DERMAL STEM CELLS & TISSUE REGENERATION Strong Components of Epigenetic Memory in Cultured Human Fibroblasts Related to Site of Origin and Donor Age The authors previously identified relatively greater success culturing dura-derived fibroblasts than scalp-derived fibroblasts from postmortem tissue. They hypothesized that these differences in culture success were related to epigenetic differences between the cultured fibroblasts by sampling location, and therefore generated genome-wide DNA methylation and transcriptome data on 11 intrinsically matched pairs of dural and scalp fibroblasts from donors across the lifespan. [PLoS Genet] Full Article | Press Release Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-Wound Bandages Anti-microbial polycationic dendrimers G3KL and G3RL, able to kill multi-drug resistant Pseudomonas aeruginosa, have been previously developed. The combination of these dendrimers with a class of biological bandages made of progenitor skin cells, which secrete growth factors, could positively impact wound-healing processes. [Sci Rep] Full Article | Press Release Glycerolized Reticular Dermis as a New Human Acellular Dermal Matrix: An Exploratory Study Scientists aimed to develop a new type of human acellular dermal matrix for clinical use, composed of glycerolized reticular dermis decellularized through incubation and tilting in Dulbecco’s Modified Eagle’s Medium. [PLoS One] Full Article SKIN CANCERS & DISORDERS DNMT3B Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR Scientists report that DNMT3B plays a pro-tumorigenic role in human melanoma and that DNMT3B loss dramatically suppresses melanoma formation in the Braf/Pten mouse melanoma model. [Cell Rep] Full Article | Graphical Abstract | Press Release Melatonin Protects Skin Keratinocyte from Hydrogen Peroxide-Mediated Cell Death via the SIRT1 Pathway The authors investigated the protection effect of melatonin on H2O2-induced cell damage and the mechanisms of melatonin in human keratinocytes. [Oncotarget] Full Article Ultraviolet Radiation-Induced Tumor Necrosis Factor Alpha, Which Is Linked to the Development of Cutaneous SCC, Modulates Differential Epidermal MicroRNAs Expression To find clues about the mechanisms by which tumor necrosis factor-alpha may promote ultraviolet radiation-induced development of squamous cell carcinoma (SCC), researchers investigated changes in the expression profiling of microRNAs, which affects translation and stability of mRNAs. [Oncotarget] Full Article Transketolase-Like 1 Ectopic Expression Is Associated with DNA Hypomethylation and Induces the Warburg Effect in Melanoma Cells Investigators evaluated the role of transketolase-like 1 as a mediator of disease progression in melanoma associated with a defective methylation phenotype. [BMC Cancer] Full Article Solar Simulated Ultraviolet Radiation Induces Global Histone Hypoacetylation in Human Keratinocytes Investigators report global changes in histone post-translational modifications induced by solar simulated ultraviolet radiation (ssUVR). A decrease in lysine acetylation of histones H3 and H4, particularly at positions of H3 lysine 9, lysine 56, H4 lysine 5, and lysine 16, was found in human keratinocytes exposed to ssUVR. [PLoS One] Full Article |