Dermal Cell News Volume 1.10 | Jul 20 2015

Acute Activation of Oxidative Pentose Phosphate Pathway as First-Line Response to Oxidative Stress in Human Skin Cells
Researchers investigated the short-term metabolic response in human skin fibroblasts and keratinocytes to H₂O₂ and UV exposure. [Mol Cell] Abstract | Graphical Abstract

Transcription Factor CTIP2 Maintains Hair Follicle Stem Cell Pool and Contributes to Altered Expression of LHX2 and NFATC1
Keratinocytes of the bulge stem cells niche of COUP-TF-interacting protein 2 (Ctip2)^ep-/- mice proliferated more and underwent reduced apoptosis than the corresponding cells of wild-type mice. However, premature activation of follicular stem cells in mice lacking CTIP2 leads to the exhaustion of this stem cell compartment in comparison to Ctip2^L2/L2 mice, which retained quiescent follicle stem cells. [J Invest Dermatol] Abstract

7-Hydroxydehydronuciferine Induces Human Melanoma Death via Triggering Autophagy and Apoptosis
Investigators identified 7-hydroxydehydronuciferine isolated from the leaves of Nelumbo nucifera Gaertn cv Rosa-plena to be a bio-active agent that antagonizes melanoma tumor growth in mice xenograft model in vivo. [Exp Dermatol] Abstract

Modulating the Expression of Survivin and Other Basal Epidermal Proteins Protects Human Skin from UVB Damage and Oxidative Stress
The authors investigated the implication of survivin in epidermal renewal and the relationships between survivin expression and UVB-induced DNA damage levels in cultured human keratinocytes and in skin biopsies. [J Cosmet Dermatol] Abstract

SKIN CANCERS & DISORDERS

CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma
The authors showed that CDKN2B is highly upregulated in benign melanocytic nevi, contributes to maintaining nevus melanocytes in a growth-arrested premalignant state, and is commonly lost in melanoma. [Cancer Discov] Abstract

AMPK/HuR-Driven IL-20 Post-Transcriptional Regulation in Psoriatic Skin
Researchers showed that IL-20 was primarily upregulated in psoriatic skin at the post-transcriptional level. The RNA-binding protein HuR relocalized to the cytoplasm of keratinocytes of psoriatic patients, suggesting that it stabilizes numerous transcripts, as observed in the human keratinocyte cell lines used to assess IL-20 mRNA. [J Invest Dermatol] Abstract

miR-137 Inhibits Proliferation of Melanoma Cells by Targeting PAK2
The authors found that overexpression of miR-137 inhibited the proliferation of melanoma cells, which could be phenocopied by knockdown of p21-activated kinase 2 (PAK2) using siRNAs. [Exp Dermatol] Abstract

MicroRNA-375 Suppresses Extracellular Matrix Degradation and Invadopodial Activity in Head and Neck Squamous Cell Carcinoma
Increased miR-375 expression in head and neck squamous cell carcinoma cells suppressed extracellular matrix degradation and reduced the number of mature invadopodia. Higher miR-375 expression did not reduce cellular levels of selected invadopodia-associated proteins, nor was tyrosine phosphorylation of cortactin altered. [Arch Pathol Lab Med] Abstract | Full Article

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apceth and University of Cologne to Join Forces on Combination Cellular Immunotherapies for Cancer
apceth announced a broad partnership with the Center for Molecular Medicine Cologne, University of Cologne, to combine technologies and expertise, on the development of immunotherapies for solid tumors and hematological malignancies. [apceth GmbH & Co. KG] Press Release

Galderma Receives FDA Approval for New Antibiotic-Free Treatment Option for Acne Patients
Galderma Laboratories, L.P. announced that the U.S. Food and Drug Administration (FDA) approved antibiotic-free Epiduo^® Forte (adapalene and benzoyl peroxide) Gel, 0.3%/2.5%, for the once-daily, topical treatment of acne vulgaris [Galderma Laboratories, L.P] Press Release

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Research Fellow – Tissue Engineering & Regenerative Medicine (National Cancer Center Singapore)

PhD Position – Biomedical Research (Macquarie University)

Senior Scientist – Therapy for Severe, Genetic Skin Diseases (Free University of Berlin)

Assistant/Associate Professor – Melanoma Research (University of Pittsburgh Cancer Institute)

Scientific Writer – Regenerative Medicine (University of Washington)

Assistant/Associate Professor – Dermatology Research (Boston University)

Postdoctoral Fellow – Computational Biology and Bioinformatics in Melanoma (Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellow – Stem Cell Niche Function (Icahn School of Medicine at Mount Sinai)

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