Dermal Cell News Volume 2.02 | Jan 18 2016

MALT1 Protease Activity Controls the Expression of Inflammatory Genes in Keratinocytes upon Zymosan Stimulation
The authors report that stimulation with zymosan or S. aureus induced MALT1 protease activity in human primary keratinocytes. [J Invest Dermatol] Abstract | Full Article

Hair Follicle Bulge Stem Cells Appear Dispensable for the Acute Phase of Wound Re-Epithelialization
Researchers demonstrated that epidermal injury in murine skin does not induce bulge activation during early epidermal wound repair. [Stem Cells] Abstract

Substance P Enhances EPC Mobilization for Accelerated Wound Healing
Researchers demonstrated that neuropeptide substance P (SP) accelerates the wound healing process, particularly in the skin. Subcutaneous treatment of SP accelerated wound closing, increased the population of α-smooth muscle actin positive myofibroblasts, and increased extracellular matrix deposition at the wound site. [Wound Repair Regen] Abstract

Multipotency of Melanoblasts Isolated from Murine Skin Depends on the Notch Signal Pathway
Investigators showed that melanoblasts (MBs) isolated from mouse skin were multipotent, generating neurons and glial cells together with melanocytes. Using Sox10-IRES-Venus mice and mouse ES cells, they investigated how MBs expressed their multipotency. [Dev Dyn] Abstract

SKIN CANCERS & DISORDERS

ΔNp63 Regulates IL-33 and IL-31 Signaling in Atopic Dermatitis
The authors showed that the p53 family member p63, specifically the ΔNp63, isoform has a key role in driving keratinocyte activation in atopic dermatitis. [Cell Death Differ] Full Article

BRAF Inhibitor Resistance Enhances Vulnerability to Arginine Deprivation in Melanoma
Researchers demonstrated that BRAF inhibitor-resistant melanomas are susceptible to arginine deprivation due to inability to initiate re-expression of argininosuccinate synthetase as well as ineffective autophagy. [Oncotarget] Full Article

Acyl Protein Thioesterase 1 and 2 (APT-1, APT-2) Inhibitors Palmostatin B, ML348 and ML349 Have Different Effects on NRAS Mutant Melanoma Cells
Scientists investigated the expression and function of NRAS depalmitoylating APT-1 and APT-2 in a panel of NRAS mutant melanoma cells. They showed that all melanoma cell lines examined express APT-1 and APT-2.[Oncotarget] Full Article

Silvestrol Induces Early Autophagy and Apoptosis in Human Melanoma Cells
Investigators determined if inhibition of protein synthesis caused by silvestrol triggers autophagy and apoptosis in cultured human cancer cells derived from solid tumors. [BMC Cancer] Full Article

A “Pedi” Cures All: Toenail Trimming and the Treatment of Ulcerative Dermatitis in Mice
Scientists hypothesized that interfering with scratching behavior by trimming the toenails of mice with ulcerative dermatitis (UD), would resolve UD lesions. They evaluated the efficacy of toenail trims with a single application of Vetericyn at the time of treatment versus the previous standard of care, topical Tresaderm applied daily. They found that toenail trims were significantly more effective at resolving lesions. [PLoS One]
Full Article | Press Release

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BBI Receives Frost & Sullivan Award for New Product Innovation for Pressure Ulcer Diagnostics
BBI, LLC announced that it has won the Frost & Sullivan European New Product Innovation Award for Pressure Ulcer Diagnostics for 2015 for the SEM Scanner, BBI’s “revolutionary” hand-held device for detecting early pressure ulcers. [BBI, LLC] Press Release

ReNeuron Wins Major UK Grant to Advance Its Exosome Nanomedicine Platform
ReNeuron Group plc announced that it has been awarded a £2.1 million grant from Innovate UK to further advance its emerging exosome nanomedicine platform. The grant, entitled “Stem cell-derived exosomes for regenerative medicine”, has been awarded under Innovate UK’s Developing Regenerative Medicine & Cell Therapies’ grant scheme. [ReNeuron Group plc] Press Release

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Postdoctoral Fellow – Skin Cancer (German Cancer Research Center)

Postdoctoral Fellow – Stem Cell Biology/Genome Engineering (Amgen)

Professor – Dermato-oncology (Rheinische Friedrich-Wilhelms-University of Bonn)

Postdoctoral Scholarship – Cancer Biology (Lund University)

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Science Content Writer (Howard Hughes Medical Institute)

Postdoctoral Position – Regenerative Medicine (University of Copenhagen)

Postdoctoral Position – Epigenetics of Genome Maintenance (National Cancer Institute)

Research Fellow – Dermatology (Brigham and Women’s Hospital)

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