Dermal Cell News Volume 2.25 | Jul 11 2016

TOP STORY

Scientists Identify ‘Cell of Origin’ in Skin Cancers

Scientists have identified for the first time the ‘cell of origin’ in basal cell carcinoma and followed the chain of events that lead to the growth of these invasive tumors. [Press release from Cambridge Stem Cell Institute discussing online prepublication in Nature] Press Release | Abstract

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

Comparative Study of Heparin-Poloxamer Hydrogel Modified bFGF and aFGF for in Vivo Wound Healing Efficiency

Investigators developed a thermos-sensitive heparin-poloxamer hydrogel to load and deliver different growth factors (aFGF and bFGF) for wound healing in vivo. [ACS Appl Mater Interfaces] Abstract

Inhibitory Effect of 2-Methyl-Naphtho[1,2,3-De]Quinolin-8-One on Melanosome Transport and Skin Pigmentation

Investigators found that 2-methyl-naphtho[1,2,3-de]quinolin-8-one induced melanosome aggregation around the nucleus in melan-a melanocytes and in melan-a melanocytes/SP-1 keratinocyte co-cultures without inducing toxicity or changing the melanin content. [Sci Rep] Full Article

BMP1-Like Proteinases Are Essential to the Structure and Wound Healing of Skin

Loss of bone morphogenetic protein 1 (BMP1)-like proteinase activity was shown to result in markedly thinned and fragile skin with unusually densely packed collagen fibrils and delayed wound healing. [Matrix Biol] Full Article

iRhom2^Uncv Mutation Blocks Bulge Stem Cells Assuming the Fate of Hair Follicle

Reseachers found iRhom2 mutation decreased hair matrix proliferation, however, iRhom2 ^Uncv/Uncv mice displayed hyperproliferation and hyperkeratosis in the interfollicular epidermis along with hypertrophy in the sebaceous glands. The number of bulge stem cells was not altered and the hair follicle cycle is normal in iRhom2 ^Uncv/Uncv mice. [Arch Dermatol Res] Abstract

SKIN CANCERS & DISORDERS

FOXM1 Regulates Proliferation, Senescence and Oxidative Stress in Keratinocytes and Cancer Cells

Scientists report that in normal keratinocytes, the expression of FOXM1, a member of the Forkhead superfamily of transcription factors, is controlled by p63. [Aging (Albany NY)] Abstract

Loss of Tumorigenic Potential upon Transdifferentiation from Keratinocytic into Melanocytic Lineage

Scientists identified a distinct set of transcription factors, which are sufficient to transform cells of the keratinocytic lineage to melanocyte-like cells [Sci Rep] Full Article

Rendomab B4, a Monoclonal Antibody That Discriminates the Human Endothelin B Receptor of Melanoma Cells and Inhibits Their Migration

Scientists identified a new monoclonal antibody, rendomab-B4, which, in contrast to rendomab-B1, binds endothelin B receptor expressed on UACC-257, WM-266-4 and SLM8 melanoma cells. [MAbs] Abstract

LncRNA UCA1-miR-507-FOXM1 Axis Is Involved in Cell Proliferation, Invasion and G0/G1 Cell Cycle Arrest in Melanoma.

UCA1 expression was discovered to be upregulated in melanoma tissues and cells, while the depletion of UCA1 led to the inhibition of cell proliferation, invasion and cell cycle arrest. [Med Oncol] Abstract

Wnt/β-Catenin Signaling in Melanoma: Preclinical Rationale and Novel Therapeutic Insights

The authors address the multifaceted regulatory mechanisms of WNT signaling in cancer, with a particular focus on current melanoma therapy, which has witnessed dramatic improvement in the last five years. [Cancer Treat Rev] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.

New Data Shows Sandoz Biosimilar Etanercept Candidate has Equivalent Efficacy to Originator Product

Sandoz announced results from the EGALITY trial in which the primary endpoint of achieving equivalence in Psoriasis Area and Severity Index 75 response rates at week 12 was met. [Press release from Sandoz discussing research presented at Psoriasis 2016, the 5th Congress of the Psoriasis International Network, Paris] Press Release

Galderma Announces FDA Approval of Full Prescription-Strength Differin^® Gel for Over-The-Counter Acne Use

Galderma announced that its U.S. affiliate, Galderma Laboratories, L.P. received approval from the U.S. Food and Drug Administration (FDA) for Differin^® Gel (adapalene gel 0.1%) as an over-the-counter treatment for acne. [Galderma (PR Newswire Association LLC.)] Press Release

Emerald Medical Applications’ DermaCompare™ Wins the Publicis Groupe “Publicis90” Initiative Grand Prize at the Inaugral Viva Technology Paris Event

Emerald Medical Applications Corp. engaged in the development and sale of DermaCompare™, its proprietary artificial intelligence technology and application for the early diagnosis of melanoma and other skin cancers, announced that it was awarded first prize over 3,500 other competing tech companies in the Publicis Groupe 90 initiative at the inaugural edition of Viva Technology Paris. [Emerald Medical Applications Corp. (PR Newswire Association LLC.)] Press Release

Major Funders Launch International Repository of Cutting-Edge Cancer Models

U.S. and European funding agencies are launching the Human Cancer Models Initiative, which aims to give the research community tumor cells that behave more like actual human tumors. [ScienceInsider] Editorial

NEW Nordic Life Science Days 2016
September 14-15, 2016
Stockholm, Sweden

Visit our events page to see a complete list of events in the dermal cell community.

NEW Research Associate – Skin Cell Bioengineering (Imperial College London)

NEW PhD Studentship – Epithelial Stem Cell Biology (Curtin University)

NEW PhD Studentship – Quantitative Biology (University of Heidelberg)

NEW Postdoctoral Fellow – Skin Carcinogenesis (Inserm)

NEW PhD studentship – Dermal Cell Research (University of Southampton)

NEW Postdoctoral Fellow – Modulation of Lipid Organization in the Skin Barrier (Leiden University)

Postdoctoral Research Position – Cytokine Research (Temple University Lewis Katz School of Medicine)

Postdoctoral Positions – Cell, Developmental & Cancer Biology (Oregon Health & Science University)

Postdoctoral Fellow – Tissue Regeneration (US Army Institute of Surgical Research)

Research Scientist – Hair Biophysics (L’Oreal)

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