Dermal Cell News 5.40 December 2, 2019 | |
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TOP STORYPatch Repair of Deep Wounds by Mobilized Fascia Genetic ablation of fascia fibroblasts prevented matrix from homing into wounds and resulted in defective scars, whereas placing an impermeable film beneath the skin-preventing fascia fibroblasts from migrating upwards-led to chronic open wounds. [Nature] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONInvestigators generated mice with conditional deletion of Mcpip1 in the epidermis. Mcpip1 loss in keratinocytes resulted in the upregulated expression of transcripts encoding factors related to inflammation and keratinocyte differentiation, such as IL-36α/γ cytokines, S100a8/a9 antibacterial peptides, and Sprr2d/2h proteins. [J Mol Med] Abstract IL-23 Induces Regulatory T Cell Plasticity with Implications for Inflammatory Skin Diseases In vitro, IL-23 drove the generation of CD4+Foxp3+RORγt+IL-17A+ cells from Foxp3+ regulatory T cells (Treg). The authors data showed that IL-23 drove Treg plasticity by inducing a population of CD4+Foxp3+RORγt+IL-17A+ cells that could play a role in the disease pathogenesis. [Sci Rep] Full Article Scientists investigated the in vitro NGF responsiveness of keratinocytes, fibroblasts and endothelial cells, also in the presence of adverse microenvironmental conditions. [Am J Physiol Cell Physiol] Abstract Human keratinocyte HaCaT cells were infected with HPV16E6, and condyloma acuminate tissues were collected. The expression level of miR-34a-5p and Jagged 1 (JAG1) were detected in condyloma acuminate tissues and human papillomavirus (HPV)-HaCaT cells. [Pathol Oncol Res] Abstract SKIN CANCERS & DISORDERSTLR9 Activation Cooperates with T Cell Checkpoint Blockade to Regress Poorly Immunogenic Melanoma In the non-immunogenic B16-F10 melanoma model, scientists showed that only intra-tumoral, but not systemic toll-like receptor (TLR)9 activation augmented the therapeutic potential of checkpoint blockade. [J Immunother Cancer] Full Article Researchers showed that high-mobility group box 1 (HMGB1) derived from keratinocytes, but not myeloid cells, delayed cutaneous wound healing and drove tumor formation. In wounds of mice lacking HMGB1 selectively in keratinocytes, a marked reduction in neutrophil extracellular trap formation was observed. [Cell Rep] Full Article | Graphical Abstract Aldo-Keto Reductases Protect Metastatic Melanoma from ER Stress-Independent Ferroptosis Ferroptosis induction and execution were evaluated in metastasis-derived wild-type and oncogenic BRAF melanoma cells, and the process responsible for the resistance has been dissected at molecular level. [Cell Death Dis] Full Article Melanoma Mutations Modify Melanocyte Dynamics in Coculture with Keratinocytes or Fibroblasts Using automated-microscopy and machine-learning-assisted morphology analysis of primary human melanocytes in co-culture, researchers performed combinatorial interrogation of melanocyte genotypic variants and functional assessment of lentivirus-introduced mutations. [J Cell Sci] Abstract miR-489-3p/SIX1 Axis Regulates Melanoma Proliferation and Glycolytic Potential The authors showed that miR-489-3p suppressed sine oculis homeobox 1 (SIX1) expression by directly targeting its 3’-untranslated region in melanoma cells. miR-489-3p suppressed melanoma cell proliferation, migration and invasion through inhibition of SIX1. [Mol Ther Oncolytics] Abstract Investigators studied the effects of the melanoma treatment with two organotin(IV) complexes of the meso-tetra(4-sulfonato-phenyl)porphine, namely (Bu2Sn)2TPPS and (Bu3Sn)4TPPS. In particular, they showed that nanomolar concentrations of (Bu2Sn)2TPPS and (Bu3Sn)4TPPS were sufficient to inhibit melanoma cell growth. [Cells] Full Article Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cancer Stem Cell News. | |
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REVIEWSPPAR-γ Signalling as a Key Mediator of Human Hair Follicle Physiology and Pathology Scientists explore the potential role of PPARγ in androgenetic alopecia, hair follicle energy metabolism, and hair follicle aging, and consider clinical perspectives that emanate from the limited data available on this so far. [Exp Dermatol] Abstract Visit our reviews page to see a complete list of reviews in the dermal cell research field. | |
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INDUSTRY NEWSPellePharm, Inc. announced the completion of enrollment for its pivotal Phase III clinical trial of Patidegib Topical Gel 2% vs. vehicle gel in patients with Gorlin Syndrome. [PellePharm, Inc. (BusinessWire, Inc.)] Press Release ASLAN Pharmaceuticals announced positive preliminary data from the lowest dose cohort of its ongoing multiple ascending dose study of ASLAN004 for the treatment of moderate-to-severe atopic dermatitis. [ASLAN Pharmaceuticals] Press Release | |
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POLICY NEWSElsevier Progresses in Open-Access Deal Making The scholarly publisher has announced several new licensing agreements in both Europe and the US, but some major academic groups are still without contracts and access to journals. [The Scientist] Editorial Chinese Ministry Investigates Duplications in Papers by University President The Chinese education ministry is investigating scientific articles authored by high-profile immunologist and university president Cao Xuetao, following suggestions that dozens of papers contain potentially problematic images. Four journals also say they are examining papers from Cao. [Nature News] Editorial
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EVENTSNEW Advances in Liquid Biopsies Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Researcher – Tumor Heterogeneity (Champalimaud Foundation) Principal Scientist – Dupixent/Type 2 Inflammation and Fibrosis (Sanofi) Postdoctoral Training Fellow – Tumor Heterogeneity (Institute of Cancer Research) Pediatric Physician Scientist – Inflammation or Cancer Biology (Yale School of Medicine) Postdoctoral Fellow/Researcher – Cancer Research Using CRISPR Methods (University of Helsinki) Postdoctoral Fellowships – Cutaneous Biology Research (University of Michigan) Postdoctoral Research Scientist – Genetic Hair and Skin Disorders (Columbia University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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