Dermal Cell News Volume 3.39 | Nov 27 2017

TOP STORY

Interplay between Notch1 and Notch3 Promotes EMT and Tumor Initiation in Squamous Cell Carcinoma

The authors demonstrated that Notch1 activation and epithelial–mesenchymal transition (EMT) are coupled to promote squamous cell carcinoma tumor initiation in concert with transforming growth factor-β present in the tumor microenvironment. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

Molecular Photoprotection of Human Keratinocytes In Vitro by the Naturally Occurring Mycosporine-Like Amino Acid (MAA) Palythine

HaCaT human keratinocytes were used to assess the photoprotective potential of palythine using a number of endpoints including cell viability, DNA damage, gene expression changes and oxidative stress. [Br J Dermatol] Abstract | Full Article

Insights Into Gene Expression Profiles Induced by Socs3 Depletion in Keratinocytes

To investigate the role of Socs3 in keratinocytes, scientists generated and analyzed global RNA-Seq profiles from Socs3 conditional knockout mice of two different ages. [Sci Rep] Full Article

Cd271 Mediates Proliferation and Differentiation of Epidermal Stem Cells to Support Cutaneous Burn Wound Healing

Scientists highlighted the role of Cd271 in epidermal stem cells during the healing of burn wounds. The expression of Cd271 increased together with burn wound healing. [Cell Tissue Res] Abstract

LncRNA RP11-670E13.6 Regulates Cell Cycle Progression in UVB Damaged Human Dermal Fibroblasts

Investigators performed high-throughput RNA sequencing and comprehensive bioinformatics analyses to characterize the transcriptome profiles including long noncoding RNAs (lncRNAs) and mRNAs in UVB-irradiated primary human dermal fibroblasts and to explore the roles of lncRNAs in photoaging [Photochem Photobiol] Abstract

SKIN CANCERS & DISORDERS

Oral Tolerance Modulates the Skin Transcriptome in Mice with Induced Atopic Dermatitis

Compared to the controls, mice that were orally tolerized and epicutaneously sensitized showed an upregulation of genes that regulate inflammation or keratinocyte differentiation. Knocking down two of those genes, SCGB1A1 and TSC22D3, upregulated Th2 inflammatory mediators and downregulated a cornified cell envelope-related gene. [Allergy] Abstract

Chemical Modification for Proteolytic Stabilization of the Selective αvβ3 Integrin RGDechi Peptide: In Vitro and In Vivo Activities on Malignant Melanoma Cells

Researchers report the synthesis and biological characterization of the novel peptide ψRGDechi as the first step towards novel targeted theranostics in melanoma. Selective inhibition of cell adhesion, wound healing and invasion were demonstrated; near-infrared fluorescent ψRGDechi derivative was able to detect αvβ3 integrin in human melanoma xenografts in a selective fashion. [J Med Chem] Abstract

Down-Regulating Myoferlin Inhibits the Vasculogenic Mimicry of Melanoma via Decreasing MMP-2 and Inducing Mesenchymal-to-Epithelial Transition

Down-regulation of myoferlin by siRNA severely impaired the capability of A375 cells to form vasculogenic mimicry structures in vitro. [J Cell Mol Med] Full Article

Combined Inhibition of MEK and Nuclear ERK Translocation Has Synergistic Antitumor Activity in Melanoma Cells

Scientists found that the NTS-derived peptide significantly reduced the viability of not only BRAF, but also several NRAS and NF1 mutant melanomas. [Sci Rep] Full Article

Cytotoxic Effect of the Serotonergic Drug 1-(1-Naphthyl)Piperazine against Melanoma Cells

Researchers studied the effect of 1-(1-Naphthyl)piperazine on human MNT-1 melanoma cells by evaluating its effects on cell viability, ability to form colonies, cell cycle dynamics, reactive oxygen species production and apoptosis. [Toxicol In Vitro] Abstract | Graphical Abstract

Advanced Glycation End Products in the Pathogenesis of Psoriasis

Intensified glycation of proteins in psoriasis skin might have a role in fueling cutaneous inflammation. In addition, advanced glycation end products released from psoriatic skin may increase metabolic and cardiovascular risk in patients with severe disease. [Int J Mol Sci] Full Article

Understanding the Molecular Genetics of Basal Cell Carcinoma

The authors review established knowledge and new hypotheses regarding the molecular genetics of basal cell carcinoma pathogenesis. [Int J Mol Sci] Full Article

Visit our reviews page to see a complete list of reviews in the dermal cell research field.

European Commission Approves TREMFYA^® (Guselkumab) for the Treatment of Moderate to Severe Plaque Psoriasis in the European Union

Janssen-Cilag International NV announced that the European Commission has approved TREMFYA^® for the treatment of adults with moderate to severe plaque psoriasis who are candidates for systemic therapy. Guselkumab is the first biologic that selectively blocks interleukin-23, a key driver of the immune inflammatory response in psoriasis. [Janssen-Cilag International NV (PR Newswire Association LLC.)] Press Release

LLS Funds $46 Million in New Research to Find Cures

The Leukemia & Lymphoma Society^® (LLS) committed an additional $46 million to fund the most innovative science at leading medical institutions around the world, including Memorial Sloan Kettering Cancer Center in New York, Dana-Farber Cancer Institute in Boston, City of Hope in Duarte, California, and the Walter & Eliza Hall Institute of Medical Research in Australia. [The Leukemia & Lymphoma Society^®] Press Release

Gene Therapy Hits a Peculiar Roadblock: A Virus Shortage

Eager to speed development of revolutionary treatments, the Food and Drug Administration recently announced that it would expedite approval of experimental gene therapies. But the regulatory process may not be the biggest obstacle. [The New York Times] Editorial

Nobel Laureates Demand Release of Iranian Scholar Facing Death Sentence

Some 75 Nobel prize winners have called on the Iranian government to release Ahmadreza Djalali, a researcher in disaster medicine who was sentenced to death last month. The letter is the latest and most powerful protest against the ruling by the scientific community so far. [Nature News] Editorial

Still No Science Advisor at the White House

Ten months into his presidency, Donald Trump has yet to name a science advisor. It’s the longest amount of time a modern president has taken to nominate someone to the position since at least 1976, when Congress established the White House’s Office of Science and Technology Policy. [MIT Technology Review] Editorial

NEW World Vaccine Congress Washington 2018
April 3-5, 2018
Washington, D.C., United States

Visit our events page to see a complete list of events in the community.

NEW Assistant Professor – Cancer Biology (Perelman School of Medicine)

NEW Postdoctoral Research Fellow – Cancer Cell Signaling (University of Sussex)

NEW Faculty Positions – Cancer and Stem Cell Biology (Sun Yat-Sen University)

NEW Postdoctoral Fellows – Cancer/Stem Cell Biology (Stanford University)

Postdoctoral Position – Non-Coding RNAs and Skin Wound Healing (Karolinska Institutet)

Postdoctoral Position – Cancer Biology (University of Pennsylvania)

Postdoctoral Fellow – Skin Cancer and Aging (University of Pennsylvania)

Research Scientist – Melanoma (The Francis Crick Institute)

Assistant or Associate Professor – Melanoma (MD Anderson Cancer Center)

PhD Position – Molecular Biology (University of Luxembourg)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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