Dermal Cell News 5.09 March 18, 2019 | |
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TOP STORYResearchers established and characterized six Merkel cell polyomavirus (MCPyV)-positive Merkel cell carcinoma (MCC) cell lines. All cell lines expressed MCC markers keratin-20 and neuron-specific enolase as well as truncated Merkel cell polyomavirus (MCPyV)-encoded large T antigen. [Int J Cancer] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONScientists found that conditioned medium from α3-expressing mouse keratinocytes, but not from α3-null MK cells, induced expression of cyclooxygenase 2 in fibroblasts in a time and dose-dependent manner, and that this induction was mediated by interleukin-1α (IL-1α). [J Invest Dermatol] Abstract Three-dimensional reconstructed human epidermis was treated for two days with increased concentrations of Cl-amidine, a specific peptidylarginine deiminases inhibitor. Cl-amidine treatments inhibited deimination in a dose-dependent manner and were not cytotoxic for keratinocytes. [J Invest Dermatol] Abstract Cytotoxicity Profiling of Deep Eutectic Solvents to Human Skin Cells The authors chose two cell lines to work as a skin model to assess deep eutectic solvents cytotoxicity. The effect of three different hydrogen bond acceptors and three different hydrogen bond donors were evaluated through a common viability assay. [Sci Rep] Full Article In this study, researchers investigated: the expression of epidermal growth factor like-domain 7 (EGFL7) and its miR-126 in patients affected by diffuse cutaneous systemic sclerosis; the ability of transforming growth factor-beta (TGF-β) to modulate EGFL7 expression; the ability of EGFL7 to modulate COL1A1 expression and proliferation/migration; and the functional role of EGFL7 on angiogenesis. [Sci Rep] Abstract SKIN CANCERS & DISORDERSIn mice melanoma cells, which highly expressed an endogenous αvβ3 integrin, fast cellular uptake of dihydrolipoamide dehydrogenase with RGD motifs, which resulted in cell number reduction, apoptosis induction, and a parallel intracellular reactive oxygen species (ROS) production was shown. Similar results were obtained with additional human melanoma cell models. [Oncogene] Abstract Validation of findings in patient samples of skin squamous cell carcinomas (SCCs) showed a strong correlation between the expression of SDF1, PDGFRA, and PDGFRB, which was upregulated, along CXCR4 in tumor cells of advanced SCCs. [Oncogene] Full Article β3-Adrenoceptor as a Potential Immuno-Suppressor Agent in Melanoma A mouse model of melanoma in which syngeneic B16-F10 cells were injected in C57BL-6 mice was used to evaluate the effect of β-adrenoceptor blockade on the number and activity of immune cell sub-populations. Pharmacological and molecular approaches with β-blockers and specific β-adrenoceptor siRNAs targeting β2- or β3-adrenoceptors were used. [Br J Pharmacol] Abstract Liposomal nanoformulations of the copper complex were characterized in terms of thermodynamic behavior, pH-sensitivity and antiproliferative effects against murine melanoma B16F10 cells in vitro. Preclinical studies were performed in a C57BL/6 syngeneic melanoma model. [Nanomedicine (Lond)] Abstract | Graphical Abstract Investigators showed that the E6 oncoprotein of the βHPV type 8, which infected the cutaneous skin and was associated with skin cancer in Epidermodysplasia verruciformis patients and immunosuppressed organ transplant recipients, and bound to the protein tyrosine phosphatase H1 (PTPH1), which resulted in increased protein expression and phosphatase activity of PTPH1. [Cells] Full Article | Graphical Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cancer Stem Cell News. | |
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REVIEWSThe authors focus on novel mechanistic insights into carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) isoforms for natural killer (NK) cell-mediated immune escape mechanisms in melanoma, and their clinical relevance in patients suffering from malignant melanoma. [Cancers] Full Article Skin Tissue Regeneration for Burn Injury Investigators describe the essentials, achievements, and challenges of cell-based therapy in reducing scar formation and improving burn injury treatment. [Stem Cell Res Ther] Full Article Visit our reviews page to see a complete list of reviews in the dermal cell research field. | |
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INDUSTRY NEWSInMed Pharmaceuticals Inc. provided an update on its drug development program for the treatment of Epidermolysis Bullosa. [InMed Pharmaceuticals, Inc.] Press Release Calgary Firefighters Renew $1M Funding of Skin Regeneration Research at UCalgary Five years ago, the Calgary Firefighters Burn Treatment Society (CFBTS) donated $1 million to create the CFBTS Chair in Skin Regeneration and Wound Healing. Dr. Jeff Biernaskie, PhD was named the inaugural chair. Fast forward to 2019, and the society is pledging another $1 million in continued support of Biernaskie’s groundbreaking research into how dermal stem cells work. [University of Calgary] Press Release | |
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POLICY NEWSSurvey Highlights “Shocking” Gender Bias Among PI Pay in UK Organizers of a survey of early-career scientists in the UK say they are shocked by the picture it paints of gender bias in British science. Women principal investigators (PIs) who have started their own lab in recent years are paid thousands of pounds a year less than men at the same stage of their career, the results show. [The Scientist] Editorial Norway Joins List of Countries Canceling Elsevier Contracts Norway has become the latest country to cancel its contracts with Elsevier following a dispute over access to research papers. In a statement published March 12, the Norwegian Directorate for ICT and Joint Services in Higher Education and Research, which represents a consortium of research institutions in the country, rejected Elsevier’s offer to lower some of its costs for Norwegian institutions because it didn’t go far enough to promote free access to published research. [The Scientist] Editorial
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EVENTSNEW Advanced Cell Therapies and Tissue Engineering Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Researcher – Skin Biology (University of Wisconsin-Madison) NEW Director – Arthritis and Musculoskeletal and Skin Diseases (National Institutes of Health) Postdoctoral Researcher – Wound Healing (Karolinska Institutet) Postdoctoral Scientist – Molecular Oncology (University of Manchester) Research Assistant – Burn Research (Sunnybrook Health Sciences Centre) Postdoctoral Positions – Wound Healing (University of California, Davis) PhD Position – Epidermal Tissue Mechanics (Forschungszentrum Jülich) Postdoctoral Researcher – Skin Biology (Skin Science Foundation) PhD Student – Cancer Research (Luxembourg Institute of Health) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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