Dermal Cell News Volume 6.05 | Feb 10 2020

TOP STORY

ATP-Citrate Lyase Epigenetically Potentiates Oxidative Phosphorylation to Promote Melanoma Growth and Adaptive Resistance to MAPK Inhibition

In vitro and in vivo functional experiments were performed to determine the effect of ATP-citrate lyase (ACLY) on melanoma growth. mRNA expression profile analysis and a panel of biochemical assays were used to investigate the role of ACLY in mitochondrial oxidative phosphorylation. [Clin Cancer Res] Abstract

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DERMAL STEM CELLS & TISSUE REGENERATION

Handheld Instrument for Wound-Conformal Delivery of Skin Precursor Sheets Improves Healing in Full-Thickness Burns

In porcine pre-clinical models of full-thickness burn, scientists delivered mesenchymal stem/stromal cell-containing fibrin sheets directly to the wound bed, improving re-epithelialization, dermal cell repopulation, and neovascularization. [Biofabrication] Abstract

Tryptanthrin Promotes Keratinocyte and Fibroblast Responses In Vitro after Infection with Trichophyton benhamiae DSM6916

Researchers analyzed the bioactivity of tryptanthrin under infectious conditions using an in vitro dermatophytosis model employing fibroblasts and keratinocytes infected with T. benhamiae DSM6916. [Sci Rep] Full Article

3D Printing of Silver-Doped Polycaprolactone-Poly Propylene Succinate Composite Scaffolds for Skin Tissue Engineering

The cell viability and the cytotoxicity of a developed copolymer were evaluated by using human dermal fibroblast cells. The addition of silver nitrate within the polymer matrix resulted in a significant decrease in the adhesion of different types of microorganisms on the scaffold. [Biomed Mater] Abstract

Role of H3K18ac-Regulated Nucleotide Excision Repair-Related Genes in Arsenic-Induced DNA Damage and Repair of HaCaT Cells

The role of acetylated histone H3K18 (H3K18 ac) in arsenic-induced DNA damage, HaCaT cells were exposed to sodium arsenite for 24 hours. It was found that arsenic induced the downregulation of xeroderma pigmentosum A, D, and F expression, as well as histone H3K18 ac expression, and aggravated DNA damage. [Hum Exp Toxicol] Abstract

SKIN CANCERS & DISORDERS

Circulating Tumor Cell Detection and Polyomavirus Status in Merkel Cell Carcinoma

Investigators compared circulating tumors cell (CTC) detection and characterization in blood samples of patients with Merkel cell carcinoma using the CellSearch System and the RosetteSep -DEPArray workflow, an innovative procedure to enrich, detect and isolate single CTCs. [Sci Rep] Full Article

Monomer Gypenoside LI from Gynostemma pentaphyllum Inhibits Cell Proliferation and Upregulates Expression of miR-128-3p in Melanoma Cells

The authors found that gypenoside LI had a potent cytotoxic effect on melanoma cells. Gypenoside LI induced intrinsic apoptosis along with S phase arrest. Furthermore, gypenoside LI inhibited the colony formation ability of melanoma through inhibition of the Wnt/β-catenin signaling pathway. [J Biochem Mol Toxicol] Abstract

Murine Osteoclastogenesis Suppression Using Conditioned Media Produced by Melanoma or Activated and Non-Activated Jurkat-E6 Cells

Scientists evaluated the effect of conditioned medium obtained from the supernatant of activated and non-activated Jukart-E6 cells, as well as from one murine and one human melanoma cell line. [Cell Biol Int] Abstract

UHPLC-Q/Orbitrap/MS/MS Fingerprinting and Antitumoral Effects of Prosopis strombulifera (LAM.) BENTH. Aqueous Extract on Allograft Colorectal and Melanoma Cancer Models

To correlate in vivo results with in vitro cytotoxicity, B16-F0 cells were cultured to determine: cell proliferation and viability by dye exclusion assays, MTT and CFSE dilution. [Heliyon] Abstract

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Do Innate Killing Mechanisms Activated by Inflammasomes Have a Role in Treating Melanoma?

Some of the innate mechanisms that have evolved against infections with microorganisms and viruses are proving to be active against cancer cells but require better understanding of how they are activated and what inhibitory mechanisms may need to be targeted. [Pigment Cell Melanoma Res] Abstract

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RINVOQ^™ (Upadacitinib) Meets Primary and Key Secondary Endpoints in Phase III Study in Psoriatic Arthritis

AbbVie announced positive top-line results from the Phase III SELECT-PsA 1 clinical trial. In this study, both doses of upadacitinib met the primary endpoint of ACR20 response at week 12 versus placebo in adult patients with active psoriatic arthritis. [AbbVie, Inc.] Press Release

UArizona Cancer Center Receives $6.9M Grant to Study Targeted Prevention of Non-Melanoma Skin Cancer

With funding from the National Cancer Institute, a team of researchers at the University of Arizona Cancer Center is seeking effective preventive and therapeutic strategies to reduce the risk of non-melanoma skin cancer, like squamous cell carcinoma of the skin. [University of Arizona] Press Release

Trump’s 2021 Budget Drowns Science Agencies in Red Ink, Again

It’s another sea of red ink for federal research funding programs in President Donald Trump’s latest budget proposal. The 2021 budget request to Congress released February 10^th calls for deep, often double-digit cuts to R&D spending at major science agencies. [ScienceInsider] Editorial

Major Cancer Institute Sued by Its Own Researchers Over ‘Tapering’ Funding

Alleging that a leading cancer funder is slashing their support in an “unethical and reckless” way, six prominent cancer researchers at the University of California, San Diego have filed a lawsuit to compel it to continue its current level of support. [ScienceInsider] Editorial

NEW American Association for Cancer Research (AACR) Annual Meeting 2020
April 24-29, 2020
San Diego, California, United States

Visit our events page to see a complete list of events in the community.

NEW Senior Research Scientist – Sarcoma (Memorial Sloan Kettering Cancer Center)

Postdoctoral Position – Cancer Biology (Kentsis Research Group)

Researcher – Dermatopathology (Weill Cornell Medical College)

Postdoctoral Fellow – Cancer Pathogenesis (University of Cincinnati)

Postdoctoral Position – Tissue Repair and Inflammation (Memorial Sloan Kettering Cancer Center)

Postdoctoral Fellow – Cancer Research (University of California, San Diego)

Postdoctoral Fellowship – DNA Repair in Skin Melanoma Prevention (University of Southern California)

Laboratory Research Scientist – Advanced Sequencing Facility in Melanoma (The Francis Crick Institute)

Postdoctoral Position – Microbiota and Autoimmunity (The University of Arizona)

Chief Position – Allergy, Immunology, Rheumatology and Dermatology (Harvard Medical School)

Senior Associate Researcher – Inflammatory Skin Diseases (Icahn School of Medicine at Mount Sinai)

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