Dermal Cell News Volume 2.14 | Apr 18 2016

Fibroblast-Derived MMP-14 Regulates Collagen Homeostasis in Adult Skin
To analyze the function of fibroblast-derived MMP-14 in adult skin homeostasis investigators generated mice with inducible deletion of MMP-14 in the dermal fibroblast. [J Invest Dermatol] Abstract

A Novel Plant Sesquiterpene Lactone Derivative DETD-35 Suppresses BRAFV600E Mutant Melanoma Growth and Overcomes Acquired Vemurafenib Resistance in Mice
Investigators created a novel semi-organically modified derivative, DETD-35, from deoxyelephantopin, a plant sesquiterpene lactone demonstrated as an anti-inflammatory and anti-mammary tumor agent. Their results showed that DETD-35 inhibited proliferation of a panel of melanoma cell lines. [Mol Cancer Ther]
Abstract | Full Article

Controlled Water Vapor Transmission Rate Promotes Wound-Healing via Wound Re-Epithelialization and Contraction Enhancement
Researchers prepared serial polyurethane membrane dressings with graded water vapor transmission rates (WVTRs), and the optimal WVTR of the dressing for wound healing was identified by both in vitro and in vivo studies. The dressing with this optimal WTVR was found to be able to promote wound healing in a mouse skin wound model. [Sci Rep] Full Article

Cellularized Bilayer Pullulan-Gelatin Hydrogel for Skin Regeneration
By combining two polymers: pullulan, an inexpensive polysaccharide with antioxidant properties, and gelatin, a derivative of collagen with high water absorbency, investigators created a novel inexpensive hydrogel-named PG-1 for “pullulan-gelatin first generation hydrogel”-suitable for skin substitutes. [Tissue Eng Part A] Abstract

Downregulation of YAP-Dependent Nupr1 Promotes Tumor-Repopulating Cell Growth in Soft Matrices
The authors showed that nuclear protein 1 (Nupr1), a protein independent of Sox2, is downregulated in tumor-repopulating cells of melanoma, ovarian cancer and breast cancer cultured in soft fibrin matrices. [Oncogenesis] Full Article

Gelatin/Carboxymethyl Chitosan Based Scaffolds for Dermal Tissue Engineering Applications
Scientists delineated the preparation, characterization and application of gelatin-carboxymethyl chitosan scaffolds for dermal tissue engineering. [Int J Biol Macromol] Abstract

SKIN CANCERS & DISORDERS

Standard Melanoma-Associated Markers Do Not Identify the MM127 Metastatic Melanoma Cell Line
Common markers used to identify melanoma cell lines include: S100; HMB-45; and Melan-A. Investigators explored the expression of these three markers in four different melanoma cell lines: WM35; WM793; SK-MEL-28; and MM127. [Sci Rep] Full Article

Local Glucocorticoid Activation by 11β-Hydroxysteroid Dehydrogenase 1 in Keratinocytes
To investigate the function of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in keratinocytes during inflammation in vivo, researchers created keratinocyte-specific 11β-HSD1 knockout mice and analyzed the inflammatory response in models of hapten-induced contact irritant dermatitis. [Am J Pathol] Abstract

Cross-Talk between DopaChromeTautomerase and Caveolin-1 Is Melanoma Cell Phenotype Specific and Potentially Involved in Tumor Progression
A structural and functional relationship between dopachrometautomerase and caveolin-1 was presented in two human amelanotic melanoma cell lines, derived from vertical growth phase and metastatic melanomas. [J Biol Chem] Abstract | Full Article

Visit our reviews page to see a complete list of reviews in the dermal cell research field.

UCLA Joins Collaboration to Advance Cancer Immunotherapy Research
UCLA has joined forces with five of the nation’s other leading cancer centers and The Parker Institute for Cancer Immunotherapy to maximize the potential of cancer immunotherapy research. [UCLA] Press Release

From our sponsor: Learn about detecting cancer stem cells with ALDEFLUOR™. Watch the webinar.

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Visit our events page to see a complete list of events in the dermal cell community.

Faculty Position – Tumor Immunology (John Wayne Cancer Institute at Providence Saint John’s Health Center)

Postdoctoral Position – Stem Cell Biology and Tissue Engineering (Northeastern University)

Skincare Applied Research Manager (L’Oreal)

Senior Bioinformatician – Cutaneous Medicine (Guy’s & St. Thomas’ NHS Foundation Trust)

Postdoctoral Research Fellow – Cancer and Inflammatory Diseases of the Skin (Weill Cornell Medical College)

Postdoctoral Positions – Tissue Repair/Inflammation (Institut Pasteur)

Faculty Position – Radiation Biology (Yale University)

Research Technician – Tumor Initiation and Metastasis (Fred Hutchinson Cancer Research Center)

PhD Position – Stem Cells and Developmental Biology (Vienna Biocenter)

Postdoctoral Fellow – Molecular Regulation of Tissue Repair and Fibrosis (US Army Institute of Surgical Research)

Recruit Top Talent: Reach more than 60,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.