Dermal Cell News 5.42 December 16, 2019 | |
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TOP STORYHair Eruption Initiates and Commensal Skin Microbiota Aggravate Adverse Events of Anti-EGFR Therapy Scientists found that epidermal growth factor receptor (EGFR)/ERK signaling was required in LRIG1-positive stem cells during de novo hair eruption to secure barrier integrity and prevented the invasion of commensal microbiota and inflammatory skin disease. [Sci Transl Med] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DERMAL STEM CELLS & TISSUE REGENERATIONAutomated Collective Motion Analysis Validates Human Keratinocyte Stem Cell Cultures When cultivated under appropriate conditions, human epidermal keratinocyte stem cells gave rise to colonies and exhibited higher locomotive capacity as well as significant proliferative potential. [Sci Rep] Full Article The enhancement of wound healing by acellular fish skin extract was investigated in vitro on HaCat cells. Researchers showed that acellular fish skin had the highest content of poly-unsaturated fatty acid, followed by human cadaver skin. [J Tissue Eng Regen Med] Abstract In vitro assays showed that the insoluble fur keratin-derived powder containing silver nanoparticles dressing did not inhibit fibroblast growth or induce hemolysis. [J Tissue Eng Regen Med] Abstract SKIN CANCERS & DISORDERSParadoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma Researchers showed that Wnt5A, a non-canonical Wnt ligand that drives a metastatic, therapy-resistant phenotype, stabilized the half-life of p53 and used p53 to initiate a slow-cycling state following stress. Inhibiting p53 blocked the slow-cycling phenotype and sensitized melanoma cells to BRAF/MEK inhibition. [Mol Cell] Abstract | Graphical Abstract Investigators showed that a subpopulation of BRAFV600 mutant melanoma cells that tolerated exposure to BRAF and MEK inhibitors underwent a reversible remodeling of mRNA translation that evolved in parallel with drug sensitivity. [Nat Commun] Full Article The authors investigated the metabolic characteristics and vulnerabilities of acquired resistance to vemurafenib in three generated BRAF-mutant human melanoma cell clones, analysing metabolic profiles, gene and protein expression in baseline and nutrient withdrawal conditions. [Br J Cancer] Full Article A MEK six gene signature was quantified using NanoString and correlated with clinical outcomes. Two components of the gene signature were investigated by gene silencing in BRAF/NRAS wild-type melanoma cells. [Br J Cancer] Abstract LINC00459 Sponging miR-218 to Elevate DKK3 Inhibits Proliferation and Invasion in Melanoma Scientists demonstrated decreased LINC00459 in melanoma cell lines and tissues. According to the in vitro and in vivo experiments, up-regulated LINC00459 had inhibitory effect on cell proliferation and invasion. [Sci Rep] Full Article miR-380-3p Regulates Melanogenesis by Targeting SOX6 in Melanocytes from Alpacas (Vicugna pacos) Luciferase activity assays confirmed that SOX6 was targeted by miR-380-3p. miR-380-3p overexpression and knockdown in alpaca melanocytes respectively downregulated and upregulated SOX6 expression at the mRNA and protein levels. [BMC Genomics] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cancer Stem Cell News. | |
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REVIEWSBlood and skin levels of carotenoids increase during supplementation and due to their antioxidant properties and UV-absorbing effects carotenoids are used as photoprotective agents. [Biochim Biophys Acta] Abstract Dendritic Cells: The Driver of Psoriasis As the prominent cellular source of α-interferon, tumor necrosis factor-α, IL-12 and IL-23, dendritic cells play a pivotal role in psoriasis. Thus, targeting pathogenic dendritic cells subsets is a valid strategy for alleviating and preventing psoriasis and other dendritic cells-derived diseases. [J Dermatol] Abstract Visit our reviews page to see a complete list of reviews in the dermal cell research field. | |
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INDUSTRY NEWSRoche announced the Phase III IMspire150 study, in people with previously untreated BRAF V600 mutation-positive advanced melanoma, met its primary endpoint of progression-free survival. [Roche] Press Release OWC Pharmaceutical Research Corp. announced that the United States Patent and Trademark Office issued a Notice of Allowance indicating that OWC Israel’s Patent Application No. 15/629,230 directed to cannabis based extracts and topical formulations for use in skin disorders, is allowed for issuance as a patent. [OWC Pharmaceutical Research Corp. (PR Newswire, Inc.)] Press Release | |
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POLICY NEWSUK Election Dashes Scientists’ Hopes of Staying in the EU The United Kingdom is now firmly on the path towards leaving the European Union, after the Conservative party won a majority of 79 seats in yesterday’s general election – a result that has major implications for science. [Nature News] Editorial United States Drops Charges against Two More Scientists after Iran Prisoner Swap US authorities have dropped charges against two researchers accused of attempting to export chemicals to Iran in violation of trade sanctions. The decision follows a prisoner swap in which the United States freed a third researcher who was charged alongside them – and imprisoned. [Nature News] Editorial
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EVENTSNEW Lorne Cancer Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Coordinator – Dermatology and Venereology (Karolinska Institutet) Postdoctoral Position – RNA Binding Activity of Glycolytic Enzymes in Melanoma (Institut Curie) Postdoctoral Researcher – Tumor Heterogeneity (Champalimaud Foundation) Principal Scientist – Dupixent/Type 2 Inflammation and Fibrosis (Sanofi) Postdoctoral Training Fellow – Tumor Heterogeneity (Institute of Cancer Research) Pediatric Physician Scientist – Inflammation or Cancer Biology (Yale School of Medicine) Postdoctoral Fellow/Researcher – Cancer Research Using CRISPR Methods (University of Helsinki) Postdoctoral Fellowships – Cutaneous Biology Research (University of Michigan) Postdoctoral Research Scientist – Genetic Hair and Skin Disorders (Columbia University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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