies focused on the treatment of neurodegenerative diseases, ischemic and traumatic injuries of the nervous system, and the molecular mechanisms of hUCB-derived mononuclear and stem cells. [Front Pharmacol] Full Article Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSFormula Pharmaceuticals, Inc. announced the opening of the first clinical trial for allogeneic cytokine induced killer (CIK) cell-based chimeric antigen receptor (CAR) cancer immunotherapy. [Formula Pharmaceuticals, Inc.] Press Release TissueTech Inc. announced that it has been awarded four patents by the U.S. Patent Trademark Office. Two of the patents cover methods of promoting bone formation and the others cover methods for lyophilizing and sterilizing placental tissue. [TissueTech Inc.] Press Release | |
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POLICY NEWSPublishers Go After Networking Site for Illicit Sharing of Journal Papers A major scientific publishing group is taking aim at a social networking site for allowing researchers to illegally post copies of their journal papers. The International Association of Scientific, Technical, and Medical Publishers in Oxford, U.K., and The Hague, the Netherlands, has written to ResearchGate, a networking website for researchers, to express concerns over its article-sharing practices. [ScienceInsider] Editorial United Kingdom Sees Dip in European Research Applications after Brexit Vote The number of researchers applying for Europe-funded Marie Curie fellowships in the United Kingdom has dipped slightly since the country’s vote to leave the European Union, data released to Nature show. But there is no evidence yet of a sharp collapse in interest, which some scientists had feared in the wake of the Brexit referendum. [Nature News] Editorial A Far-Right Party Is about to Enter the German Parliament. What Does that Mean for Science? Angela Merkel will likely remain chancellor after the German elections, but the voting will shake up German federal politics in another way. Polls predict that the far-right Alternative for Germany will get close to 10% of the vote, winning seats in the federal legislature, the Bundestag, for the first time. [ScienceInsider] Editorial HHMI’s Own Brand of Diversity in the Life Sciences One of Erin O’Shea’s first moves as Howard Hughes Medical Institute (HHMI) president was committing $25 million a year to support postdocs from underrepresented groups. Her hope was that they would eventually change the color—and culture—of their departments as they moved into leadership positions, in addition to serving as role models for the next generation of scientists. [ScienceInsider] Editorial
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EVENTSNEW 7th in Leukemia Research (NDLR) Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Acute Myeloid Leukemia (University Hospital of Ulm) Postdoctoral Associate – Biomedical and Single-Cell Genomics (Cornell University) Technical Director – Personalized Stem Cell Banking (Brilliant Research) Director – Allogenic Hematopoietic Stem Cell Transplantation (Princess Margaret Cancer Centre) Postdoctoral Scholar – Malignant Hematopoiesis (Penn State College of Medicine) Assistant Professor – Stem Cell and Regenerative Biology (Harvard University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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