Dermal Cell News Volume 1.23 | Nov 9 2015

MITF and C-Jun Antagonism Interconnects Melanoma Dedifferentiation with Pro-Inflammatory Cytokine Responsiveness and Myeloid Cell Recruitment
Investigators used functional genomic approaches and identified a reciprocal antagonism between the melanocyte lineage transcription factor MITF and c-Jun, which interconnects inflammation-induced dedifferentiation with pro-inflammatory cytokine responsiveness of melanoma cells favouring myeloid cell recruitment. [Nat Commun] Full Article

Lactobacillus rhamnosus GG Lysate Increases Re-Epithelialization of Keratinocyte Scratch Assays by Promoting Migration
Scientists determined whether probiotic bacteria or their extracts could be beneficial in cutaneous wound healing. [Sci Rep] Full Article

The Cytolinker Plectin Regulates Nuclear Mechanotransduction in Keratinocytes
Investigators examined how cross-talk between the cytolinker plectin and F-actin controls keratin network organisation and the 3D nuclear morphology of keratinocytes. [J Cell Sci] Abstract

TR3 Is Preferentially Expressed by Bulge Epithelial Stem Cells in Human Hair Follicles
Using a cDNA expression assay, investigators discovered that TR3 is significantly enriched in human telogen bulge compared with anagen bulb. [Lab Invest] Abstract

Mechanical Stretch on Human Skin Equivalents Increases the Epidermal Thickness and Develops the Basement Membrane
The authors analyzed the effect of a stretch on keratinization of the epidermis and on the basement membrane. [PLoS One] Full Article

SKIN CANCERS & DISORDERS

NUP160-SLC43A3 Is a Novel Recurrent Fusion Oncogene in Angiosarcoma
The specific driver mutations in angiosarcoma remain unknown. Scientists investigated this issue by transcriptome sequencing of patient-derived angiosarcoma cells, identifying a novel fusion gene NUP160-SLC43A3 found to be expressed in 9 of 25 human angiosarcoma specimens that were examined. [Cancer Res] Abstract | Press Release

Human Papillomavirus Mediated Inhibition of DNA Damage Sensing and Repair Drives Skin Carcinogenesis
The authors showed that cells expressing E6 fail to sense and mount an effective response to repair UV-induced DNA lesions and demonstrated a physiological relevance of E6-mediated inhibition of DNA damage repair for tumor initiation. [Mol Cancer] Full Article

Melanocytes Are More Responsive to IFN-γ and Produce Higher Amounts of Kynurenine than Melanoma Cells
Researchers measured kynurenine pathway (KP) metabolites in human melanoma lines and skin melanocytes and fibroblasts in response to interferon-γ (IFN-γ). IFN-γ affected KP in skin cells more than in melanoma cells, supporting IFN-γ roles in skin physiology and that of stromal cells in modulating the tumor microenvironment. [Biol Chem] Abstract

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MD Anderson’s Moon Shots Mission Grows to Confront Six More Cancer Types
MD Anderson’s Moon Shots Program, an unprecedented effort and novel organizational model designed to more rapidly convert scientific discoveries into life-saving advances, has expanded its targets, adding several of the most intractable cancers to its campaign. [The University of Texas MD Anderson Cancer Center] Press Release

UTA Leads Technology to Create SMART Bandage Tool to Help Monitor, Heal Wounds
The University of Texas at Arlington is developing a sensing and therapeutic tool that will help doctors and other healthcare workers better monitor and heal patients’ complex wounds more quickly. [University of Texas at Arlington] Press Release

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Research Faculty and Associates – Dermatology (University of Pittsburgh)

Postdoctoral Position – Genetic Skin Diseases (Inserm)

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