Dermal Cell News 4.07 March 5, 2018 | |
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TOP STORYERK5 Is Activated by Oncogenic BRAF and Promotes Melanoma Growth Researchers showed that ERK5 is consistently expressed in human melanoma tissues and is active in melanoma cells. Genetic silencing and pharmacological inhibition of ERK5 pathway drastically reduced the growth of melanoma cells and xenografts harboring wild-type or mutated BRAF. [Oncogene] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONThe Inhibitor of Histone Acetyltransferases Nir Regulates Epidermis Development Scientists showed that epidermis-specific ablation of Nir impairs epidermal stratification and barrier function, thereby causing perinatal lethality. Transcriptome analysis revealed that Nir regulates expression of essential factors of epidermal development, such as keratins, integrins, and laminins. [Development] Abstract Nrf3 Promotes UV-induced Keratinocyte Apoptosis through Suppression of Cell Adhesion Researchers demonstrated a novel pro-apoptotic function of nuclear factor erythroid 2-related factor 3 (Nrf3) in mouse and human keratinocytes. In response to UV irradiation, Nrf3-deficient keratinocytes were protected from apoptosis in vitro and in vivo. [Cell Death Differ] Full Article Pirfenidone Reduces Profibrotic Responses in Human Dermal Myofibroblasts, In Vitro Cultured human dermal fibroblasts were stimulated with TGF-β1 to induce differentiation into profibrotic myofibroblast cells. A dose-dependent reduction in cellular proliferation and migration was observed in TGF-β1-stimulated cells when treated with pirfenidone. [Lab Invest] Abstract The potential of baicalin-loaded nanohydrogels in skin wound healing was demonstrated in vivo in mice by complete skin restoration and inhibition of specific inflammatory markers. [Eur J Pharm Biopharm] Abstract | Graphical Abstract Retinoic Acid Enhances Germ Cell Differentiation of Mouse Skin-Derived Stem Cells Investigators have previously shown that primordial germ cell-like cells, and more advanced oocyte-like cells (OLCs), can be formed by differentiating mouse skin-derived stem cells. Here, they determined the effect of retinoic acid treatment, during stem cell differentiation to germ cells, particularly on the initiation of meiosis. [J Ovarian Res] Full Article SKIN CANCERS & DISORDERSTo understand the mechanisms responsible for survival of BRAF inhibitor-resistant melanoma cells in the context of oxidative stress, the authors have established a preclinical murine model that accurately recapitulates in vivo the acquisition of resistance to MAPK inhibitors including several BRAF or MEK inhibitors alone and in combination. [Cell Death Dis] Full Article Scientists demonstrated that clinostat-modelled simulated microgravity reduces BL6-10 melanoma cell proliferation, adhesion and invasiveness in vitro and decreases tumor lung metastasis in vivo. [Sci Rep] Full Article A Commensal Strain of Staphylococcus epidermidis Protects against Skin Neoplasia Investigators report the discovery that strains of Staphylococcus epidermidis produce 6-N-hydroxyaminopurine (6-HAP), a molecule that inhibits DNA polymerase activity. In culture, 6-HAP selectively inhibited proliferation of tumor lines but did not inhibit primary keratinocytes. [Sci Adv] Full Article | Press Release RORα-Expressing T Regulatory Cells Restrain Allergic Skin Inflammation Using two distinct mouse models of atopic dermatitis, researchers showed that expression of retinoid-related orphan receptor α (RORα) in skin-resident T regulatory cells (Tregs) is important for restraining allergic skin inflammation. In both models, targeted deletion of RORα in mouse Tregs led to exaggerated eosinophilia driven by interleukin-5 production by type 2 innate lymphoid cells and T helper 2 cells. [Sci Immunol] Full Article | |
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REVIEWSImmunomodulation as Rescue for Chronic Atonic Skin Wounds Insights into the immunobiology of both acute and chronic wounds are offering new perspectives for treatments aimed at ‘restarting’ the wound-healing process. The authors review the current state of the field and include the concept that, aside from surgery and stem cell therapy, healing may be enhanced by immunomodulating agents. [Trends Immunol] Abstract Visit our reviews page to see a complete list of reviews in the dermal cell research field. | |
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INDUSTRY NEWSIdera Pharmaceuticals, Inc. announced the start of a Phase III global, multi-center, open-label clinical trial to evaluate the efficacy and safety of intratumoral IMO-2125 in combination with ipilimumab (Yervoy®) versus ipilimumab alone in subjects with anti-PD-1 refractory melanoma. [Idera Pharmaceuticals, Inc.] Press Release The National Institute for Health and Care Excellence (NICE) has issued a Final Appraisal Determination that recommends avelumab for treating adults with metastatic merkel cell carcinoma. [Merck & Co., Inc. (Business Wire, Inc.)] Press Release | |
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POLICY NEWSNew NSF Rules on Sexual Harassment Leave Many Questions Unanswered The National Science Foundation (NSF) in Alexandria, Virginia, hopes that its new policy on sexual harassment will spur universities to deal more aggressively with the pervasive problem. But the additional reporting requirements, which will be officially published in the Federal Register, are far from a definitive statement about how NSF plans to deal with this complex and sensitive subject. [ScienceInsider] Editorial EU Research Chief’s Next Act: Changing the Future of Academic Publishing Robert-Jan Smits, one of Europe’s most powerful figures in research, has been appointed as a special envoy on open science at the European Commission, to help push efforts to make all publicly funded research in Europe freely available by 2020. [Science|Business] Editorial Here’s How the Scientists Running for Office Are Doing They’re trained problem-solvers, but they have to learn to move beyond data to run successful campaigns. [The Atlantic] Editorial Canadian Science Wins Billions in New Budget Canadian Prime Minister Justin Trudeau’s administration released its 2018 budget and scientists couldn’t be happier. It includes almost CAD 4 billion (USD 3.1 billion) in new funding for science over the next five years, a significant portion of which will go to the country’s three granting councils. [Nature News] Editorial
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EVENTSNEW Gordon Research Conferences: Tissue Niches and Resident Stem Cells in Adult Epithelia Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Associate – Biomedical Engineering (University of Minnesota) Postdoctoral Research Associate – Wound Repair (Washington State University) Postdoctoral Fellow – Cancer Research (Indiana University School of Medicine) Scientific Editor – Cancer Cell (Elsevier) Postdoctoral Fellow – Molecular Biology (Cold Spring Harbor Laboratory) PhD Position – Melanoma (University of Luxembourg) Director – Melanoma Global Value Evidence Leader (Merck) Postdoctoral Fellow – Microbiology & Immunology (Johns Hopkins University) Pioneer Award Postdoctoral Fellowships – Melanoma (University of Miami) Faculty Positions – Cancer and Stem Cell Biology (Sun Yat-Sen University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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