Cord Blood News Volume 9.45 | Nov 16 2017

TOP STORY

Thermosensitive, Stretchable, and Piezoelectric Substrate for Generation of Myogenic Cell Sheet Fragments from Human Mesenchymal Stem Cells for Skeletal Muscle Regeneration

In a native muscle microenvironment, electrical and mechanical stimuli exist in the form of action potentials and muscle contraction. A cell culture system was developed that can mimic the in vivo microenvironment and provided these stimuli to cultured cells, and it was tested whether the stimulation can promote myogenic differentiation of human umbilical cord blood mesenchymal stem cells. [Adv Funct Mater] Abstract

(Ranked by impact factor of the journal)

KSRP Specifies Monocytic and Granulocytic Differentiation through Regulating miR-129 Biogenesis and RUNX1 Expression

The authors report the global RNA-binding protein transcriptomic analysis of myeloid differentiation by combining RNA-seq analysis with myeloid induction in CD34⁺ hematopoietic progenitor cells. The downregulated expression of the KH-Type Splicing Regulatory Protein (KSRP) during monocytopoiesis and up-regulated expression during granulopoiesis suggests that KSRP has divergent roles during monocytic and granulocytic differentiation. [Nat Commun] Full Article

Neuroprotective Potential and Paracrine Activity of Stromal vs. Culture-Expanded hMSC Derived from Wharton Jelly under Co-Cultured with Hippocampal Organotypic Slices

Scientists determined neuroprotection-linked cell phenotypic and functional changes that could spontaneously take place when freshly isolated Wharton’s jelly MSCs undergo standard selection, growth, and spontaneous differentiation throughout passaging in vitro. [Mol Neurobiol] Full Article

Combined Haploidentical and Umbilical Cord Blood Allogeneic Stem Cell Transplantation for High-Risk Lymphoma and CLL

Researchers analyzed 42 lymphoma and CLL patients who underwent haploidentical grafts with umbilical cord blood (haplo-cord) allogeneic stem cell transplantation. Haplo-cord transplantation offers a transplant alternative for patients with recurrent or refractory lymphoid malignancies who lack matching donors. [Biol Blood Marrow Transplant] Abstract

Amniotic Mesenchymal Stem Cells Mitigate Osteoarthritis Progression in a Synovial Macrophage-Mediated In Vitro Explant Co-Culture Model

An in vitro co-culture model of patient-matched human osteoarthritis (OA) cartilage and synovium was assessed for viability, macrophage phenotype, and progressive cartilage destruction in the presence of an inflammatory milieu. The model was used to compare the ability of human amniotic and adipose stem cells to mitigate OA progression. [J Tissue Eng Regen Med] Abstract

The Feasibility of Intraperitoneal Placenta-Derived Mesenchymal Stem Cell Injection in Stomachs of Diabetic Mice

Investigators aimed to confirm the pathogenetic changes in diabetic gastropathy and examined the effect of treatment with placental derived mesenchymal stem cells (PDMSCs) in stomachs of animal models. Interstitial cell of Cajal and neural plexus decreased in stomachs of mice with diabetes mellitus, but were significantly repaired with intraperitoneal injection of PDMSCs. [J Gastroenterol Hepatol] Abstract

Placenta-Derived PLX-PAD Mesenchymal-Like Stromal Cells Are Efficacious in Rescuing Blood Flow in Hind Limb Ischemia Mouse Model by a Dose- and Site-Dependent Mechanism of Action

The hind limb ischemia (HLI) mouse model was utilized to study the efficacy and mechanism of action of PLX-PAD cells. PLX-PAD cells administered intramuscularly rescued blood flow to the lower limb after HLI induction in a dose-dependent manner. [Cytotherapy] Abstract

Umbilical Cord-Derived Mesenchymal Stem Cells Alleviated Inflammation and Inhibited Apoptosis in Interstitial Cystitis via AKT/mTOR Signaling Pathway

The authors investigated the effects of human umbilical cord-derived MSCs injection on interstitial cystitis (IC) rat model. They used a coculture system to find the possible molecular mechanism on the human uroepithelial cells, which was the cell model of IC. [Biochem Biophys Res Commun] Abstract

Effect of Human Umbilical Cord Blood-Derived Mononuclear Cells on Diabetic Nephropathy in Rats

This study was designed to elucidate the effect of mononuclear cells (MNCs) injection on reverse diabetic nephropathy (DN) in rats exposed to streptozotocin (STZ) injection compared to metformin as a known hypoglycemic drug. The results indicated an improvement effect of MNCs and metformin on STZ-induced DN in rats. [Biomed Pharmacother] Full Article

Mitochondrial Transfer in the Leukemia Microenvironment

The authors discuss the functional roles of mitochondrial transfer between bone marrow microenvironment and leukemic cells, and give insights into a new mechanism of drug resistance whose understanding will open the way to innovative anticancer adjuvant treatments. [Trends Cancer] Abstract

Visit our reviews page to see a complete list of reviews in the cord blood research field.

Golden Meditech and GE Healthcare Team Up to Develop Safe and Efficient Cord Blood Storage Services

Golden Meditech Holdings Limited announced that it has formed a strategic collaboration with GE Healthcare. Pursuant to the collaboration, GE Healthcare will provide an integrated and automated digital system and solutions to the group’s umbilical cord blood cryopreservation processes, aiming to provide efficient storage services to customers at large. [Golden Meditech Holdings Limited] Press Release

LabCorp Receives 2017 Partnership Award from Be The Match^®

LabCorp announced that it received the 2017 Partnership Award from Be The Match^® at the nonprofit’s 30^th Annual Council Meeting in Minneapolis. [Laboratory Corporation of America^® Holdings.] Press Release

HistoGenetics Receives Innovation Award from Be The Match

HistoGenetics announced that it has received the prestigious Innovation Award from Be The Match^®. [HistoGenetics (Business Wire, Inc.)] Press Release

African Scientists Get Their Own Open-Access Publishing Platform

Africa’s academy of science has announced that it will launch an open-access publishing platform — the first of its kind aimed exclusively at scientists on the continent. [Nature News] Editorial

Graduate Students Face Alarming Tax Hike

The last thing that graduate students need is a tax hike. But that is what many would face under a clause in the federal-tax-reform bill passed by the US House of Representatives. It will need to be reconciled with the Senate’s tax-reform bill (which retains many existing student tax benefits), and signed by the president. [Nature News] Editorial

NEW International Society for Stem Cell Research (ISSCR) 2018 Annual Meeting
June 20-23, 2018
Melbourne, Australia

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow – Acute Myeloid Leukemia (St. Louis Hospital)

NEW Staff Scientist – Hematopoiesis (University of Copenhagen)

Senior Customer Success Specialist – Blood & Marrow Transplantation and Cell Therapy (STEMCELL Technologies Inc.)

Scientist – Hematopoietic Stem Cells (Karlsruhe Institute of Technology)

Postdoctoral Positions – Hematopoietic/Leukemic Stem Cell Biology (New York University School of Medicine)

Faculty Positions – Hematological Malignancies (University of Alabama at Birmingham)

Postdoctoral Fellow – Hematology (University of Tennessee Health Science Center)

Postdoctoral Research Fellow – Hematopoietic Stem Cell Development (Cincinnati Children’s Hospital Medical Center)

Postdoctoral Fellowship – Development & Epigenetics (Centre National de la Recherche Scientifique)

Postdoctoral Fellow – Hematopoietic Stem Cells (Memorial Sloan Kettering Cancer Center)

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