Dermal Cell News Volume 2.39 | Nov 7 2016

TOP STORY

Safety and Wound Outcomes Following Genetically Corrected Autologous Epidermal Grafts in Patients with Recessive Dystrophic Epidermolysis Bullosa

Scientists assembled autologous recessive dystrophic epidermolysis bullosa keratinocytes transduced with a retroviral vector containing full-length human COL7A1 into epidermal sheet grafts and applied these to six wounds on four patients. [JAMA] Abstract | Press Release

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

Hair Follicles’ Transit-Amplifying Cells Govern Concurrent Dermal Adipocyte Production through Sonic Hedgehog

Researchers discovered that hair follicle transit-amplifying cells play an essential role in orchestrating dermal adipogenesis through secreting Sonic Hedgehog. [Genes Dev] Abstract

Epidermal YAP2-5SA-ΔC Drives β-Catenin Activation to Promote Keratinocyte Proliferation in the Mouse Skin In Vivo

Investigators explored the yes-associated protein (YAP) and β-catenin co-localization in the nuclei of keratinocytes in the regenerating epidermis in vivo, and in proliferating HaCaT keratinocytes in vitro. [J Invest Dermatol] Abstract

Hyaluronate—Epidermal Growth Factor Conjugate for Skin Wound Healing and Regeneration

The transdermal delivery of epidermal growth factor (EGF) poses a significant challenge due to its short half-life and lack of efficient formulation. To improve the transdermal delivery efficiency, researchers conjugated EGF to hyaluronate, which was formulated into a patch-type film for skin wound healing. [Biomacromolecules] Abstract | Graphical Abstract

Extracellular HSP60 Triggers Tissue Regeneration and Wound Healing by Regulating Inflammation and Cell Proliferation

Scientists performed a systematic screen to identify genes essential for hair cell regeneration in zebrafish. [NPJ Regen Med] Full Article | Press Release

SKIN CANCERS & DISORDERS

Cytokine Induced Killer Cells Kill Chemo-Surviving Melanoma Cancer Stem Cells

Scientists explored the MHC-unrestricted activity of cytokine-induced killer cells against chemo-surviving melanoma cancer stem cells. [Clin Cancer Res] Abstract

The Plasma Membrane Ca²⁺ Pump PMCA4b Inhibits the Migratory and Metastatic Activity of BRAF Mutant Melanoma Cells

Researchers investigated the role of plasma membrane Ca²⁺ ATPases (PCMAs) in the maintenance of intracellular Ca²⁺ homeostasis in melanoma cells. [Int J Cancer] Abstract

Chronic Activation of the D156A Point Mutant of Channelrhodopsin-2 Signals Apoptotic Cell Death: The Good and the Bad

Researchers studied the safety of prolonged illumination on channelrhodopsin-2(D156A)-expressing human melanoma cells. [Cell Death Dis] Full Article

Mast Cells Limit the Exacerbation of Chronic Allergic Contact Dermatitis in Response to Repeated Allergen Exposure

Investigators developed and used a chronic contact hypersensitivity model in wild-type and mast cell (MC)-deficient mice and assessed skin inflammatory responses to identify and characterize the role of MCs in chronic allergic contact dermatitis. [J Immunol] Full Article

Intercellular Crosstalk in Human Malignant Melanoma

Scientists review possible strategies to modify the intercellular crosstalk in melanoma that can be employed for therapeutic purposes. [Protoplasma] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.

Supportive Data for the Use of Santalis Pharmaceuticals’ East Indian Sandalwood Oil for the Treatment of Psoriasis Is Presented

Data supporting the use of East Indian sandalwood oil for the treatment of psoriasis was presented by Dr. Manju Sharma of the Vancouver Prostate Centre. [Press release from Santalis Pharmaceuticals. Inc. (Business Wire, Inc.) discussing research presented at 7^th Euro-Global Summit on Toxicology and Applied Toxicology, Rome] Press Release

Ascend Biopharmaceuticals Announces Encouraging Phase I/IIa Interim Results of ASN-002 Treatment of Nodular Basal Cell Carcinoma

Ascend Biopharmaceuticals Ltd announced interim results from the first nine patients of its Phase I/IIa clinical trial evaluating the safety and clinical activity of its lead candidate, ASN-002. The study is evaluating three escalating doses in nodular basal cell carcinoma patients, a common type of skin cancer. [Ascend Biopharmaceuticals Ltd (PR Newswire Association LLC)] Press Release

FDA Approves Expanded Use of ENBREL^® to Treat Children with Chronic Moderate-to-Severe Plaque Psoriasis

Amgen announced that the U.S. Food and Drug Administration (FDA) has approved the supplemental Biologics License Application for the expanded use of ENBREL^®, making it the first and only systemic therapy to treat pediatric patients (ages 4-17) with chronic moderate-to-severe plaque psoriasis. [Amgen Inc.] Press Release

Can-Fite Advances Towards a Pivotal Phase III Clinical Trial in Psoriasis with Piclidenoson Following Reaching Agreement with EMA

Can-Fite BioPharma Ltd. announced that it has reached an agreement with the European Medicines Agency (EMA) on the final design of a global pivotal Phase III trial for its lead drug candidate, Piclidenoson, in the treatment of psoriasis. [Can-Fite BioPharma Ltd.] Press Release

Hard Work, Little Reward: Nature Readers Reveal Working Hours and Research Challenges

A poll answered by thousands of Nature readers suggests that nearly two-thirds have considered quitting research, and that almost 40% work more than 60 hours in a week. The fight for funding is the greatest challenge facing early-career scientists, readers said. [Nature News] Editorial

Twitterstorm Shows Why Scientific Evidence Matters

Grammar and Twitter rarely sit happily, so it would be churlish to point out that when the Welsh MP Glyn Davies tweeted at the weekend: “Nothing more irritating than academics ­rubbishing the efforts of those operating at the sharp end, without facing up to the hard decisions”, he was inadvertently complaining that people at the sharp end (himself included presumably) do not confront hard decisions. [Nature News] Editorial

Russian Science at the Crossroads

As the United States goes to the polls after an unprecedentedly vulgar election campaign, its former cold-war rival is exuding strength and confidence. Just last week, Russia cited its proud history of exploration and science in Antarctica when giving the green light to an international agreement to create a vast marine reserve in the Ross Sea. [Nature News] Editorial

NEW 2017 European Cancer Congress
January 27-30, 2017
Amsterdam, Netherlands

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow – Epithelial Tissue Development (University of California – San Diego)

NEW Professor – Dermatology (Medical University of Vienna)

Postdoctoral Associate – Pathology (Stony Brook University)

Postdoctoral Fellow – Regenerative Medicine (The Henry M. Jackson Foundation for the Advancement of Military Medicine)

Postdoctoral Position – 3D Bioprinting (Inserm)

Postdoctoral Position – Immunobiology of Stromal Cells (Institut Pasteur)

Clinical Trials Fellow – Dermatology (Brigham and Women’s Hospital)

Scientific Director – Global Medical Affairs (Celgene Corporation)

Postdoctoral Researcher – Transplantation Immunology (Nuffield Department of Surgical Sciences)

Pluripotent Stem Cell Faculty Postdoctoral Fellowship – Non-Melanoma Skin Cancer (Brigham and Women’s Hospital) Postdoctoral Researcher – Skin Immunology )

Postdoctoral Fellowship – Non-Melanoma Skin Cancer (Brigham and Women’s Hospital)

Postdoctoral Researcher – Skin Immunology (University Hospital Lausanne)

Postdoctoral Scholar – Cancer Biology (The Pennsylvania State University College of Medicine)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Dermal Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.