Dermal Cell News 5.02 January 21, 2019 | |
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TOP STORYControlled expression of a second activating oncogene led to growth arrest in a subset of cells, which was accompanied by cell cycle arrest and senescence in several melanoma cell lines along with apoptosis. [Oncogene] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONHydrogels containing hyaluronan (HA) and collagen or a mixture with HA sulfated derivatives were shown to bind and release bioactive heparin-binding epidermal growth factor (EGF)-like growth factor over at least 72 hours, which induced keratinocyte migration, EGF receptor-signaling and HGF expression in dermal fibroblasts. [Acta Biomater] Abstract | Graphical Abstract Differential Expression of p120-Catenin 1 and 3 Isoforms in Epithelial Tissues The basal layer of the epidermis and hair follicles expressed P120 catenin isoform 1 (p120-1) with reduced p120-3, whereas most other epithelia co-expressed p120-3 and p120-1, including bronchial epithelia and mammary luminal epithelial cells. [Sci Rep] Full Article Engineering the Migration and Attachment Behavior of Primary Dermal Fibroblasts Researchers studied fibroblast behavior on 3 different 2D surfaces, representative of the dermal ECM and the materials used in the development of dermal scaffolds, in addition to commercially available, collagen-based 3D dermal scaffolds. [Biotechnol Bioeng] Abstract Scientists found a marked alteration in the Golgi morphology during replicative senescence. In contrast to its small and compact structure in non-senescent cells, the Golgi apparatus exhibited a large and expanded morphology in senescent fibroblasts. [Exp Dermatol] Abstract SKIN CANCERS & DISORDERSKLF9-Dependent ROS Regulate Melanoma Progression in Stage-Specific Manner Researchers demonstrated that BRAFV600E signaling transcriptionally upregulated KLF9 and that KLF9-dependent reactive oxygen species (ROS) were required for full-scale activation of ERK1/2 and induction of cell proliferation by BRAFV600E [Oncogene] Abstract Scientists reported that low-cytotoxic concentrations of 5-aza-2′-deoxycytidine, a DNA demethylating agent, prevented in vitro 3D invasiveness of metastatic melanoma cells and reduced lung metastasis formation in vivo. [Clin Epigenetics] Full Article Inhibition of Pannexin 1 Reduces the Tumorigenic Properties of Human Melanoma Cells Investigators showed that Pannexin 1 was highly expressed in human melanoma tumors at all stages of disease progression, as well as in patient-derived cells and established melanoma cell lines. [Cancers] Abstract | Full Article AKT/PKB Associates with β-Actin in the Nucleus of Melanoma Cells Scientists characterized the presence of endogenous nuclear AKT in human melanoma cells and addressed the possible role of AKT by exploring its potential association with key interaction nuclear partners. [Biosci Rep] Abstract Luteolin significantly inhibited the migratory, invasive, adhesive, and tube-forming potential of highly metastatic A375 and B16-F10 melanoma cells or human umbilical vein endothelial cells at sub-IC50 concentrations, where no significant cytotoxicity was observed. [Phytother Res] Full Article Targeting mTORC1/2 with OSI-027 Inhibits Proliferation and Migration of Keloid Keratinocytes The authors showed that both mammalian target of rapamycin (mTOR) complex 1 (mTORC1) and mTORC2 were hyper-activated in keloid-derived primary keratinocytes. Further, OSI-027, an mTOR kinase inhibitor, potently inhibited proliferation and migration of keloid keratinocytes. [Exp Dermatol] Abstract In vitro, PF-271 significantly decreased B16F10 melanoma adhesion to and transmigration through human dermal lymphatic endothelial cells compared to tumor necrosis factor-α treated cells. [Biochem Biophys Res Commun] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cancer Stem Cell News. | |
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REVIEWSA Bundle of Mechanisms: Inner-Ear Hair-Cell Mechanotransduction Recent data from mammalian hair cells challenge longstanding hypotheses regarding adaptation mechanisms and hair-bundle coherence. [Trends Neurosci] Abstract Chitosan Based-Asymmetric Membranes for Wound Healing: A Review The authors provide an overview of the different chitosan-based asymmetric membranes developed for wound dressing applications. [Int J Biol Macromol] Abstract | Graphical Abstract Visit our reviews page to see a complete list of reviews in the dermal cell research field. | |
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INDUSTRY NEWSThe Phase Ib/IIa clinical study will be led by NeoImmuneTech and the Immune Oncology Network. The purpose of this study is to evaluate the safety and preliminary anti-tumor activity of Hyleukin-7 in combination with Tecentriq in approximately 80 patients with anti-PD-(L)1 naïve or relapsed/refractory high-risk skin cancers. [NeoImmuneTech, Inc.] Press Release AIVITA Biomedical Receives IND Clearance for Phase IB Melanoma Trial AIVITA Biomedical, Inc. announced the FDA has cleared its Investigational New Drug (IND) application for a Phase IB clinical trial investigating the company’s ROOT OF CANCER technology in patients with metastatic melanoma. [AIVITA Biomedical, Inc.] Press Release | |
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POLICY NEWSGerman Institutions and Wiley Reach Open-Access Publishing Deal After nearly three years of contract negotiations, a consortium of nearly 700 German libraries, research institutes, and universities called Project DEAL has forged an agreement with the scholarly publisher Wiley that moves the publishing industry towards more open access. [The Scientist] Editorial How UK Scientists Are Planning for a Chaotic No-Deal Brexit British scientists are ramping up preparations for a ‘no deal’ Brexit on 29 March – a situation that would instantly affect travel, data collection, clinical trials and crucial laboratory supplies. [Nature News] Editorial
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EVENTSNEW 2019 ASCO Annual Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellowship – Inner Ear Regeneration (Sunnybrook Research Institute) NEW Postdoctoral Fellowship – Melanoma (Columbia University) NEW Professor – Dermatological Oncology (University of Tübingen) NEW Research Associate – Cell Competition (University of Bristol) PhD Student – Cell Biology (Universitatsklinikum Munster) Postdoctoral Associate – Pathology (Stony Brook University) PhD Studentship – Melanoma (University of Otago) Research Fellow – Stem Cell Biology (Brigham & Women’s Hospital) Postdoctoral Position – Pluripotent Stem Cells (I-STEM) Assistant Professor – Cancer Biology (University of Pennsylvania) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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