Dermal Cell News Volume 1.14 | Aug 24 2015

    0
    40

    Dermal Cell News 1.14 August 24, 2015

    Dermal Cell News

         In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
    Cell Therapy News on Facebook  DCN on Twitter

     
    TOP STORY
    Combined CSL and p53 Downregulation Promotes Cancer-Associated Fibroblast Activation
    Investigators report that CSL silencing induced senescence of primary fibroblasts from dermis, oral mucosa, breast and lung. CSL functioned in these cells as a direct repressor of multiple senescence- and cancer-associated fibroblasts-effector genes. [Nat Cell Biol] Abstract
    Only One of These Antibodies Will Work for Your Cell Analysis. We Provide Streamlined Solutions that are Reliable and Save You Time

     
    PUBLICATIONS (Ranked by impact factor of the journal)
    DERMAL STEM CELLS & TISSUE REGENERATION

    Keratinocyte Microvesicles Regulate the Expression of Multiple Genes in Dermal Fibroblasts
    Researchers investigated whether microvesicle-like structures are present in human wounds and whether they affect wound healing-associated gene expression in dermal fibroblasts. [J Invest Dermatol] Abstract

    Fate of Prominin-1 Expressing Dermal Papilla Cells During Homeostasis, Wound Healing and Wnt Activation
    By examining endogenous Prominin-1/CD133 (Prom1) expression and expression of LacZ in the skin of Prom1CreERLacZ mice, investigators confirmed that Prom1 is expressed in the dermal papilla of all developing hair follicles and also by postnatal anagen follicles. [J Invest Dermatol] Abstract | Full Article

    Vitamin D Induces Cyclooxygenase 2 Dependent Prostaglandin E2 Synthesis in HaCaT Keratinocytes
    Treatment of human immortalized HaCaT keratinocytes with calcitriol increased prostaglandin E2 production due to increased mRNA and protein expression of COX-2, but not to increase of COX-1 or release of arachidonic acid. [J Cell Physiol] Abstract

    Antibiotics in Cell Culture: Friend or Foe? Suppression of Keratinocyte Growth and Differentiation in Monolayer Cultures and 3D Skin Models
    The authors investigated the effect of the most commonly used antibiotics; gentamycin and the combination of penicillin and streptomycin on keratinocyte growth and differentiation. [Exp Dermatol] Abstract

    Vitamin D and Calcium Regulation of Epidermal Wound Healing
    Mice lacking the vitamin D receptor when placed on a low calcium diet had delayed wound healing. This was associated with reduced β-catenin transcriptional activity and proliferation in the cells at the leading edge of wound closure. [J Steroid Biochem Mol Biol] Abstract

    miR-526b Targets 3′ UTR of MMP1 mRNA
    Using reporter constructs containing the 3′ untranslated region of matrix metalloproteinases 1 (MMP1) and its mutant form, scientists showed that the region from 377–383 in the 3′ UTR of MMP1 is critical for targeting by miR-526b. In addition, the expression pattern of miR-526b and MMP1 mRNA showed reverse relation between adult dermal and neonatal fibroblasts. [Exp Mol Med] Full Article

    SKIN CANCERS & DISORDERS

    Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice
    The authors found that Clock mutation ameliorated imiquimod (IMQ)-induced dermatitis whereas Period2 mutation exaggerated IMQ-induced dermatitis when compared with wild-type mice associated with decreased or increased IL-23 receptor expression in γ/δ+ T cells, respectively. [J Invest Dermatol] Full Article

    The Transcription Cofactor c-JUN Mediates Phenotype Switching and BRAF Inhibitor Resistance in Melanoma
    Most patients with BRAF-mutant metastatic melanoma display remarkable but incomplete and short-lived responses to inhibitors of the BRAF kinase or the mitogen-activated protein kinase kinase (MEK), collectively BRAF/MEK inhibitors. Researchers found that inherent resistance to these agents in BRAF(V600)-mutant melanoma cell lines was associated with high abundance of c-JUN and characteristics of a mesenchymal-like phenotype. [Sci Signal] Abstract

    Atypical Signaling of Metabotropic Glutamate Receptor 1 in Human Melanoma Cells
    Investigators determined if the activation of a canonical G protein-dependent signal transduction cascade, which is often used as an output of metabotropic glutamate 1 (mGlu1) receptor activity in neuronal cells, correlated with mGlu1 receptor-mediated melanoma cell viability. [Biochem Pharmacol] Abstract | Graphical Abstract

    Compound 13, an α1-Selective Small Molecule Activator of AMPK, Potently Inhibits Melanoma Cell Proliferation
    Scientists studied the potential effect of Compound 13 (C13), a novel α1-selective AMP-activated protein kinase (AMPK) activator, in melanoma cells. C13 potently inhibited proliferation in melanoma cell lines, but not in B10BR melanocytes. [Tumor Biol] Abstract

    Development of Simplified and Defined Cell Culture for hPSCs - Watch Now!

     
    REVIEWS
    Nanomaterials for Wound Healing: Scope and Advancement
    The authors summarize the recent progress in advanced therapy for cutaneous wound healing during last five years using a nanotechnology-based approach. [Nanomedicine] Abstract

    Visit our reviews page to see a complete list of reviews in the dermal cell research field.

     
    SCIENCE NEWS
    Groundbreaking Anti-Aging Discovery at Summer Meeting of the American Academy of Dermatology
    A team of research scientists from the Avon Skincare Institute presented a new breakthrough in anti-aging skincare at this week’s Summer Conference of The American Academy of Dermatology [Press release from Avon Products, Inc. discussing research presented at the Summer Conference of The American Academy of Dermatology, New York] Press Release

    New wallchart from our sponsor:
    Mesenchymal Stem Cells (a Nature Reviews Molecular Cell Biology collaboration).
    Request your free copy.

     
    INDUSTRY NEWS
    OncoSec Announces First Patient Enrolled in Phase II Clinical Trial Evaluating Combination of ImmunoPulseâ„¢ IL-12 and Anti-PD-1 Treatment
    OncoSec Medical Incorporated announced enrollment of the first patient into the Phase II Investigator Sponsored Trial led by the University of California, San Francisco to assess the anti-tumor activity, safety, and tolerability of the combination of OncoSec’s investigational therapy, ImmunoPulseâ„¢ IL-12, and Merck’s approved anti-PD-1 agent, KEYTRUDA®, in patients with unresectable metastatic melanoma. [OncoSec Medical Incorporated] Press Release

    $52 Million NIH Grant Advances Clinical and Translational Research at UC San Diego
    The Clinical and Translational Research Institute at University of California, San Diego has received a five-year Clinical and Translational Science Award for approximately $52 million from the National Center for Advancing Translational Science, part of the National Institutes of Health (NIH). [UC San Diego Health] Abstract

    Janus Biotherapeutics Enters Collaboration with Roche in Autoimmune Diseases
    Janus Biotherapeutics announced that they have entered into a collaboration with Roche for the development of a small molecule toll-like receptor inhibitor with the potential to address several autoimmune diseases. [Janus Biotherapeutics (PR Newswire Association LLC)] Press Release

     
    POLICY NEWS
    National Institutes of Health (United States)

    Food and Drug Administration (United States)

    Center for Biologics Evaluation and Research (United States)

    European Medicines Agency (European Union)

    Medicines and Healthcare Products Regulatory Agency (United Kingdom)

    Therapeutic Goods Administration (Australia)

     
    EVENTS
    NEW War on Cancer 2015
    October 20, 2015
    London, United Kingdom

    NEW Innovation and Biomarkers in Cancer Drug Development (IBCD)
    December 3-4, 2015
    Brussels, Belgium

    Visit our events page to see a complete list of events in the dermal cell community.

     
    JOB OPPORTUNITIES
    NEW Research Associate – Skin Inflammation and Carcinogenesis (Imperial College London)

    NEW Postdoctoral Scientist – Skin Microbiome (National Human Genome Research Institute)

    Associate Professor/Professor – Dermatology (University of Texas MD Anderson Cancer Center)

    Senior Manager Immunology – Immunology (Baxalta Innovations GmbH)

    Assistant Professor – Cell Biology or Molecular and Cellular Mechanisms (Washington University School of Medicine)

    PhD Position – Materials Engineering (IFP Energies Nouvelles)

    Postdoctoral Fellow – Cancer Biology (University of Pennsylvania)

    PhD Position – Biomedical Research (Macquarie University)


    Recruit Top Talent: Reach more than 60,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

     

    Have we missed an important article or publication in Dermal Cell News? Click here to submit!

    Comments or suggestions? Submit your feedback here

    Learn more about Dermal Cell News: Archives | Events | Contact Us