Dermal Cell News Volume 1.15 | Aug 31 2015

IFNλ Stimulates MxA Production in Human Dermal Fibroblasts via a MAPK-Dependent STAT1-Independent Mechanism
Researchers revealed cell type-specific differences in interferon lambda (IFNλ) signaling and function in skin resident cells. In dermal fibroblasts, IFNλ induced the expression of MxA, a potent antiviral factor, but not other IFN signature genes as it does in primary keratinocytes. [J Invest Dermatol] Full Article

TLR3 Drives IRF6-Dependent IL-23p19 Expression and p19/EBI3 Heterodimer Formation in Keratinocytes
Investigators report that interferon regulatory factor 6 (IRF6) regulates a subset of toll-like receptor 3 (TLR3) responses in human keratinocytes, including the production of a novel interleukin (IL)-12 family heterodimer (p19/EBI3). [Immunol Cell Biol] Abstract

Dermal Fibroblast Expression of Stromal Cell-Derived Factor-1 (SDF-1) Promotes Epidermal Keratinocyte Proliferation in Normal and Diseased Skin
Scientists investigated the expression and function of a stromal cell-specific protein, SDF-1, in normal human skin and in the tissues of diseased skin. [Protein Cell] Abstract

SKIN CANCERS & DISORDERS

Oxidative Stress-Induced Overexpression of miR-25: The Mechanism Underlying the Degeneration of Melanocytes in Vitiligo
Scientists found that microRNA (miR)-25 was increased in both serum and lesion samples from vitiligo patients, and its serum level was correlated with the activity of vitiligo. [Cell Death Differ] Abstract

Transcriptional Analysis of Vitiligo Skin Reveals the Alteration of WNT Pathway: A Promising Target for Repigmenting Vitiligo Patients
The authors found a significant increase in CXCL10 in non-depigmented and perilesional vitiligo skin compared to levels in healthy control skin; however, neither CXCL10 nor other immune factors were deregulated in depigmented vitiligo skin. [J Invest Dermatol] Abstract

Progression of Mouse Skin Carcinogenesis Is Associated with the Orchestrated Deregulation of miR-200 Family Members, miR-205 and Their Common Targets
The authors exploited a well-established multistage mouse skin carcinogenesis model in order to identify microRNAs consistently implicated in different stages of skin carcinogenesis. [Mol Carcinog] Abstract

Peroxiredoxin 6 Triggers Melanoma Cell Growth by Increasing Arachidonic Acid Dependent Lipid Signaling
Researchers investigated the functional role of peroxiredoxin 6 (PRDX6) in human melanoma cells. They showed that PRDX6 is strongly expressed in most melanoma cells and its expression levels are maintained in a post-transcriptional manner, particularly by EGFR-dependent signaling. [Biochem J] Abstract

HDAC Inhibition Upregulates PD-1 Ligands in Melanoma and Augments Immunotherapy with PD-1 Blockade
Researchers showed that class I histone deacetylase (HDAC) inhibitors upregulated the expression of PD-L1 and, to a lesser degree, PD-L2 in melanomas. Evaluation of human and murine cell lines and patient tumors treated with a variety of HDAC inhibitors in vitro displayed upregulation of these ligands. [Cancer Immunol Res] Abstract

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Celprogen Introduces FolliStem™, an Ideal Product for Regrowth of Human Hair
Celprogen Inc. announced that they have developed a novel product FolliStem™ for Regrowth of human hair. FolliStem™ is manufactured from Adipose Derived Stem Cells that also contains STEMC8007 the human hair follicle stem cell stimulator. [Celprogen Inc. (BusinessWire)] Press Release

MicuRx Reports Positive Top-Line Results in Phase II Clinical Trial for Novel Antibiotic MRX-I in Complicated Skin and Soft Tissue Infections
MicuRx Pharmaceuticals, Inc. announced positive top-line results from the first Phase II clinical study for its lead drug candidate MRX-I. MRX-I is an oral oxazolidinone antibiotic designed to treat drug-resistant bacteria such as MRSA and VRE, while offering physicians and patients a safer and better tolerated therapeutic option than currently available oxazolidinone agents. [MicuRx Pharmaceuticals, Inc.] Press Release

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NEW Postdoctoral Fellow – HMGA Chromatin Remodeling Proteins in Cancer and Stem Cell Biology (Johns Hopkins University School of Medicine)

Research Associate – Skin Inflammation and Carcinogenesis (Imperial College London)

Postdoctoral Scientist – Skin Microbiome (National Human Genome Research Institute)

Senior Manager Immunology – Immunology (Baxalta Innovations GmbH)

Assistant Professor – Cell Biology or Molecular and Cellular Mechanisms (Washington University School of Medicine)

PhD Position – Materials Engineering (IFP Energies Nouvelles)

Postdoctoral Fellow – Cancer Biology (University of Pennsylvania)

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