Cord Blood News 9.46 November 23, 2017 | |
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TOP STORYEmploying two strategies, scientists generated induced pluripotent stem cell-hepatocyte-like cells (HLCs) and hiHeps from the same donor cell line. Both types of HLCs clustered distinctly from each other during gene expression profiling. [Stem Cell Reports] Full Article | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)In vitro, the authors observed that human cardiac adipose tissue-derived MSCs and umbilical cord MSCs similarly polarize monocytes toward a regulatory M2 phenotype, which maintained the expression of CD39 and induced expression of CD73 in a cell contact dependent fashion, correlating with increased functional activity. [Front Immunol] Full Article Optimized Lentiviral Transduction of Human Amniotic Mesenchymal Stromal Cells Investigators hypothesized that the use of lentiviral vectors containing specific regulatory sequences may result in improved transduction efficiency. They demonstrated that with the pLenti7.3 it is possible to efficiently transduce human mesenchymal stromal cells with a single transduction cycle. [Pharmacol Res] Abstract | Graphical Abstract Using a well-defined subpopulation of human cord blood-derived endothelial progenitors known as endothelial colony-forming cells, researchers evaluated essential requirements for further development of this cell therapy targeting the ischemic retina, including dose response, delivery route, and toxicity. [Stem Cells Transl Med] Full Article The authors reduced the consumption of stem cell factor (SCF) by sustained release but still supported cells proliferation and maintained the multipotency of hematopoietic stem cells (HSCs). SCF remained the native bioactivity, and the proliferation of HSCs within the SCF-loaded hyaluronic acid/gelatin double network hydrogel was not affected, although the consumption of SCF was only a quarter in comparison with the conventional culture. [Cell Prolif] Abstract Microvesicles (MVs) were isolated and injected intravenously into rats immediately after ischemia of the left kidney, and Erk1/2 activator HGF or inhibitor U0126 was administrated, respectively. In vitro, NRK-52E cells treated with MVs under hypoxia injury and with HGF or U0126 administration were used, and cell cycle analysis was performed. [Biochem J] Abstract Stem cell therapy is considered a promising approach in the treatment of amyotrophic lateral sclerosis (ALS) and MSCs seem to be the most effective in ALS animal models. Scientists assessed the effect of repeated intracerebroventricular injections of human umbilical cord-MSCs on disease progression in SOD1G93A mice. [Stem Cell Res] Full Article Researchers examined the ability of obestatin to generate insulin-producing cells (IPCs) in comparison to well-known extrinsic factors that are commonly used in IPCs differentiation protocols from MSCs, namely exendin-4 and glucagon-like peptide-1. Their results showed that Wharton’s jelly-MSCs exhibit all the characteristics of MSCs. [Cell Tissue Res] Abstract | |
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REVIEWSCan Youthful Mesenchymal Stem Cells from Wharton’s Jelly Bring a Breath of Fresh Air for COPD? Scientists discuss the main biological properties of Wharton’s jelly-MSCs pertinent to their potential application for the treatment of chronic obstructive pulmonary disease (COPD) in the context of COPD pathomechanisms with emphasis on chronic immune inflammatory processes that play key roles in the development and progression of COPD. [Int J Mol Sci] Full Article The author summarizes the current progress in understanding the advances in unrelated cord blood transplantation (CBT) for thalassemia. Although as yet only in a limited number of patients, the results of unrelated CBT for thalassemia are encouraging. [Int J Mol Sci] Full Article Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSMajor Lupus Stem Cell Study Receives Funding The Lupus Foundation of America announced it will provide $3.8 million in funding over the next five years to support the first-of-its-kind clinical trial in the United States to evaluate adult mesenchymal stem cells as a treatment for lupus. [Lupus Foundation of America] Press Release Revolutionary New Stem Cell Clinical Trials Geared towards Autism and Cerebral Palsy Americord Registry has announced a significant advancement in stem cell research and clinical trials coming out of Duke University. The FDA has announced expanded access to Duke University Medical Center for sibling or autologous cord blood infusions for children with cerebral palsy, hydrocephalus, hypoxic brain injury, stroke, apraxia, autism and other brain injuries. [Americord Registry (PR Newswire Association LLC.)] Press Release | |
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POLICY NEWSStill No Science Advisor at the White House Ten months into his presidency, Donald Trump has yet to name a science advisor. It’s the longest amount of time a modern president has taken to nominate someone to the position since at least 1976, when Congress established the White House’s Office of Science and Technology Policy. [MIT Technology Review] Editorial Director of HHS Scientific Fraud Office Is out after Stormy 2-Year Tenure The controversial director of the office that polices research fraud in U.S.-funded biomedical labs is temporarily moving to another agency. Kathy Partin has been removed after nearly two years as director of the U.S. Office of Research Integrity in Rockville, Maryland, according to Retraction Watch. [ScienceInsider] Editorial Sudden Shift at a Public Health Journal Leaves Scientists Feeling Censored For much of its 22-year existence, few outside the corner of science devoted to toxic chemicals paid much attention to the International Journal of Occupational and Environmental Health. But now, a feud has erupted over the small academic publication, as its editorial board — the scientists who advise the journal’s direction and handle article submissions — has accused the journal’s new owner of suppressing a paper and promoting “corporate interests over independent science in the public interest.” [Pro Publica Inc.] Editorial
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EVENTSNEW Standardization of the Hematopoietic Progenitor Assay Training Course NEW Applications of the Hematopoietic Progenitor Assay Training Course Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Cord Blood Bank Collector (The University of Texas MD Anderson Cancer Center) Postdoctoral Fellow – Acute Myeloid Leukemia (St. Louis Hospital) Staff Scientist – Hematopoiesis (University of Copenhagen) Scientist – Hematopoietic Stem Cells (Karlsruhe Institute of Technology) Faculty Positions – Hematological Malignancies (University of Alabama at Birmingham) Postdoctoral Fellow – Hematology (University of Tennessee Health Science Center) Postdoctoral Fellowship – Development & Epigenetics (Centre National de la Recherche Scientifique) Postdoctoral Fellow – Hematopoietic Stem Cells (Memorial Sloan Kettering Cancer Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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