Dermal Cell News Volume 2.04 | Feb 1 2016

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    Dermal Cell News 2.04 February 1, 2016

    Dermal Cell News

         In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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    TOP STORY
    Secondary Tumors Arising in Patients Undergoing BRAF Inhibitor Therapy Exhibit Increased BRAF-CRAF Heterodimerization
    Scientists revealed that BRAF-CRAF complex formation is significantly associated with BRAF inhibitor (BRAFi) treatment and may therefore serve as a useful biomarker of BRAFi-induced cutaneous and extracutaneous tumor formation. [Cancer Res] Abstract
    Weekend-Free Culture hPSCs with mTeSRâ„¢1 or TeSRâ„¢-E8â„¢

     
    PUBLICATIONS (Ranked by impact factor of the journal)
    DERMAL STEM CELLS & TISSUE REGENERATION

    A Glutathione-Nrf2-Thioredoxin Cross-Talk Ensures Keratinocyte Survival and Efficient Wound Repair
    Investigators unraveled the function of glutathione in keratinocytes and its cross-talk with other antioxidant defense systems. [PLoS Genet] Full Article

    Fractionation of a Tumor-Initiating UV Dose Introduces DNA Damage-Retaining Cells in Hairless Mouse Skin and Renders Subsequent TPA-Promoted Tumors Non-Regressing
    Researchers focus on a possible difference in tumor initiation from a single severe-sunburn dose and from an equal dose fractionated into very low sub-sunburn doses not causing any (growth-promoting) epidermal hyperplasia. [Oncotarget] Full Article

    Generation of Skin Tissue Using Adipose Tissue-Derived Stem Cells
    The authors generated skin tissue using adipose tissue-derived mesenchymal stem cells. [Plast Reconstr Surg] Full Article

    Effects of UVB Radiation on the Physicochemical Properties of Fibroblasts and Keratinocytes
    Scientists determined the influence of short-wave ultraviolet (UVB) radiation on the membrane electrical properties, phospholipid content, and lipid peroxidation levels of fibroblasts and keratinocytes. [J Membr Biol] Abstract

    Topical Application of Epidermal Growth Factor with No Scaffold Material on the Healing of Human Traumatic Tympanic Membrane Perforations
    Investigators evaluated the effects of conservative treatment and topical application of epidermal growth factor with no scaffold material on the healing of human traumatic tympanic membrane perforations. [Clin Otolaryngol] Abstract

    SKIN CANCERS & DISORDERS

    FRIZZLED7 Is Required for Tumor Inititation and Metastatic Growth of Melanoma Cells
    Using an experimental metastasis model, scientists discovered that high levels of the WNT receptor, FZD7, correlated with enhanced metastatic potentials of melanoma cell lines. [PLoS One] Full Article

    A Novel Multi-CDK Inhibitor P1446A-05 Restricts Melanoma Growth and Produces Synergistic Effects in Combination with MAPK Pathway Inhibitors
    Scientists report that P1446A-05, a novel multi-CDK inhibitor has significant inhibitory activity against cutaneous and uveal melanoma. [Cancer Biol Ther] Abstract

    MiR-217 Is Down-Regulated in Psoriasis and Promotes Keratinocyte Differentiation via Targeting GRHL2
    The authors found the expression of miR-217 was markedly down-regulated in psoriasis keratinocytes of psoriatic patients. [Biochem Biophys Res Commun] Abstract

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    REVIEWS
    MicroRNAs in Psoriasis
    The authors present a comprehensive review of what is known about microRNAs and their role in the pathogenesis of psoriasis. [J Invest Dermatol] Abstract

    Visit our reviews page to see a complete list of reviews in the dermal cell research field.

     
    INDUSTRY NEWS
    Valeant Announces FDA Acceptance of BLA Submission for Brodalumab in Moderate-to-Severe Plaque Psoriasis
    Valeant Pharmaceuticals International, Inc. announced that the U.S. Food and Drug Administration (FDA) has accepted for review the biologics license application submitted by AstraZeneca in partnership with Valeant, for brodalumab injection, a monoclonal antibody that targets the IL-17 receptor, in development for patients with moderate-to-severe plaque psoriasis. [Valeant Pharmaceuticals International, Inc.] Press Release

    Rockland Immunochemicals, Inc. Introduces Melanoma Cell Lines in Collaboration with The Wistar Institute
    Rockland Immunochemicals, Inc. announced the availability of a new collection of human melanoma cell lines that have been developed and characterized over several decades in the laboratory of Meenhard Herlyn, D.V.M., D.Sc., Caspar Wistar Professor in Melanoma Research, Director of the Melanoma Research Center, and professor in the Molecular and Cellular Oncogenesis Program at The Wistar Institute in Philadelphia. [Rockland Immunochemicals, Inc.] Press Release

    DDK 60 Million Awarded for Four Interdisciplinary Research Projects
    The Novo Nordisk Foundation has awarded grants for four interdisciplinary research projects under the Interdisciplinary Synergy Program. Each project receives up to DKK 15 million per year for three years. [Novo Nordisk Foundation] Press Release

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    POLICY NEWS
    National Institutes of Health (United States)

    Food and Drug Administration (United States)

    Center for Biologics Evaluation and Research (United States)

    European Medicines Agency (European Union)

    Medicines and Healthcare Products Regulatory Agency (United Kingdom)

    Therapeutic Goods Administration (Australia)

     
    EVENTS
    NEW ISSCR 2016 Annual Meeting
    June 22-25, 2016
    San Francisco, United States

    Visit our events page to see a complete list of events in the dermal cell community.

     
    JOB OPPORTUNITIES
    NEW Postdoctoral Scholar – Mechanisms of Metastatic Melanoma (Penn State College of Medicine)

    Professor – Dermatology (Eberhard Karls Universität Tübingen)

    Postdoctoral Research Scientist – Skin Wound Healing and Inflammation (Inserm)

    Postdoctoral Fellow – Skin Cancer (German Cancer Research Center)

    Postdoctoral Fellow – Stem Cell Biology/Genome Engineering (Amgen)

    Professor – Dermato-oncology (Rheinische Friedrich-Wilhelms-University of Bonn)

    Postdoctoral Scholarship – Cancer Biology (Lund University)

    Postdoctoral Fellowship – Tumor Immunology and Cancer Metabolism (Yale University)

    Science Content Writer (Howard Hughes Medical Institute)

    Postdoctoral Position – Regenerative Medicine (University of Copenhagen)

    Postdoctoral Position – Epigenetics of Genome Maintenance (National Cancer Institute)

    Research Fellow – Dermatology (Brigham and Women’s Hospital)


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