Dermal Cell News 5.25 July 22, 2019 | |
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TOP STORYRedox Signals at the ER-Mitochondria Interface Control Melanoma Progression Researchers showed that TMX1 and TMX3 oxidoreductases, which promote endoplasmic reticulum-mitochondria communication, were upregulated in melanoma cells and patient samples. [EMBO J] Full Article | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONInvestigators demonstrated that under proinflammatory conditions, primary human keratinocytes activated naive human T cells. [Cell Mol Immunol] Full Article The authors found the direct delivery of HEKa-microvesicles (MVs) expressing miR-21 mimics significantly promoted the healing of skin wounds in diabetic rats. In-depth studies showed that MV miR-21 promoted fibroblast migration, differentiation, and contraction, induced a pro-angiogenic process of endothelial cells and mediated a pro-inflammatory response. [Int J Biochem Cell Biol] Abstract Scientists found that treatment with withanolides alleviated imiquimod-induced epidermal hyperplasia and inflammatory cell infiltration in the effective skin of model mice. [Molecules] Full Article Researchers present a methodology which is defined as iterative xenografting, which originated in the classical model of human skin substitute xenografts onto immunodeficient recipient mice. [Methods Mol Biol] Abstract SKIN CANCERS & DISORDERSCompound 4a potently inhibited cell proliferation and colony formation, causing an increase of the G2/M phase and a reduction of G0/G1 phase of the cell cycle in both cell lines. [J Med Chem] Abstract Extracellular Acidosis Triggers a Senescence‐Like Phenotype in Human Melanoma Cells Investigators showed that low pH induced senescent/quiescent phenotype in melanoma cells after long‐time treatment defined by induction of SA‐β‐galactosidase, upregulation of p21, G1/G0 cell‐cycle arrest and reduction of proliferation. [Pigment Cell Melanoma Res] Abstract CXCL12 Loaded-Dermal Filler Captures CXCR4 Expressing Melanoma Circulating Tumor Cells In vitro, B16-hCXCR4-GFP, human CXCR4 expressing murine melanoma cells efficiently migrated toward CLG. [Cell Death Dis] Full Article C5a Receptors C5aR1 and C5aR2 Mediate Opposing Pathologies in a Mouse Model of Melanoma Scientists demonstrated that B16.F0 melanoma cells expressed mRNA for both component 5a receptor 1 C5aR1 and C5aR2 and signal through ERK and p38 MAPKs in response to C5a. [FASEB J] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cancer Stem Cell News. | |
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REVIEWSThe Pathological Role of Wnt5a in Psoriasis and Psoriatic Arthritis The authors focus on the pathological role of Wnt5a signaling and its interaction with other interlinked pathways in both psoriasis (PsO) and psoriatic arthritis (PsA), and also on the main challenges for future research, particularly with respect to molecules targeting Wnt signaling pathways for the treatment of PsO and PsA. [J Cell Mol Med] Full Article Visit our reviews page to see a complete list of reviews in the dermal cell research field. | |
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INDUSTRY NEWSElios Therapeutics announced positive top-line results from the company’s prospective, randomized, double-blind, placebo-controlled Phase IIb clinical trial evaluating its lead immuno-oncology candidate, the tumor lysate, particle-loaded, dendritic cell (TLPLDC) vaccine, in patients with Stage III and IV resected melanoma. [Elios Therapeutics (PR Newswire Association LLC.)] Press Release IDEAYA Biosciences, Inc. announced initiation of its Phase I/II study evaluating IDE196 in patients with solid tumors harboring GNAQ/11 mutations or PRKC fusions. [IDEAYA Biosciences, Inc.] Press Release | |
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POLICY NEWSFight for Coveted CRISPR Patents Gets Knottier, as MilliporeSigma Makes New Claims After nearly seven years of failing to win fundamental patents on the genome-editing technology CRISPR, a unit of one of the world’s largest life sciences companies has thrown a Hail Mary: Recently, MilliporeSigma petitioned the US Patent and Trademark office to open an interference proceeding between CRISPR-Cas9 patents that it applied for way back in 2012 and patents that the University of California has applied for or been awarded. [STAT News] Editorial The Plan to Mine the World’s Research Papers Carl Malamud is on a crusade to liberate information locked up behind paywalls — and his campaigns have scored many victories. Now, the 60-year-old American technologist is turning his sights on a new objective: freeing paywalled scientific literature. And he thinks he has a legal way to do it. [Nature News] Editorial
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EVENTSNEW Society for Immunotherapy of Cancer (SITC) 2019 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Burns Medicine (Charles University) PhD Position – Extracellular Matrix & Skin Immunology (University of Freiburg) Faculty Position – Melanoma and Skin Immunobiology (Medical College of Wisconsin) Doctoral Candidate – Tattoo Inks (Federal Institute for Risk Assessment) Research Fellowship – Cancer Biology (Ninewells Hospital and Medical School) Postdoctoral Fellowship – Cancer Immunology and Immunotherapy (H. Lee Moffitt Cancer Center) Postdoctoral Fellow – Cancer Drug Response Research (University of Texas at Austin) Research Lab Specialist – Tumor Microenvironment & Cell Behavior (University of Southern California) Postdoctoral Fellow or PhD Student – Cell and Developmental Biology (University of Geneva) Research Fellowship – Melanoma (Dana-Farber Cancer Institute) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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