DERMAL STEM CELLS & TISSUE REGENERATION A Glutathione-Nrf2-Thioredoxin Cross-Talk Ensures Keratinocyte Survival and Efficient Wound Repair Investigators unraveled the function of glutathione in keratinocytes and its cross-talk with other antioxidant defense systems. [PLoS Genet] Full Article Fractionation of a Tumor-Initiating UV Dose Introduces DNA Damage-Retaining Cells in Hairless Mouse Skin and Renders Subsequent TPA-Promoted Tumors Non-Regressing Researchers focus on a possible difference in tumor initiation from a single severe-sunburn dose and from an equal dose fractionated into very low sub-sunburn doses not causing any (growth-promoting) epidermal hyperplasia. [Oncotarget] Full Article Generation of Skin Tissue Using Adipose Tissue-Derived Stem Cells The authors generated skin tissue using adipose tissue-derived mesenchymal stem cells. [Plast Reconstr Surg] Full Article Effects of UVB Radiation on the Physicochemical Properties of Fibroblasts and Keratinocytes Scientists determined the influence of short-wave ultraviolet (UVB) radiation on the membrane electrical properties, phospholipid content, and lipid peroxidation levels of fibroblasts and keratinocytes. [J Membr Biol] Abstract Topical Application of Epidermal Growth Factor with No Scaffold Material on the Healing of Human Traumatic Tympanic Membrane Perforations Investigators evaluated the effects of conservative treatment and topical application of epidermal growth factor with no scaffold material on the healing of human traumatic tympanic membrane perforations. [Clin Otolaryngol] Abstract SKIN CANCERS & DISORDERS FRIZZLED7 Is Required for Tumor Inititation and Metastatic Growth of Melanoma Cells Using an experimental metastasis model, scientists discovered that high levels of the WNT receptor, FZD7, correlated with enhanced metastatic potentials of melanoma cell lines. [PLoS One] Full Article A Novel Multi-CDK Inhibitor P1446A-05 Restricts Melanoma Growth and Produces Synergistic Effects in Combination with MAPK Pathway Inhibitors Scientists report that P1446A-05, a novel multi-CDK inhibitor has significant inhibitory activity against cutaneous and uveal melanoma. [Cancer Biol Ther] Abstract MiR-217 Is Down-Regulated in Psoriasis and Promotes Keratinocyte Differentiation via Targeting GRHL2 The authors found the expression of miR-217 was markedly down-regulated in psoriasis keratinocytes of psoriatic patients. [Biochem Biophys Res Commun] Abstract |